Results 31 to 40 of about 18,742 (250)

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Physiological Approach to the Use of the Natural Compound Quinate in the Control of Sensitive and Resistant Papaver rhoeas

Plants, 2020
Quinate (1,3,4,5-tetrahydroxycyclohexanecarboxylate) is a compound synthesized in plants through a side-branch of the shikimate biosynthesis pathway, which is accumulated after glyphosate and acetolactate synthase inhibiting herbicides (ALS-inhibitors ...
Ana Zabalza, Ainhoa Zulet-González, Maria Barco-Antoñanzas, Mikel V. Eceiza, Miriam Gil-Monreal, Mercedes Royuela   +5 more
doaj   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Diabetes and bone. Focus on DPP-4 inhibitors

Медицинский совет, 2015
Pathology of bone homeostasis in diabetes mellitus (DM) is a significant problem that must be considered when selecting anti-diabetic therapy. Many anti-diabetic drugs have a specific effect on bone homeostasis which should be taken into account when ...
A. Y. Babenko, V. S. Nikitin, T. L. Karonova   +2 more
doaj   +1 more source

Active surveillance of drug safety in healthcare data: Sequential monitoring of bacterial and serious urinary tract infection risk in sodium‐glucose cotransporter 2 inhibitor users

British Journal of Clinical Pharmacology, EarlyView.
Abstract Introduction Active surveillance of adverse events using healthcare data is emerging as complementary to the monitoring of spontaneous reports and stand‐alone pharmacoepidemiologic studies. The risk of urinary tract infections (UTIs) was listed as a special warning for sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) when marketed in Europe
Haoxin Le, Dilsad Simay Peker, Lukas Frederic Westphal, Nikolai Brun, Christine Erikstrup Hallgreen, Morten Andersen   +5 more
wiley   +1 more source

Class-Specific Immunochromatographic Assay Enabled by Mesoporous Nanozyme-Catalyzed Signal Amplification for On-Site Screening of Sulfonylureas

Foods
Conventional immunochromatographic assays (ICAs) face limitations in sensitivity and dynamic range, hindering their application in on-site, class-specific screening of sulfonylurea (SU) adulteration in functional foods.
Yanting Li, Zixian He, Pengjie He, Zixuan Tang, Esra Bağda, Efkan Bağda, Zhenlin Xu, Xiangmei Li   +7 more
doaj   +1 more source

Seletividade do nicosulfuron em três estádios fenológicos de milho-pipoca Selectivity of nicosulfuron at three popcorn growth stages

Planta Daninha, 2012
Objetivou-se com este trabalho avaliar a seletividade do herbicida nicosulfuron em três estádios fenológicos de milho-pipoca (híbrido White A 448).
S.D. Cavalieri, F.M.L. Silva, E.D. Velini, A.R. São José, S.M. Ulloa, A. Datta, J.D. Cavalieri, S.Z Knezevic   +7 more
doaj   +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, EarlyView.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source

The place of gliclazide MB in modern treatment strategies for patients with type 2 diabetes mellitus

Сахарный диабет
Sulfonylurea (SU) are an effective class of oral hypoglycemic drugs that have been used in clinical practice for more than 70 years. Despite the common mechanism of action, members of the class have significant intraclass differences in hypoglycemic ...
N. A. Petunina, N. S. Martirosian, E. V. Goncharova, M. E. Telnova, I. A. Kuzina, A. O. Shchetinina, E. A. Elmurzaeva   +6 more
doaj   +1 more source

Response of maize (Zea mays L.) to rimsulfuron under salt conditions

Acta Societatis Botanicorum Poloniae, 2011
Investigations were carried out to determine the possible interaction between salinity (60 mmol*dm-3 NaCl) and phytotoxicity of herbicide Titus 25 DF (sulfonylurea herbicide containing active ingredient rimsulfuron).
Elżbieta Sacała, Anna Demczuk, Tomasz Michalski   +2 more
doaj   +1 more source