Results 51 to 60 of about 26,603 (276)

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

eLife, 2017
KATP channels are metabolic sensors that couple cell energetics to membrane excitability. In pancreatic β-cells, channels formed by SUR1 and Kir6.2 regulate insulin secretion and are the targets of antidiabetic sulfonylureas.
Gregory M Martin, Craig Yoshioka, Emily A Rex, Jonathan F Fay, Qing Xie, Matthew R Whorton, James Z Chen, Show-Ling Shyng   +7 more
doaj   +1 more source

Sulfonylurea drugs increase early mortality in patients with diabetes mellitus after direct angioplasty for acute myocardial infarction [PDF]

, 1999
Objectives. The purpose of this study was to examine the impact of sulfonylurea drug use on outcome in diabetic patients undergoing direct coronary angioplasty for acute myocardial infarction.Background. Sulfonylurea drugs impair ischemic preconditioning.
David R Holmes, Grill, Diane E, Terzic, Andre, Holmes, David R, Hassinger, Nancy L, Brady, Peter A, Peter A Brady, Andre Terzic, Diane E Grill, Nancy L Hassinger, Garratt, Kirk N, Kirk N Garratt   +11 more
core   +1 more source

Urogenital Infection Risk Associated With SGLT2 Inhibitors Versus DPP‐4 Inhibitors in Type 2 Diabetes and Chronic Kidney Disease: A Nationwide Target Trial Emulation

Clinical Pharmacology &Therapeutics, EarlyView.
Although sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are recommended for patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), concerns regarding urogenital infections persist. Therefore, we evaluated the risk of urinary tract infection (UTI) and genital tract infection (GTI) after SGLT2i initiation in this population ...
Young‐Mi Ah, Junsung Nam, Jung Wook Youn, Yun Mi Yu, Soyoung Kang   +4 more
wiley   +1 more source

Resistência de plantas daninhas aos herbicidas inibidores da ALS na cultura da soja (Glycine max) Weed resistance to ALS - inhibiting herbicides in soybean (Glycine max) crop

Planta Daninha, 2000
As plantas daninhas Bidens pilosa/Bidens subalternans (picão-preto) e Amaranthus quitensis (caruru) são controladas na cultura da soja por diversos herbicidas, sendo os inibidores da acetolactato sintase (ALS) os mais utilizados pelos sojicultores. O uso
P.A. Monqueiro, P.J. Christoffoleti, C.T.S. Dias   +2 more
doaj   +1 more source

Long‐term follow‐up of children with in utero exposure to sulfonylurea medications [PDF]

, 2021
Background Offspring born to mothers with gestational diabetes mellitus (GDM) are more likely to have negative neurodevelopmental health outcomes, early obesity, type 2 diabetes, and metabolic syndrome in childhood, adolescence, and adulthood.
Rodenstein, Marissa S, Marissa S. Rodenstein, Rebecca L. Silton, Murias, Michael, Silton, Rebecca, Maegan U. Ramchal, Ramchal, Maegan U, Josefson, Jami L, Bianco, Monica E, Monica E. Bianco, Michael Murias, Jami L. Josefson   +11 more
core   +1 more source

Meta‐analysis of sotagliflozin, a dual sodium‐glucose‐cotransporter 1/2 inhibitor, for heart failure in type 2 diabetes

ESC Heart Failure, Volume 12, Issue 2, Page 968-979, April 2025.
Abstract Sodium‐glucose co‐transporters (SGLTs) mediate sodium and glucose transport across cell membranes. SGLT2 inhibitors have a recognized place within heart failure (HF) guidelines. We evaluated the effect of sotagliflozin on HF and cardiovascular outcomes in participants with type 2 diabetes. Scopus, Medline, Embase and Central were searched from
Maria Anna Bantounou, Panagiotis Sardellis, Josip Plascevic, Ribeya Awaes‐Mahmood, Justyna Kaczmarek, Daniel Black Boada, Rosa Thuemmler, Sam Philip   +7 more
wiley   +1 more source

Influence of auxin and sulfonylurea herbicides on seeded native communities

, 2004
Sulfonylurea herbicides were used extensively for weed control on Conservation Reserve Program (CRP) seedings, constituting over 98% of the residual herbicides applied from 1986-1990 in southeastern Colorado.
Lair, Kenneth, Redente, Edward F.
core   +1 more source

Reasoned opinion on the review of the existing maximum residue levels (MRLs) for flazasulfuron according to Article 12 of Regulation (EC) No 396/2005 [PDF]

EFSA Journal, 2012
According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the Maximum Residue Levels (MRLs) currently established at European level for the pesticide active substance flazasulfuron.
European Food Safety Authority
doaj   +1 more source

GLUT2 and glucokinase expression is coordinately regulated by sulfonylurea

, 1999
In the present study we examined the effect of sulfonylurea on the expression of the glucose transporter GLUT2 and the glucose phosphorylating enzyme Glucokinase (GK) in beta TC6-F7 cells; furthermore, we studied the modifications induced by sulfonylurea
Federici M, Lauro D, Sesti G, Marlier LNJL, Borboni P, Hribal ML, Magnaterra R, Porzio O, Fusco A   +8 more
core   +1 more source