Results 51 to 60 of about 39,038 (256)

Sulfonylurea Inadequacy [PDF]

Diabetes Care, 2002
OBJECTIVE—To evaluate the efficacy of the addition of insulin when maximal sulfonylurea therapy is inadequate in individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS—Glycemic control, hypoglycemia, and body weight were monitored over 6 years in 826 patients with newly diagnosed type 2 diabetes in 8 of 23 U.K.
Alex Wright, A.C. Felix Burden, Richard B. Paisey, Carole A. Cull, Rury R. Holman   +4 more
openaire   +1 more source

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide [PDF]

, 2001
Background: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial KATP channel opening in myocytes. Glimepiride (Glim) is a new sulfonylurea reported to affect
Baxter, G.F., Lawrence, C.L., Maddock, H.L., Mocanu, M.M., Standen, N.B., Yellon, D.M.   +5 more
core  

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Turfgrass species response exposed to increasing rates of glyphosate application [PDF]

, 2009
To investigate the response of nine turfgrass species exposed to increasing rates of glyphosate application, the dry matter production, visual leaf injury symptoms (e.g., chlorosis and necrosis) and the concentrations of shikimate and mineral nutrients ...
Budak, Hikmet, Cakmak, Ismail, Ozturk, Levent, Su, Y. Senem, Çakmak, İsmail, Öztürk, Levent   +5 more
core   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

eLife, 2017
KATP channels are metabolic sensors that couple cell energetics to membrane excitability. In pancreatic β-cells, channels formed by SUR1 and Kir6.2 regulate insulin secretion and are the targets of antidiabetic sulfonylureas.
Gregory M Martin, Craig Yoshioka, Emily A Rex, Jonathan F Fay, Qing Xie, Matthew R Whorton, James Z Chen, Show-Ling Shyng   +7 more
doaj   +1 more source

Reasoned Opinion on the review of the existing maximum residue levels (MRLs) for amidosulfuron according to Article 12 of Regulation (EC) No 396/2005 [PDF]

EFSA Journal, 2014
According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the Maximum Residue Levels (MRLs) currently established at European level for the pesticide active substance amidosulfuron.
European Food Safety Authority
doaj   +1 more source

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group [PDF]

, 2018
Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease.
Avery, C.L., Bis, J.C., Brody, J.A., Broer, L., Busch, E.L., Chen, Y.-DI., Cummings, S.R., Cupples, L.A., de Mutsert, R., Duan, Q., Eicher, J.D., Evans, D.S., Floyd, J.S., Gogarten, S.M., Gudnason, V., Harris, T.B., Heckbert, S.R., Johnson, A.D., Jukema, J.W., Kaplan, R.C., Kerr, K.F., Kors, J.A., Lange, L.A., Launer, L.J., Laurie, C.C., Li, J., Li, X., Li, Y., Li-Gao, R., Lin, H.J., Liu, Y., Mook-Kanamori, D.O., Méndez-Giráldez, R., Napier, M.D., Noordam, R., Psaty, B.M., Reiner, A.P., Rice, K.M., Roach, J., Rosendaal, F.R., Rotter, J.I., Sattar, N., Seyerle, A.A., Sitlani, C.M., Slagboom, P.E., Smith, A.V., Soliman, E.Z., Sotoodehnia, N., Stewart, J.D., Stott, D.J., Stricker, B.H., Stürmer, T., Taylor, K.D., Trompet, S., Uitterlinden, A.G., Whitsel, E.A., Wiggins, K.L., Wilhelmsen, K.C., Wilson, J.G.   +58 more
core   +4 more sources

Emulating Six Cardiovascular Outcome Trials of Antidiabetic Drugs in Individuals with Type 2 Diabetes: Analyses Based on Real‐World Databases from Korea and Taiwan

Clinical Pharmacology &Therapeutics, EarlyView.
With the increasing volume of clinical evidence derived from large‐scale Asian real‐world data (RWD) and the growing interest in its use in regulatory decision‐making, it is important to conduct benchmarking exercises that evaluate whether studies using Asian RWD can generate similar conclusions as randomized controlled trials (RCTs).
Hwa Yeon Ko, Philip C. M. Au, Michael Chun‐Yuan Cheng, Ching‐Lung Cheung, Ahhyung Choi, Miyuki Hsing‐Chun Hsieh, Han Eol Jeong, Edward Chia‐Cheng Lai, Brian Meng‐Hsun Li, Kenneth K. C. Man, Jeremy A. Rassen, Daniel Hsiang‐Te Tsai, Shirley V. Wang, Ian C. K. Wong, Ju‐Young Shin, Sohee Park   +15 more
wiley   +1 more source

Resistência de plantas daninhas aos herbicidas inibidores da ALS na cultura da soja (Glycine max) Weed resistance to ALS - inhibiting herbicides in soybean (Glycine max) crop

Planta Daninha, 2000
As plantas daninhas Bidens pilosa/Bidens subalternans (picão-preto) e Amaranthus quitensis (caruru) são controladas na cultura da soja por diversos herbicidas, sendo os inibidores da acetolactato sintase (ALS) os mais utilizados pelos sojicultores. O uso
P.A. Monqueiro, P.J. Christoffoleti, C.T.S. Dias   +2 more
doaj   +1 more source