Results 121 to 130 of about 1,948,666 (273)

Cardiovascular Outcomes in Semaglutide Versus Tirzepatide Users With Obesity and Atherosclerotic Disease: A Target Trial Emulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Semaglutide, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is approved for cardiovascular risk reduction in individuals with overweight or obesity and cardiovascular disease. Whether tirzepatide, a dual GLP‐1 and glucose‐dependent insulinotropic polypeptide receptor agonist, has similar cardiovascular benefits remains unknown.
Gwen Aubrac, Rafeya V. Raquib, Minh T. Le, Michael Webster‐Clark, Robert W. Platt, Andrew C. Stokes   +5 more
wiley   +1 more source

Semaglutide in type 2 diabetes and chronic kidney disease in Australia: practical clinical considerations from a multidisciplinary panel

Internal Medicine Journal, EarlyView.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) are major causes of morbidity and mortality in people with type 2 diabetes (T2D). Contemporary CKD guidelines increasingly support incorporation of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) as an additional pillar of cardiorenal therapy alongside renin–angiotensin ...
Eugenia Pedagogos, Roger Chen, Adam Nelson, Sunil Badve, Roy Rasalam, Richard MacIsaac   +5 more
wiley   +1 more source

Genetic and Clinical Determinants of Variation in Drug Response in Type 2 Diabetes: Insights From the Scottish and UK Biobank Cohorts. [PDF]

Diabetes Obes Metab
ABSTRACT Objective Treatment response in type 2 diabetes (T2D) varies widely among individuals. This study aimed to quantify the contributions of clinical characteristics and genetic predisposition as measured through partitioned polygenic risk scores (pPRS) to variation in glycemic response to glucose‐lowering therapies.
Garg S, Kitchen R, Gupta R, Donnelly L, Pearson ER.   +4 more
europepmc   +2 more sources

History of gastrointestinal symptoms with other glucose‐lowering agents is associated with gastrointestinal adverse events after imeglimin initiation: A retrospective real‐world study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Imeglimin is an oral antidiabetic agent with a novel mechanism of action. Gastrointestinal (GI) adverse events (AEs) have been reported during imeglimin therapy. However, the factors associated with the occurrence of GI AEs have not been fully elucidated. This study aimed to investigate the incidence of GI AEs and the factors
Kodai Yoshida, Yukiko Onishi, Tetsuya Kubota, Yoko Yoshida, Tazu Tahara, Satoru Takase, Masahiko Iwamoto, Ryusuke Nakada, Hikaru Aita, Masato Kasuga   +9 more
wiley   +1 more source

SEPARATION OF SULFONYLUREA METABOLITES IN WATER BY CAPILLARY ELECTROPHORESIS

, 1995
The potential of capillary electrophoresis (CE) for the separation and detection of the metabolites of nine sulfonylurea herbicides in aqueous solution was evaluated.
VICARI A, BONETTI A, DINELLI G, Giovanni Dinelli, Alberto Vicari, Alessandra Bonetti   +5 more
core   +1 more source

Real‐world effectiveness and safety of enavogliflozin in patients with type 2 diabetes: A 24‐week prospective multicenter observational study in Korea

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction To evaluate the real‐world effectiveness and safety of enavogliflozin as a single‐pill formulation (Enavo group; enavogliflozin 0.3 mg) or fixed‐dose combination with metformin (EnavoMet group; enavogliflozin 0.3 mg/metformin 1000 mg) in patients with type 2 diabetes (T2DM) in Korean primary care.
Hyunji Sang, Yeongtaek Hwang, Selin Woo, Soo Jin Yun, Meehoh Kim, Ho Geol Woo, Joo Young Kim, Dong Keon Yon, Sang Youl Rhee   +8 more
wiley   +1 more source

Field generation of triparental sugar beet plants through polyspermy‐induced three‐parent breeding

New Phytologist, EarlyView.
Polyspermy, the fertilization of an egg by two sperm cells, can generate viable triparental offspring in the model plant Arabidopsis thaliana. To explore the potential for three‐parent breeding in a crop species, male‐sterile sugar beet plants were grown alongside genetically distinct pollen donors carrying dominant, traceable selection markers ...
Saurabh Joshi, Christian A. Beer, Yanbo Mao, Thomas Nakel, Thomas Baum, Dawit G. Tekleyohans, Constantin Bubenheim, Joakim Palovaara, Olaf Czarnecki, Dieter Hackenberg, Rita Groß‐Hardt   +10 more
wiley   +1 more source

Transformation Kinetics and Mechanism of the Sulfonylurea Herbicides Pyrazosulfuron Ethyl and Halosulfuron Methyl in Aqueous Solutions

, 2016
Pyrazosulfuron ethyl (PE) and halosulfuron methyl (HM) are two new highly active sulfonylurea herbicides that have been widely used for weed control in a variety of vegetables and other crops.
Scott R. Yates (1414342), Wei Zheng (25452), Sharon K. Papiernik (2354329)   +2 more
core   +1 more source

Periodontal Therapy–Related Changes in Clinical Parameters, Active‐Matrix Metalloproteinase‐8 and C‐Reactive Protein in Prediabetes and Diabetes

Oral Diseases, EarlyView.
ABSTRACT Objectives This study investigated the effect of nonsurgical periodontal therapy (NSPT) on periodontal clinical parameters, active‐matrix metalloproteinase‐8 (aMMP‐8), high sensitivity C‐reactive protein (hsCRP), and glycated hemoglobin (HbA1c), and their relationships in diabetes and prediabetes patients with periodontitis.
Kehinde Adesola Umeizudike, Olayiwola Ibrahim Olaoye, Ayodele Charles Ogundana, Ismo T. Räisänen, Solomon Olusegun Nwhator, Babatunde Yusuf Alli, Patricia Omowunmi Ayanbadejo, Olufemi Adetola Fasanmade, Timo Sorsa   +8 more
wiley   +1 more source

Using the Scaffold of FDA-Approved Drugs with Trypanocidal Activity to Identify New Anti-Trypanosoma cruzi Agents: An In Silico and In Vitro Approach

Molecules
Chagas disease affects millions of people worldwide, including those in Latin America. The only drugs available for its treatment are benznidazole and nifurtimox. However, these drugs present high toxicity and limited efficacy.
Lenci K. Vázquez-Jiménez, Alonzo González-González, Timoteo Delgado-Maldonado, Rogelio Gómez-Escobedo, Guadalupe Avalos-Navarro, Adriana Moreno-Rodríguez, Alma D. Paz-González, Eyra Ortiz-Pérez, Benjamín Nogueda-Torres, Gildardo Rivera   +9 more
doaj   +1 more source