Results 31 to 40 of about 22,935 (284)

Burden and Risk Factors of CGM-Detected Hypoglycemia in Older Adults With Type 2 Diabetes. [PDF]

J Am Geriatr Soc
Among older adults with diabetes using insulin or sulfonylureas, the median time spent in hypoglycemia was 3.4% and ~66% of participants exceeded the target of < 1% time with CGM glucose < 70 mg/dL. ABSTRACT Background Comprehensive data on the burden of biochemical hypoglycemia in older adults with type 2 diabetes are lacking.
Fang M, Daya NR, Jeon Y, Echouffo-Tcheugui JB, Windham BG, Zeger S, Selvin E.   +6 more
europepmc   +2 more sources

Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region

Сахарный диабет, 2015
Aim. Sulfonylureas (SU) are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM). There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic ...
Irina Arkad'evna Bondar, Maksim Leonidovich Filipenko, Olesya Yur'evna Shabel'nikova, Ekaterina Alexeevna Sokolova   +3 more
doaj   +1 more source

Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]

, 1994
The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Wetekam, Eva-Marlen, Wied, Susanne, Pünter, Jürgen, Unkelbach, Angelika, Crecelius, Anna, Müller, Günter   +5 more
core   +1 more source

Fixed-dose combination in management of type 2 diabetes mellitus: Expert opinion from an international panel

Journal of Family Medicine and Primary Care, 2020
Type 2 diabetes mellitus (T2DM) is a progressive disease with multifactorial etiology. The first-line therapy includes monotherapy (with metformin), which often fails to provide effective glycemic control, necessitating the addition of add-on therapy. In
Sanjay Kalra, A K Das, G Priya, S Ghosh, R N Mehrotra, S Das, P Shah, S Bajaj, V Deshmukh, D Sanyal, S Chandrasekaran, D Khandelwal, A Joshi, T Nair, F Eliana, H Permana, M D Fariduddin, P K Shrestha, D Shrestha, S Kahandawa, M Sumanathilaka, A Shaheed, A A Rahim, A Orabi, A Al-ani, W Hussein, D Kumar, K Shaikh   +27 more
doaj   +1 more source

The reversible effects of free fatty acids on sulfonylurea-stimulated insulin secretion are related to the expression and dynamin-mediated endocytosis of KATP channels in pancreatic β cells

Endocrine Connections, 2022
Objective: Lipotoxicity-induced pancreatic β cell-dysfunction results in decreased insulin secretion in response to multiple stimulus. In this study, we i nvestigated the reversible effects of palmitate (PA) or oleate (OA) on insulin secretion and the ...
Chenmin Wei, Zichen Zhang, Qi Fu, Yunqiang He, Tao Yang, Min Sun   +5 more
doaj   +1 more source

Efeitos de herbicidas aplicados no período reprodutivo sobre o crescimento inicial de plantas daninhas na geração seguinte Effects of herbicides applied during reproductive period on initial growth of weed seedlings of the next generation

Planta Daninha, 1994
Em 1990, 91 e 92 foi conduzido experimento na Faculdade de Agronomia da UFRS, em Porto Alegre, RS, com o objetivo de avaliar os efeitos de herbicidas aspergidos durante a fase reprodutiva em balãozinho (Cardiospermum halicacabum), corriola (Ipomoea ...
André Andres, Nilson G. Flecks
doaj   +1 more source

Case Report: A Novel ABCC8 Variant in a Chinese Pedigree of Maturity-Onset Diabetes of the Young

Frontiers in Endocrinology, 2021
BackgroundWe aimed to analyze a novel ABCC8 variant of a Chinese patient with suspected maturity-onset diabetes of the young (MODY) and to provide evidence for precise diagnosis and appropriate treatment.MethodA Chinese family with suspected MODY was ...
Chaoyan Tang, Liheng Meng, Ping Zhang, Xinghuan Liang, Chaozhi Dang, Hui Liang, Junfeng Wu, Haiyun Lan, Yingfen Qin   +8 more
doaj   +1 more source

Synthesis of Novel 1-(4-Substituted pyridine-3-sulfonyl)-3-phenylureas with Potential Anticancer Activity

Molecules, 2015
A series of novel 4-substituted-N-(phenylcarbamoyl)-3-pyridinesulfonamides 11–27 have been synthesized by the reaction of 4-substituted pyridine-3-sulfonamides 2–10 with the appropriate aryl isocyanates in presence of potassium carbonate.
Krzysztof Szafrański, Jarosław Sławiński   +1 more
doaj   +1 more source

Complementary Strategy Enhancing Broad-Specificity for Multiplexed Immunoassay of Adulterant Sulfonylureas in Functional Food

Biosensors, 2022
Sulfonylureas, a family of anti-diabetic drugs widely used in the clinical treatment of type 2 diabetes, have recently emerged as an illegal adulterant in functional foods, to enhance the claimed anti-diabetic activity.
Zhaodong Li, Haihuan Xie, Tingdan Fu, Yingying Li, Xing Shen, Xiangmei Li, Yi Lei, Xiaojun Yao, Anastasios Koidis, Yingju Liu, Xinan Huang, Hongtao Lei   +11 more
doaj   +1 more source

The place of sulfonylureas in the therapy for type 2 diabetes mellitus

, 2006
Sulfonylureas are still largely used for treatment of type 2 diabetic patients, and they still occupy a central position in many international therapy guidelines.
Pulizzi N., Nicolò Pulizzi, DEL PRATO, STEFANO, Stefano Del Prato   +3 more
core   +1 more source