Results 21 to 30 of about 22,935 (284)

StructureStability Relationship of NLRP3 Inflammasome-Inhibiting Sulfonylureas

, 2022
In recent drug development efforts, particular emphasis has been devoted to the chemical interference with the NLRP3 inflammasome. A series of 12 tailored sulfonylureas was designed, prepared through convergent syntheses with a final sodium hydride ...
Michael Marleaux, Tim Keuler, Dominic Ferber, Michael Gütschow, Matthias Geyer (29804), Michael Gütschow (1338576), Michael Marleaux (10684929), Matthias Geyer, Dominic Ferber (11575973), Tim Keuler (10684920)   +9 more
core   +1 more source

Heterocyclic Compounds as Dipeptidyl Peptidase-IV Inhibitors with Special Emphasis on Oxadiazoles as Potent Anti-Diabetic Agents

Molecules, 2022
Dipeptidyl peptidase-IV (DPP-IV) inhibitors, often known as gliptins, have been used to treat type 2 diabetes mellitus (T2DM). They may be combined with other medications as an additional treatment or used alone as a monotherapy.
Badrud Duza Mohammad, Mirza Shahed Baig, Neeraj Bhandari, Falak A. Siddiqui, Sharuk L. Khan, Zubair Ahmad, Farhat S. Khan, Priti Tagde, Philippe Jeandet   +8 more
doaj   +1 more source

A Target-Site Mutation Confers Cross-Resistance to ALS-Inhibiting Herbicides in Erigeron sumatrensis from Brazil

Plants, 2022
Cases of weed resistant to herbicides have changed the dynamics of agricultural areas in Brazil, and in recent years, Erigeron species have caused major problems to farmers in the country, mainly in relation to the ineffectiveness of herbicide treatments
Vanessa Vital Silva, Rafael Mendes, Andreia Suzukawa, Fernando Adegas, Francismar Marcelino-Guimaraes, Rubem Oliveira   +5 more
doaj   +1 more source

Effects of pre- and post-emergence weed control on weed population and maize yield in different tillage systems

Plant, Soil and Environment, 2003
The effect of chemical weed control with reduced herbicide rates (pre-em., pre-em. + post-em., post-em.) on weed population density and maize yield was compared in three tillage systems (mouldboard, chisel, disk harrowing) for lessive pseudogleyic soil ...
M. Knežević, M. Đurkić, I. Knežević, Z. Lončarić   +3 more
doaj   +1 more source

Efeito do estresse hídrico sobre a eficiência do halosulfuron no controle de tiririca Effect of water stress on halosulfuron efficacy in the control of purple nutsedge

Planta Daninha, 2000
Foi conduzido um trabalho em casa de vegetação com o objetivo de estudar o efeito de 10 dias de estresse hídrico (Yw de ³2,6; -2,2; -0,35 e -0,2 MPa) sobre a eficiência do halosulfuron (150g p.c./ha+Aterbane-0,25% v/v) no controle de tiririca em pós ...
Ricardo A. Machado, Augusto G. F. Costa, Pedro Luís C. A. Alves, Ibene T. Kawaguchi   +3 more
doaj   +1 more source

Transcription factor 7-like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetes

Journal of Medicine in Scientific Research, 2018
Background Transcription factor 7-like 2 (TCF7L2) variations were related to a modified hypoglycemic reaction to sulfonylureas (SUs) in patients with type 2 diabetes mellitus (T2D).
Ghada A Omar, Ola Sayed M. Ali, Ashraf A Ismail, Ghada S Mohamed   +3 more
doaj   +1 more source

Inpatient use of metformin and acarbose is associated with reduced mortality of COVID‐19 patients with type 2 diabetes mellitus

Endocrinology, Diabetes & Metabolism, 2022
Aims Type 2 diabetes mellitus (T2DM) is a strong risk factor for complications of coronavirus disease 2019 (COVID‐19). The effect of T2DM medications on COVID‐19 outcomes remains unclear.
Jinghong Li, Qi Wei, Karen C. McCowen, Wei Xiong, Jiao Liu, Wenlijun Jiang, Robert L. Thomas, Mark Hepokoski, Ming He, John Y. J. Shyy, Atul Malhotra, Nian Xiong, Willis X. Li   +12 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Injúria potencial de herbicidas de solo ao girassol: II - chlorimuron-ethyl Potential suflower injury by soil applied herbicides: II - chlorimuron-ethyl

Planta Daninha, 1993
Conduziu-se um ensaio de campo na Estação Experimental Agronômica da Universidade Federal do Rio Grande do Sul, em Eldorado do Sul, RS em 1989/90. O objetivo do trabalho foi determinar o efeito residual potencial do herbicida chlorimuron-ethyl aplicado ...
Nilson G. Fleck, Ribas A. Vidal
doaj   +1 more source

Pharmacoeconomic aspects of the use of sulfonylurea drugs in type 2 diabetes mellitus

Сахарный диабет, 2011
In Russia, sulfonylurea drugs are extensively prescribed to patients with type 2 diabetes mellitus. This work was designed to study pharmacoeconomicaspects of application of 2nd generation sulfonylureas based on the results of the GUIDE study comparing ...
Alla Vsevolodovna Rudakova
doaj   +1 more source