Results 31 to 40 of about 31,215 (290)

Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms [PDF]

, 2018
The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations
Grange, Dorothy K., Hanson, Alex, Josifova, Dragana, McClenaghan, Conor, Nichols, Colin G., Roessler, Helen I., Sala-Rabanal, Monica, van Haaften, Gijs   +7 more
core   +2 more sources

Fixed-dose combination in management of type 2 diabetes mellitus: Expert opinion from an international panel

Journal of Family Medicine and Primary Care, 2020
Type 2 diabetes mellitus (T2DM) is a progressive disease with multifactorial etiology. The first-line therapy includes monotherapy (with metformin), which often fails to provide effective glycemic control, necessitating the addition of add-on therapy. In
Sanjay Kalra, A K Das, G Priya, S Ghosh, R N Mehrotra, S Das, P Shah, S Bajaj, V Deshmukh, D Sanyal, S Chandrasekaran, D Khandelwal, A Joshi, T Nair, F Eliana, H Permana, M D Fariduddin, P K Shrestha, D Shrestha, S Kahandawa, M Sumanathilaka, A Shaheed, A A Rahim, A Orabi, A Al-ani, W Hussein, D Kumar, K Shaikh   +27 more
doaj   +1 more source

Complementary Strategy Enhancing Broad-Specificity for Multiplexed Immunoassay of Adulterant Sulfonylureas in Functional Food

Biosensors, 2022
Sulfonylureas, a family of anti-diabetic drugs widely used in the clinical treatment of type 2 diabetes, have recently emerged as an illegal adulterant in functional foods, to enhance the claimed anti-diabetic activity.
Zhaodong Li, Haihuan Xie, Tingdan Fu, Yingying Li, Xing Shen, Xiangmei Li, Yi Lei, Xiaojun Yao, Anastasios Koidis, Yingju Liu, Xinan Huang, Hongtao Lei   +11 more
doaj   +1 more source

Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]

, 2017
ATP-sensitive potassium channels (K(ATP) channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, K(ATP) channels are essential for coupling glucose metabolism to insulin secretion.
Conway, Hannah, Emfinger, Christopher H., Moss, Jennifer B., Moss, Larry G., Nichols, Colin G., Remedi, Maria S., Wang, Yixi, Welscher, Alecia, Yan, Zihan   +8 more
core   +2 more sources

Efeitos de herbicidas aplicados no período reprodutivo sobre o crescimento inicial de plantas daninhas na geração seguinte Effects of herbicides applied during reproductive period on initial growth of weed seedlings of the next generation

Planta Daninha, 1994
Em 1990, 91 e 92 foi conduzido experimento na Faculdade de Agronomia da UFRS, em Porto Alegre, RS, com o objetivo de avaliar os efeitos de herbicidas aspergidos durante a fase reprodutiva em balãozinho (Cardiospermum halicacabum), corriola (Ipomoea ...
André Andres, Nilson G. Flecks
doaj   +1 more source

Control of Resistant False Cleavers (Galium spurium L.) Population to ALS-Inhibiting Herbicides and Its Impact on the Growth and Yield of Durum Wheat

Agronomy, 2023
False cleavers (Galium spurium L.) is an annual broadleaf weed, commonly found in cereal crops around the world. It reduces crop yields mainly by the competition for nutrients and plant lodging, which decreases the photosynthetic rate of cultivated ...
Panagiotis Sparangis, Aspasia Efthimiadou, Nikolaos Katsenios, Anestis Karkanis   +3 more
doaj   +1 more source

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group [PDF]

, 2018
Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease.
Avery, C.L., Bis, J.C., Brody, J.A., Broer, L., Busch, E.L., Chen, Y.-DI., Cummings, S.R., Cupples, L.A., de Mutsert, R., Duan, Q., Eicher, J.D., Evans, D.S., Floyd, J.S., Gogarten, S.M., Gudnason, V., Harris, T.B., Heckbert, S.R., Johnson, A.D., Jukema, J.W., Kaplan, R.C., Kerr, K.F., Kors, J.A., Lange, L.A., Launer, L.J., Laurie, C.C., Li, J., Li, X., Li, Y., Li-Gao, R., Lin, H.J., Liu, Y., Mook-Kanamori, D.O., Méndez-Giráldez, R., Napier, M.D., Noordam, R., Psaty, B.M., Reiner, A.P., Rice, K.M., Roach, J., Rosendaal, F.R., Rotter, J.I., Sattar, N., Seyerle, A.A., Sitlani, C.M., Slagboom, P.E., Smith, A.V., Soliman, E.Z., Sotoodehnia, N., Stewart, J.D., Stott, D.J., Stricker, B.H., Stürmer, T., Taylor, K.D., Trompet, S., Uitterlinden, A.G., Whitsel, E.A., Wiggins, K.L., Wilhelmsen, K.C., Wilson, J.G.   +58 more
core   +4 more sources

Synthesis of Novel 1-(4-Substituted pyridine-3-sulfonyl)-3-phenylureas with Potential Anticancer Activity

Molecules, 2015
A series of novel 4-substituted-N-(phenylcarbamoyl)-3-pyridinesulfonamides 11–27 have been synthesized by the reaction of 4-substituted pyridine-3-sulfonamides 2–10 with the appropriate aryl isocyanates in presence of potassium carbonate.
Krzysztof Szafrański, Jarosław Sławiński   +1 more
doaj   +1 more source

Characterization of Ethoxysulfuron Herbicide Selectivity in Common Bean Cultivars [PDF]

Planta Daninha, 2018
: In literature, there are few studies evaluating the response of different bean cultivars to herbicides, particularly the ALS enzyme inhibitors. The objective of this study was to evaluate the selectivity of common bean cultivars to the herbicide ...
F.B. PAGNONCELLI JR, R.A. VIDAL, M.M. TREZZI, M. GALLON, A.P. BRUSAMARELLO   +4 more
doaj   +1 more source

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. [PDF]

, 2010
ObjectiveThe islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP).
Butler, Alexandra E, Butler, Peter C, Costes, Safia, Daval, Marie, Gurlo, Tatyana, Huang, Chang-jiang, Matveyenko, Aleksey V, Rizza, Robert A   +7 more
core   +2 more sources