Results 91 to 100 of about 1,671,881 (203)

Transformation Kinetics and Mechanism of the Sulfonylurea Herbicides Pyrazosulfuron Ethyl and Halosulfuron Methyl in Aqueous Solutions

, 2016
Pyrazosulfuron ethyl (PE) and halosulfuron methyl (HM) are two new highly active sulfonylurea herbicides that have been widely used for weed control in a variety of vegetables and other crops.
Scott R. Yates (1414342), Wei Zheng (25452), Sharon K. Papiernik (2354329)   +2 more
core   +1 more source

Using the Scaffold of FDA-Approved Drugs with Trypanocidal Activity to Identify New Anti-Trypanosoma cruzi Agents: An In Silico and In Vitro Approach

Molecules
Chagas disease affects millions of people worldwide, including those in Latin America. The only drugs available for its treatment are benznidazole and nifurtimox. However, these drugs present high toxicity and limited efficacy.
Lenci K. Vázquez-Jiménez, Alonzo González-González, Timoteo Delgado-Maldonado, Rogelio Gómez-Escobedo, Guadalupe Avalos-Navarro, Adriana Moreno-Rodríguez, Alma D. Paz-González, Eyra Ortiz-Pérez, Benjamín Nogueda-Torres, Gildardo Rivera   +9 more
doaj   +1 more source

Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition

, 2001
BM567, a sulfonylurea compound - whose crystal structure is here discussed - and terbogrel, are both thromboxane receptor antagonists and thromboxane synthase inhibitors.
Delarge, Jacques, Rolin, Stéphanie, Wouters, Johan; id_orcid, Michaux, Catherine; id_orcid, Masereel, Bernard, Dogné, Jean-Michel, Durant, François   +6 more
core   +1 more source

Synergism of Synthetic Sulfonamides and Natural Antioxidants for the Management of Diabetes Mellitus Associated with Oxidative Stress

Current Issues in Molecular Biology
In the context of expanding research on the development of compounds with multiple therapeutic actions, this study aims to consolidate findings from the last decade on new synthetic sulfonamide therapies for managing type 2 diabetes mellitus (T2DM ...
Ancuța Dinu (Iacob), Luminita-Georgeta Confederat, Ionut Dragostin, Ionela Daniela Morariu, Dana Tutunaru, Oana-Maria Dragostin   +5 more
doaj   +1 more source

Insulin or sulfonylurea treatments of the diabetics differentially affect erythrocyte membrane and serum enzymes and extent of protein glycosylation

, 2001
Erythrocyte membrane protein glycosylation increase by 3.4 fold in diabetes. Insulin or sulfonylurea treatment did not reduce the extent of glycosylation. The serum protein glycosylation was comparable in all the groups including control.
Patel, T. H, Dave, K. R, Katyare, S. S   +2 more
core   +1 more source

Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes : a meta-analysis

, 2012
OBJECTIVE: Oral antidiabetic drugs (including metformin and sulfonylurea) may play a role in the relationship between type 2 diabetes and cancer. To quantify the association between metformin and sulfonylurea and the risk of cancer, we performed a meta-
Zambon A, La Vecchia C, C. Bosetti, Corrao G., A. Catapano, Catapano A, Bosetti C, G. Corrao, Grassi G, A. Zambon, D. Soranna, G. Grassi, Mancia G, C. La Vecchia, Soranna D, Scotti L, G. Mancia, L. Scotti, Bosetti, C., La Vecchia, C., Corrao, G., Mancia, G., Catapano, A., Grassi, G., Soranna, D., Scotti, L., Zambon, A.   +26 more
core   +1 more source

Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.

, 2008
Ring-opened analogues of dihydrobenzopyran potassium channel openers (PCOs) were prepared and evaluated as putative PCOs on rat aorta rings (myorelaxant effect) and rat pancreatic beta-cells (inhibition of insulin secretion).
Lebrun, P., Khelili, Smail, de Tullio, Pascal, Pirotte, Bernard, Mechouch, Nadia, Mechouch, N., Abdelaziz, Samia, Bouhadja, M., Mohamed, Y., Mohamed, Yekhlef, Abdelaziz, S., Bouhadja, Mourad, Lebrun, Philippe, Khelili, S., Florence, Xavier   +14 more
core   +1 more source

Treatment progression in sulfonylurea and dipeptidyl peptidase-4-inhibitor cohorts of type 2 diabetes patients on metformin

, 2016
Xiaomei Peng, Dingfeng Jiang, Dongju Liu, Oralee J Varnado, Jay P Bae Eli Lilly and Company, Global Patient Outcomes and Real World Evidence, Indianapolis, IN, USA Background: Metformin is an oral antidiabetic drug (OAD) widely used as first-line ...
Peng X, Varnado OJ, Bae JP, Jiang D, Liu D   +4 more
core  

Renal functional reserve predicts GFR response to empagliflozin in RENALIS and RACELINES clinical trials. [PDF]

Nephrol Dial Transplant
van Baar MJB, Bjornstad P, Touw DJ, Joles JA, Krebber MM, Cherney DZI, van Raalte DH, Muskiet MHA.   +7 more
europepmc   +1 more source

Lead optimization of AMS-17 identifies AMS-4 as a modulator of inflammasome-driven cocaine-associated neuroinflammation. [PDF]

Biochem Biophys Res Commun
Singh S, Gupta NK, Ahsan AU, Oladapo A, Mata LO, Buch S, Kulkarni A, Periyasamy P.   +7 more
europepmc   +1 more source