Results 151 to 160 of about 26,505 (287)

Habitual fasting duration and accelerated multimorbidity in older adults

Journal of Internal Medicine, Volume 300, Issue 5, Page 642-658, November 2026.
Abstract Background Prolonged fasting has been linked to metabolic benefits in younger adults, but its effects on chronic diseases in older populations remain unclear. Objective To examine the association between habitual fasting duration and 15‐year chronic disease accumulation in older adults, overall, within organ systems, and between age groups ...
Luis Kalmbach, David Abbad‐Gomez, Giorgi Beridze, Fernando Rodríguez‐Artalejo, Davide Liborio Vetrano, Amaia Calderón‐Larrañaga, Adrián Carballo‐Casla   +6 more
wiley   +1 more source

Considering Deintensification and Deprescribing with Higher HbA1c Targets in Vulnerable Older Adults with Type 2 Diabetes: A Retrospective Database Study. [PDF]

Diabetes Ther
Koto R, Yoshida S, Nakajima A, Sugimoto K.   +3 more
europepmc   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, Volume 13, Issue 56, 9 October 2026.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Sulfonylurea Bioisosteres of Sulfonic Acid in JFD 00458-Based ST6GAL1 Inhibitors Enhance Membrane Permeability. [PDF]

ChemMedChem
Koraj N, Dangudubiyyam S, Betances-Mora AM, Faganeli E, Harduin-Lepers A, Angulo J, Nguyen TK, Bort-Griñó M, Hurtado-Guerrero R, Anderluh M.   +9 more
europepmc   +1 more source

Pharmacokinetic and Pharmacodynamic Drug‐Drug Interactions Between Cofrogliptin and Metformin in Healthy Subjects: A Single‐Center, Single‐Arm, Phase I Study in China

Clinical Pharmacology in Drug Development, Volume 15, Issue 10, October 2026.
Abstract This single‐center, single‐arm, Phase I study evaluated drug–drug interactions (DDIs) between cofrogliptin and metformin in healthy Chinese subjects. Twenty‐two subjects sequentially received metformin monotherapy (Days 1–4), cofrogliptin monotherapy (Days 6–34), and combination therapy (Days 38–47).
Cheng Cui, Na Liu, Chang Chu, Shu Niu, Yang Huang, Fangqiong Li, Yaming Li, Haiyan Li, Dongyang Liu   +8 more
wiley   +1 more source

Comparative effectiveness of pioglitazone and sitagliptin added to metformin and sulfonylurea in patients with type 2 diabetes: An emulated target trial. [PDF]

Medicine (Baltimore)
Kim TH, Hwang Y, Woo S, Lee K, Son Y, Park S, Kim H, Shin JY, Cho Y, Shin D, Cho D, Lee KJ, Kim CH, Rhee SY, Yon DK.   +14 more
europepmc   +1 more source

From Simplified Pretreatment to Sensitive Analysis: An Immobilization-Free Cathodic Photoelectrochemical Assay for Sulfonylurea Herbicide Residue and Its Accumulation. [PDF]

ACS Omega
Zhan K, Wang Y, Lin J, Chen F, Fan X, Hu P, Wen J, Gong F, Zhang N.   +8 more
europepmc   +1 more source

Hypoglycemic Effect of Astaxanthin Oil–Fish Oil Complex in Mice With Type 2 Diabetes

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
This study demonstrates that an astaxanthin oil–fish oil complex exerts synergistic hypoglycemic and hepatoprotective effects. It enhances glucose metabolism and relieves oxidative stress in insulin‐resistant HepG2 cells. In high‐fat diet mice, the complex reduces hyperglycemia, improves lipid profiles, and attenuates hepatic steatosis and pancreatic ...
Zhichao Lin, Jianlin He, Xiaomin Xi, Yiping Zhang, Qingqing Le, Yaqi Guo, Hua Fang, Wenhui Jin, Hui Chen, Sijin Chen, Weizhu Chen   +10 more
wiley   +1 more source

The association between SGLT2 inhibitors and rheumatoid arthritis risk in type 2 diabetes: findings from large-scale emulated target trials. [PDF]

Front Immunol
Yen FS, Wang SI, Hsu CC, Tsai SHL, Hwu CM, Wei JC.   +5 more
europepmc   +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source