Results 51 to 60 of about 1,671,881 (203)

Weight change and risk of cardiovascular disease among adults with type 2 diabetes: more than 14 years of follow-up in the Tehran Lipid and Glucose Study

Cardiovascular Diabetology, 2021
Background To examine the impact of weight change on incident cardiovascular disease and coronary heart disease (CVD/CHD) among an Iranian population with type 2 diabetes mellitus (T2DM).
Seyyed Saeed Moazzeni, Reyhane Hizomi Arani, Niloofar Deravi, Mitra Hasheminia, Davood Khalili, Fereidoun Azizi, Farzad Hadaegh   +6 more
doaj   +1 more source

Characterization of sulfonylurea receptors in isolated human pancreatic islets

, 1998
Current information on pancreatic islet sulfonylurea receptors has been obtained with laboratory animal pancreatic beta cells or stable beta-cell lines.
GIANNACCINI, GINO, MARCHETTI, PIERO, MARTINI, CLAUDIA, DEL GUERRA S., LUPI R., NAVALESI R., BETTI, LAURA, TRINCAVELLI, MARIA LETIZIA, LUCACCHINI, ANTONIO   +8 more
core   +1 more source

Clinical Characteristics and Metabolic Predictors of Rapid Responders to Dipeptidyl Peptidase-4 Inhibitor as an Add-on Therapy to Sulfonylurea and Metformin [PDF]

Diabetes & Metabolism Journal, 2015
BackgroundDipeptidyl peptidase-4 (DPP-4) inhibitor add-on therapy is a new option for patients with inadequately controlled type 2 diabetes who are taking combined metformin and sulfonylurea (SU).
Ye An Kim, Won Sang Yoo, Eun Shil Hong, Eu Jeong Ku, Kyeong Seon Park, Soo Lim, Young Min Cho, Kyong Soo Park, Hak Chul Jang, Sung Hee Choi   +9 more
doaj   +1 more source

Sulfonylurea derivatives of tolbutamide analogues: Synthesis and evaluation of antimicrobial and antioxidant activities [PDF]

, 2018
127-135A series of new sulfonylurea derivatives of tolbutamide analogues have been synthesized in a simple and effective way in high yields to explore the possibilities of some altered biological actions such as antibacterial, antifungal and antioxidant ...
Chalapathi, Ponne Venkata, Vijaya, Tartti, Babu, Pulluru Hari, Rasheed, S, Venkateswarlu, Nagam, Ramudu, D B Janaki, Raju, Chamarthi Naga   +6 more
core  

In Silico Study of New Sulfonylurea Analogs as Potential Antidiabetic Agents: ADMET, Molecular Docking and Dynamics, MM-GBSA and DFT Approach

Journal of Chemistry
Type 2 diabetes mellitus (T2DM) remains one of the leading causes of death globally. Current treatments of this disease involve using sulfonylurea, which is associated with cardiovascular risk and insulin resistance, among others.
Vhushavhelo Musinyali, Kabelo P. Mokgopa, Simon S. Mnyakeni-Moleele, Tendamudzimu Tshiwawa, Ndivhuwo R. Tshiluka   +4 more
doaj   +1 more source

Chalcone: A potential scaffold for NLRP3 inflammasome inhibitors

European Journal of Medicinal Chemistry Reports, 2023
Overactivated NLRP3 inflammasome has been shown to associate with an increasing number of disease conditions. Activation of the NLRP3 inflammasome results in caspase-1-catalyzed formation of active pro-inflammatory cytokines (IL-1β and IL-18) resulting ...
Pritam Thapa, Sunil P. Upadhyay, Vikas Singh, Varun C. Boinpelly, Jianping Zhou, David K. Johnson, Prajwal Gurung, Eung Seok Lee, Ram Sharma, Mukut Sharma   +9 more
doaj   +1 more source

Severe hypoglycemia in users of sulfonylurea antidiabetic agents and antihyperlipidemics

, 2016
Drug-drug interactions causing severe hypoglycemia due to antidiabetic drugs is a major clinical and public health problem. We assessed whether sulfonylurea use with a statin or fibrate was associated with severe hypoglycemia. We conducted cohort studies
S Cardillo, Brensinger, Colleen M., Bilker, Warren B., S Hennessy, Gagne, Joshua J., Cardillo, Serena, X Han, Leonard, Charles E., CE Leonard, Han, Xu, JH Flory, JJ Gagne, DA Flockhart, Flockhart, David A., WB Bilker, Hennessy, Sean, CM Brensinger, Flory, James H.   +17 more
core   +1 more source

Characterization of the rat mesangial cell type 2 sulfonylurea receptor [PDF]

, 1999
Background. Sulfonylurea receptors are classified as either high- affinity type 1 (SUR1) or low-affinity type 2 receptors (SUR2), and the gene expression of SURs has recently been demonstrated in kidney. However, functional data regarding a renal SUR are
Garvin, Jeffrey L, Rodríguez-Barbero, Alicia, Riser, Bruce L, Cortes, Pedro, Szamosfalvi, Balázs, Asano, Kenichiro, Yee, Jerry   +6 more
core   +1 more source

Sulfonylurea-insensitive permanent neonatal diabetes caused by a severe gain-of-function Tyr330His substitution in Kir6.2

, 2022
Background/aims: Mutations in KCNJ11, the gene encoding the Kir6.2 subunit of pancreatic and neuronal KATP channels, are associated with a spectrum of neonatal diabetes diseases. Methods: Variant screening was used to identify cause of neonatal diabetes,
Perri, Alessandro, Nichols, Colin G, Mucciolo, Mafalda, Roeglin, Jacob, McClenaghan, Conor, Cianfarani, Stefano, Gao, Jian, Vento, Giovanni, Barbetti, Fabrizio, Schiaffini, Riccardo, De Rose, Domenico Umberto, Rapini, Novella, Tiberi, Eloisa, Deodati, Annalisa, Bizzarri, Carla, Deodati, A, Schiaffini, R, Mucciolo, M, Roeglin, J, Rapini, N, McClenaghan, C, Bizzarri, C, De, Rose DU, Tiberi, E, Gao, J, Jian Gao, Giovanni Vento, Colin G. Nichols, Eloisa Tiberi, Alessandro Perri, Annalisa Deodati, Riccardo Schiaffini, Domenico Umberto De Rose, Carla Bizzarri, Novella Rapini, Mafalda Mucciolo, Jacob Roeglin, Fabrizio Barbetti, Stefano Cianfarani, Conor McClenaghan   +39 more
core   +1 more source

Implication of sulfonylurea derivatives as prospective inhibitors of human carbonic anhydrase II

, 2018
Selective carbonic anhydrase (CA) inhibitors have gained a lot of importance owing to the implication of specific isoforms of CA in certain diseases like glaucoma, leukemia, cystic fibrosis, and epilepsy.
Danish Idrees, Shahzaib Ahamad, Datta, Bhaskar, Hadianawala, Murtuza, Imtaiyaz Hassan, Md, Amarjyoti Das Mahapatra, Sonam Roy, Ahamad, Shahzaib, Khan, Parvez, Idrees, Danish, Mahapatra, Amarjyoti Das, Bhaskar Datta, Parvez Khan, Md. Imtaiyaz Hassan, Roy, Sonam, Murtuza Hadianawala   +15 more
core   +1 more source