Results 1 to 10 of about 22,935 (284)

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome-Wide Association Studies in Individuals With Type 2 Diabetes. [PDF]

Clin Pharmacol Ther
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Breeyear JH, House JS, Kvale M, Nam S, Akhtari FS, Shah HS, Hedderson MM, Giacomini KM, Mychaleckyj JC, Doria A, Wagner MJ, Li JH, Yee SW, Buse JB, Woychik RP, Rotroff DM, Motsinger-Reif AA.   +16 more
europepmc   +2 more sources

Sulfonylureas at the Glomerular Battlefield [PDF]

European Endocrinology, 2018
The kidney is important in the context of diabetes not only because it is involved in normal glucose homeostasis, but also because it is one of the most important end organs to be involved in diabetes complications. Glomeruli are the meeting point of both microvascular, or renal; and macrovascular, or cardiovascular, health in diabetes.
Kalra, Sanjay, Khandelwal, Deepak, Bajaj, Sarita, Das, Ashok Kumar   +3 more
openaire   +2 more sources

Is it time to ban sulfonylureas?

Journal of Diabetes, 2020
n ...
openaire   +3 more sources

Sulfonylureas.

JPMA. The Journal of the Pakistan Medical Association, 2015
This review describes the basic and clinical pharmacology of sulfonylureas. It undertakes a balanced assessment of the advantages and limitations of sulfonylureas, and compares the use of various sulfonylureas in different clinical situations. The authors suggest pragmatic guidance to facilitate safe and effective use of this class of drugs, and thus ...
Sanjay, Kalra, Yashdeep, Gupta
openaire   +1 more source

The sulfonylurea receptor

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1992
Ashcroft, S, Ashcroft, F
openaire   +2 more sources

Causal association between antidiabetic drug targets and risk of Bell's palsy: A 2-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Lu K, Ye L, Yi X, He Y.
europepmc   +1 more source

GLP-1 receptor agonists and risk of all cause and cause specific acute pancreatitis: target trial emulation. [PDF]

BMJ Med
Xie Y, Choi T, Al-Aly Z.
europepmc   +1 more source

Frailty-Informed Deprescribing of Glucose-Lowering Therapy in Older Adults with Type 2 Diabetes: A Pragmatic Clinical Framework. [PDF]

Clin Interv Aging
Rangraze IR, Wali AF, Khan S, El-Tanani M, Matalka II, Rizzo M, Oo M.   +6 more
europepmc   +1 more source

Antidiabetic Drug Associations With Heart Failure Outcomes: Real-World Evidence Study Using Electronic Health Records. [PDF]

JMIR Diabetes
Jodlowska-Siewert E, Chen Y, Zhang S, Li J, Dellavalle R, Zhang R, Hou J.   +6 more
europepmc   +1 more source

Analyzing longitudinal antidiabetic medication patterns: a data-driven clustering framework. [PDF]

BMC Med Inform Decis Mak
Zhang P, Lobo JM, Sohn MW, Hallal PC, Kang H.   +4 more
europepmc   +1 more source