Results 131 to 140 of about 3,641,920 (285)

GLP‐1 at the Metabolic–Cognitive Interface: Reward, Affect, and Memory

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
GLP‐1R signaling integrates metabolic state with neural circuits controlling reward, mood, and memory, acting as a metabolic‐cognitive interface. In reward pathways, it suppresses hedonic feeding and drug seeking; in affective circuits, sustained signaling promotes anxiolytic and antidepressant effects; and in the hippocampus, it enhances synaptic ...
Serena X. Gao, Léa Décarie‐Spain, Cindy Gu, Giulia Mazzini, Scott E. Kanoski, Tito Borner   +5 more
wiley   +1 more source

Gliclazide Enhances Exercise Performance and Recovery of Muscle Strength in Healthy Trained Individuals: A Randomized Controlled Trial

European Journal of Sport Science, Volume 26, Issue 4, April 2026.
ABSTRACT To examine the acute effect of gliclazide on exercise performance and recovery of muscle strength in healthy participants. We conducted a randomized, double‐blind, placebo‐controlled crossover clinical trial in 44 strength‐trained men. They were allocated to gliclazide modified release (MR) (90 mg, 8h before exercise sessions) or placebo ...
Jocelito Bijoldo Martins, Thiago Dipp, Beatriz D. Schaan, Alexandre Machado Lehnen   +3 more
wiley   +1 more source

In Silico Analysis of Phytochemicals of Native Pakistani Plants Having Antidiabetic Potential Targeting GLP‐1R and SGLT2 Proteins

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This study examines the potential of phytochemicals from native Pakistani plants to mitigate the effects of diabetes by interacting with GLP‐1R and SGLT2 proteins using bioinformatics methods, thereby highlighting the application of bioinformatics in this context.
Malaika Ajaz, Waleed Rasool, Amna Mahmood, Faiyaz Ahmed, Anjum Khanam, Dua Zahra, Aqsa Jamshaid, Arooj Arshad, Fakhar Islam, Mohd Asif Shah   +9 more
wiley   +1 more source

Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo [PDF]

The aim of the present study was to investigate in vivo toxic effects and to find acute toxic doses (LD 50) of novel N-sulfonyl derivatives of pyrimidine nucleobases uracil and cytosine. Six N-1-sulfonyluracil derivatives (1, 2, 6, 7, 8, and 9) and two N-
Biserka Žinić, Jure Jerčić, Ksenija Vlahović, Marina Pavlak, Marko Radačić, Ranko Stojković   +5 more
core  

Over-expression of a specific soybean GmGSTU4 isoenzyme improves chloroacetanilide herbicide tolerance of transgenic tobacco plants [PDF]

, 2015
Plant glutathione transferases (GSTs) have a major role in herbicide detoxification. Soybean (Glycine max L.) GmGSTs have been well studied for their correlation in herbicides selectivity towards diphenyl ether, chloroacetanilide and sulfonylurea ...
AthanasiosTsaftaris,, Benekos, Kostantinos, Kissoudis, Christos, Labrou, Nikolaos E., Madesis, Panagiotis, Nianiou-Obeidat, Irini, Voulgari, Georgia   +6 more
core  

Prevalence of Therapeutic Inertia in the Management of Overweight and Obesity in Patients With a Diagnosis of Type 2 Diabetes Who Are Followed up by Primary Care Physicians

Obesity Science &Practice, Volume 12, Issue 2, April 2026.
ABSTRACT Introduction Information on therapeutic inertia (TI) in weight loss in people with type 2 diabetes (T2D) is limited. Objective To describe the prevalence of TI in the management of overweight/obesity in people with T2D undergoing primary care program (PCP) follow‐up and weight changes according to the prescribed treatment.
Pablo Aschner, Diana Henao‐Carrillo
wiley   +1 more source

GCMS profiling of bioactive phytocompounds from Curculigo orchiodes Gaertn. root extract and evaluation of antioxidant, and antidiabetic activities: A computational drug development approach.

PLoS ONE
Curculigo orchioides (C. orchioides), a traditionally valued medicinal plant, has been utilized for centuries in the management of various ailments, but its full spectrum of therapeutical potentials remains underexplored.
Imran Mahmud, Md Khalid Saifullah, Md Niaj Morshed, Md Arju Hossain, Naznin Shahria, Apurba Kumar Barman, Famim Ahmed, Md Jakaria Islam, Toufiq Ejaj Khan, Nripendra Nath Biswas   +9 more
doaj   +1 more source

Prevalence and outcomes of DKA in type 1 and type 2 DM patients treated and not treated with SGLT‐2 inhibitors

Diabetic Medicine, Volume 43, Issue 4, April 2026.
Abstract Aim To compare the clinical characteristics, biochemical presentation, and short‐ and long‐term outcomes of DKA in hospitalized adults with T1DM and T2DM, including the impact of SGLT2 inhibitor therapy. Methods A retrospective cohort of 2283 adults (838 with T1DM; 1445 with T2DM) hospitalized with DKA between 2013 and 2023 across Clalit ...
Elena Chertok Shacham, Sireen Sharif, Rageh Tatoor, Snait Ayalon   +3 more
wiley   +1 more source

Glimepiride protects neurons against amyloid-beta-induced synapse damage [PDF]

, 2016
Bate, C, McHale-Owen, H, Nolan, W, Osborne, C, West, E, Williams, A   +5 more
core   +1 more source

Prognostic value of triglyceride‐derived metabolic parameters for micro‐ and macrovascular complications and mortality in individuals with type 2 diabetes: The Rio de Janeiro type 2 diabetes cohort study

Diabetic Medicine, Volume 43, Issue 4, April 2026.
Prognostic value of triglyceride‐derived metabolic parameters for micro‐ and macrovascular complications and mortality in individuals with type 2 diabetes. Abstract Aims Triglyceride‐derived metabolic parameters have been proposed as indirect measures of insulin resistance and also as predictors of worse prognosis, mainly in Asian populations. However,
Claudia R. L. Cardoso, Guilherme P. Castro, Nathalie C. Leite, Gil F. Salles   +3 more
wiley   +1 more source