Results 221 to 230 of about 20,376 (259)

Potential Hypoglycemic Sulfonylureas

Journal of Pharmaceutical Sciences, 1964
A series of N ′-alkyl- N - p -phenylbenzenesulfonylureas and N , N ′-bis ( N -alkylcarbamyl) 4,4′-biphenyldisulfonamides has been prepared for pharmacological studies of their hypoglycemic activities.
K A, NIEFORTH, G L, JENKINS, A M, KNEVEL
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[Sulfonylureas].

Acta medica portuguesa, 1990
Oral antidiabetics are an important aspect of treatment in many diabetics and in the last few years with new developments in the knowledge of type II diabetes physiopathology, there has been a lot of interest in their actions mechanisms. Oral therapy is nevertheless a mere complement which needs to be fitted into a wider group of measures: diabetics ...
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Hepatic effect of sulfonylureas

Metabolism, 1970
Abstract The sulfonylureas, tolbutamide, tolazamide and acetohexamide significantly diminish uptake of insulin by the isolated perfused rat liver, whereas the nonhypoglycemic metabolite of tolbutamide, carboxytolbutamide, has no such effect. These results suggest that the sustained action of the sulfonylureas may in part be due to reduced hepatic ...
A, Marshall, R L, Gingerich, P H, Wright
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Rational use of sulfonylureas

Postgraduate Medicine, 1992
The clinical use of sulfonylureas described in this article is both rational and effective for diabetic patients. Sulfonylureas are not used (1) in patients with insulin-dependent (type I) diabetes, because they are completely ineffective or (2) in patients with non-insulin-dependent (type II) diabetes who respond satisfactorily to diet, because they ...
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Clinical pharmacology of sulfonylureas

Metabolism, 1987
Sulfonylureas seem to have similar mechanisms of action, including an acceleration and increase of insulin secretion, an increase of the systemic availability of insulin, and probably indirectly, an increase of insulin action. Sulfonylureas may postpone the development of impaired glucose tolerance (IGT) to manifest non-insulin-dependent diabetes ...
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Hyperlipemia and Sulfonylurea Therapy

JAMA, 1964
To the Editor:— A report by Shipp et al ( JAMA 188: 468 [May 4] 1964), describing severe hyperlipemia in three diabetics treated with sulfonylurea compounds, proposes that "... enough control to prevent ketosis, but not enough to prevent hyperglycemia, may have provided a longterm metabolic balance favoring the development of hyperlipemia." It is ...
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Sulfonylurea Signal Transduction

1991
In the pancreatic beta cells the proximal step in sulfonylurea signal transduction is the binding of these clinically important drugs to high-affinity receptors in the beta cell membrane. Using HIT cells as a model system, we have established an extremely close correlation between the affinity of binding of glyburide and its analog, iodoglyburide, and ...
A E, Boyd, L, Aguilar-Bryan, J, Bryan, D L, Kunze, L, Moss, D A, Nelson, A S, Rajan, H, Raef, H D, Xiang, G C, Yaney   +9 more
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Management of sulfonylurea ingestions

Pediatric Emergency Care, 1999
In the majority of pediatric patients with an unintentional ingestion of a sulfonylurea, observation and, if necessary, intravenous glucose supplementation, are sufficient. However, with cases of persistent hypoglycemia or cases refractory to IV glucose supplementation, attempts to inhibit insulin secretion should be considered.
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[Sulfonylurea].

Nihon rinsho. Japanese journal of clinical medicine, 2015
SU drug promotes insulin secretion by acting on pancreatic β cell. The hypoglycemic effect is the most powerful among oral diabetic drugs with high cost-effectiveness. Particularly for the Japanese with type 2 diabetes caused by a decrease in insulin secretion as a main pathological condition, it was widely used until the present since 1957 and largely
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Sulfonylureas

Reactions Weekly, 1993
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