Results 31 to 40 of about 36,696 (303)

Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region

Сахарный диабет, 2015
Aim. Sulfonylureas (SU) are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM). There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic ...
Irina Arkad'evna Bondar, Maksim Leonidovich Filipenko, Olesya Yur'evna Shabel'nikova, Ekaterina Alexeevna Sokolova   +3 more
doaj   +1 more source

Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine [PDF]

, 2019
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control, it is often necessary to rely on combination therapy of multiple drugs or insulin because uncontrolled ...
Andreozzi, F, Mannino, Gc, Sesti, G
core   +1 more source

The glycemic elemental profile of trichosanthes dioica: a LIBS-based study [PDF]

, 2010
The scientific evaluation of the antidiabetic efficacy of aqueous extract of Trichosanthes dioica fruits on streptozotocin-induced diabetic rats is being presented. The graded doses of the extract, viz., 500, 750, 1,000, and 1,250 mg/kg body weight (bw),
Bicanic, D.D., Chatterji, S., Rai, N.K., Rai, P.K., Watal, G.   +4 more
core   +2 more sources

The reversible effects of free fatty acids on sulfonylurea-stimulated insulin secretion are related to the expression and dynamin-mediated endocytosis of KATP channels in pancreatic β cells

Endocrine Connections, 2022
Objective: Lipotoxicity-induced pancreatic β cell-dysfunction results in decreased insulin secretion in response to multiple stimulus. In this study, we i nvestigated the reversible effects of palmitate (PA) or oleate (OA) on insulin secretion and the ...
Chenmin Wei, Zichen Zhang, Qi Fu, Yunqiang He, Tao Yang, Min Sun   +5 more
doaj   +1 more source

Case Report: A Novel ABCC8 Variant in a Chinese Pedigree of Maturity-Onset Diabetes of the Young

Frontiers in Endocrinology, 2021
BackgroundWe aimed to analyze a novel ABCC8 variant of a Chinese patient with suspected maturity-onset diabetes of the young (MODY) and to provide evidence for precise diagnosis and appropriate treatment.MethodA Chinese family with suspected MODY was ...
Chaoyan Tang, Liheng Meng, Ping Zhang, Xinghuan Liang, Chaozhi Dang, Hui Liang, Junfeng Wu, Haiyun Lan, Yingfen Qin   +8 more
doaj   +1 more source

Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]

, 2017
ATP-sensitive potassium channels (K(ATP) channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, K(ATP) channels are essential for coupling glucose metabolism to insulin secretion.
Conway, Hannah, Emfinger, Christopher H., Moss, Jennifer B., Moss, Larry G., Nichols, Colin G., Remedi, Maria S., Wang, Yixi, Welscher, Alecia, Yan, Zihan   +8 more
core   +2 more sources

Fixed-dose combination in management of type 2 diabetes mellitus: Expert opinion from an international panel

Journal of Family Medicine and Primary Care, 2020
Type 2 diabetes mellitus (T2DM) is a progressive disease with multifactorial etiology. The first-line therapy includes monotherapy (with metformin), which often fails to provide effective glycemic control, necessitating the addition of add-on therapy. In
Sanjay Kalra, A K Das, G Priya, S Ghosh, R N Mehrotra, S Das, P Shah, S Bajaj, V Deshmukh, D Sanyal, S Chandrasekaran, D Khandelwal, A Joshi, T Nair, F Eliana, H Permana, M D Fariduddin, P K Shrestha, D Shrestha, S Kahandawa, M Sumanathilaka, A Shaheed, A A Rahim, A Orabi, A Al-ani, W Hussein, D Kumar, K Shaikh   +27 more
doaj   +1 more source

Complementary Strategy Enhancing Broad-Specificity for Multiplexed Immunoassay of Adulterant Sulfonylureas in Functional Food

Biosensors, 2022
Sulfonylureas, a family of anti-diabetic drugs widely used in the clinical treatment of type 2 diabetes, have recently emerged as an illegal adulterant in functional foods, to enhance the claimed anti-diabetic activity.
Zhaodong Li, Haihuan Xie, Tingdan Fu, Yingying Li, Xing Shen, Xiangmei Li, Yi Lei, Xiaojun Yao, Anastasios Koidis, Yingju Liu, Xinan Huang, Hongtao Lei   +11 more
doaj   +1 more source

Efeitos de herbicidas aplicados no período reprodutivo sobre o crescimento inicial de plantas daninhas na geração seguinte Effects of herbicides applied during reproductive period on initial growth of weed seedlings of the next generation

Planta Daninha, 1994
Em 1990, 91 e 92 foi conduzido experimento na Faculdade de Agronomia da UFRS, em Porto Alegre, RS, com o objetivo de avaliar os efeitos de herbicidas aspergidos durante a fase reprodutiva em balãozinho (Cardiospermum halicacabum), corriola (Ipomoea ...
André Andres, Nilson G. Flecks
doaj   +1 more source

Control of Resistant False Cleavers (Galium spurium L.) Population to ALS-Inhibiting Herbicides and Its Impact on the Growth and Yield of Durum Wheat

Agronomy, 2023
False cleavers (Galium spurium L.) is an annual broadleaf weed, commonly found in cereal crops around the world. It reduces crop yields mainly by the competition for nutrients and plant lodging, which decreases the photosynthetic rate of cultivated ...
Panagiotis Sparangis, Aspasia Efthimiadou, Nikolaos Katsenios, Anestis Karkanis   +3 more
doaj   +1 more source