Results 81 to 90 of about 1,948,666 (273)

A personalized approach to the treatment of neonatal diabetes mellitus caused by a KCNJ11 mutation: clinical observations

Сахарный диабет
Neonatal diabetes mellitus (NDM), or diabetes of the newborn, belongs to the group of monogenic forms of the disease and is characterized by marked genetic polymorphism.
A. S. Severina, А. O. Emelyanov, T. L. Kuraeva, E. A. Sechko, A. N. Zvyagintseva, D. V. Ivanova, M. S. Shamhalova, M. V. Shestakova   +7 more
doaj   +1 more source

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

eLife, 2019
ATP-sensitive potassium (KATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic β-cells to maintain glucose homeostasis.
Gregory M Martin, Min Woo Sung, Zhongying Yang, Laura M Innes, Balamurugan Kandasamy, Larry L David, Craig Yoshioka, Show-Ling Shyng   +7 more
doaj   +1 more source

Identifying resistance‐conferring cytochrome P450s in weeds: experimental strategies and practical considerations

Pest Management Science, EarlyView.
Identifying resistance‐conferring cytochrome P450s requires integrating weed characterization, gene discovery and functional validation. No single approach is sufficient to distinguish causal resistance genes from herbicide‐metabolizing enzymes. Abstract Cytochrome P450 monooxygenases (P450s) play a pivotal role in metabolic herbicide resistance, yet ...
Satoshi Iwakami, Takuya Yamaguchi
wiley   +1 more source

Characterizing geographic diversity of acetolactate synthase resistance in US johnsongrass (Sorghum halepense) biotypes

Pest Management Science, EarlyView.
Geographical distribution of screened Sorghum halepense biotypes across the USA illustrating variation in nicosulfuron response driven by associated ALS resistance‐allele frequencies among representative biotypes. Abstract BACKGROUND Acetolactate synthase (ALS)‐inhibiting herbicides are widely used for Sorghum halepense weed control across ...
Connor Purvis, Eric L Patterson, Erin E Burns   +2 more
wiley   +1 more source

Study on the effect of electrochemical treatment of nicosulfuron wastewater

MATEC Web of Conferences, 2018
Nicosulfuron, a kind of sulfonylurea herbicide, because of its high activity and low dosage, has been widely used in corn planting weeding. Electrochemical method was chosen to treat its simulated waste water and the influence factors such as current ...
Zhao Rui, Jiang Wenqiang
doaj   +1 more source

COST-EFFECTIVENESS ANALYSIS OF INSULIN, SULFONYLUREA, AND SULFONYLUREA– METFORMIN IN TYPE 2 DIABETES MELLITUS

, 2017
Objective: This study aims to compare the cost-effectiveness of insulin therapy, sulfonylureas, and combination of sulfonylureas-metformin in patients with type 2 diabetes mellitus in Sitanala Hospital, Tangerang.Methods: This study employed a cross ...
Endang Laelasari, Rani Sauriasari, Agusdini Banun   +2 more
core   +1 more source

Pesticides and Hypospadias in Southern Brazil: An Ecological Study

Environmental Toxicology, EarlyView.
ABSTRACT Rio Grande do Sul ranks among the Brazilian states with the highest pesticide consumption and one of the highest prevalences of hypospadias, a congenital anomaly often associated with prenatal exposure to endocrine‐disrupting chemicals. We assessed the relationship between prenatal pesticide exposure and hypospadias risk through an ecological ...
Ricardo Rohweder, Márcia Barbian, Juliana da Silva, Nadia Spada Fiori, Lavinia Schuler‐Faccini   +4 more
wiley   +1 more source

Conformational Polymorphism in Sulfonylurea Drugs: Electronic Structure Analysis

, 2016
Quantum chemical calculations have been performed using HF, B3LYP, and MP2 methods on the model sulfonylurea PhSO2NHC(O)NHMe to understand the conformational and tautomeric preferences.
Nikunj K. Patel (2268253), Prasad V. Bharatam (662055), Yoganjaneyulu Kasetti (2044738), Sandeep Sundriyal (1884100)   +3 more
core   +2 more sources

Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances)

EFSA Journal, 2020
The Panel received a mandate from the European Commission to assess the genotoxic potential of triazine amine based on available information submitted by the applicants.
EFSA Panel on Plant Protection Products and their Residues (EFSA PPR Panel), Antonio F Hernandez‐Jerez, Paulien Adriaanse, Annette Aldrich, Philippe Berny, Tamara Coja, Sabine Duquesne, Anne Louise Gimsing, Marina Marinovich, Maurice Millet, Olavi Pelkonen, Silvia Pieper, Aaldrik Tiktak, Christopher J Topping, Ioanna Tzoulaki, Anneli Widenfalk, Gerrit Wolterink, Diane Benford, Gabriele Aquilina, Margherita Bignami, Claudia Bolognesi, Riccardo Crebelli, Rainer Guertler, Francesca Marcon, Elsa Nielsen, Josef Rudolf Schlatter, Christiane Vleminckx, Daniela Maurici, Juan Manuel Parra Morte   +28 more
doaj   +1 more source

Sulfonylurea induced beta-cell apoptosis in cultured human islets

, 2005
Loss of beta-cell mass and function raises a concern regarding the application of sulfonylureas for the treatment of type 2 diabetes because previous studies have shown that agents that cause closure of inwardly rectifying K(+) sulfonylurea receptor ...
Carr, Richard D, Donath, Marc Y, Berney, Thierry, Bosco, Domenico, Maedler, Kathrin, Zuellig, Richard A   +5 more
core   +1 more source