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Antileukemic Activity of Sulforaphane
2016The biological complexity of cancer offers numerous targets for antineoplastic therapies. Diet is a common source of biologically active compounds. Many studies demonstrated an inverse relation between the consumption of vegetables and the risk of cancer.
CATANZARO, ELENA, FIMOGNARI, CARMELA
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Thermal Degradation of Sulforaphane in Aqueous Solution
Journal of Agricultural and Food Chemistry, 1999Sulforaphane, a cancer chemopreventive agent identified from broccoli, was degraded in an aqueous solution at 50 and 100 degrees C. The reaction mixtures were extracted with methylene chloride and analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS).
Rosen, RT, Jin, Y, Wang, M, Ho, CT
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Journal of Agricultural and Food Chemistry, 2001
An extraction and preparative HPLC method has been devised to simultaneously purify sulforaphane and sulforaphane nitrile from the seed of Brassica oleracea var. italica cv. Brigadier. The seed was defatted with hexane, dried, and hydrolyzed in deionized water (1:9) for 8 h. The hydrolyzed seed meal was salted and extracted with methylene chloride. The
N V, Matusheski +5 more
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An extraction and preparative HPLC method has been devised to simultaneously purify sulforaphane and sulforaphane nitrile from the seed of Brassica oleracea var. italica cv. Brigadier. The seed was defatted with hexane, dried, and hydrolyzed in deionized water (1:9) for 8 h. The hydrolyzed seed meal was salted and extracted with methylene chloride. The
N V, Matusheski +5 more
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Theoretical investigation of sulforaphane molecule
Journal of Molecular Structure: THEOCHEM, 2005The structural and electronic properties of the broccoli sulforaphane molecule have been investigated theoretically by performing semi-empirical molecular orbital (PM3) and density functional theory calculations. The geometry of the molecule has been optimized by PM3 method and the electronic properties and the vibrational spectra of the molecule have ...
Erkoc, S, Erkoc, F
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Journal of Agricultural and Food Chemistry, 2006
Broccoli sulforaphane has received attention as a possible anticarcinogen. Sulforaphane analysis is difficult due to the lack of a chromophore for spectrometric detection. Hence, we developed a method for determining sulforaphane by using high-performance liquid chromatography (HPLC) coupled with an evaporative light-scattering detector (ELSD ...
Kiyotaka, Nakagawa +5 more
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Broccoli sulforaphane has received attention as a possible anticarcinogen. Sulforaphane analysis is difficult due to the lack of a chromophore for spectrometric detection. Hence, we developed a method for determining sulforaphane by using high-performance liquid chromatography (HPLC) coupled with an evaporative light-scattering detector (ELSD ...
Kiyotaka, Nakagawa +5 more
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Dual Roles of Sulforaphane in Cancer Treatment
Anti-Cancer Agents in Medicinal Chemistry, 2012Sulforaphane (SFN), one of naturally occurring isothiocyanates (ITCs), has huge cancer chemopreventive potential. It modulates cell death, cell cycle, angiogenesis, susceptibility to carcinogens, invasion and metastasis and possesses antioxidant activities.
Tongzhen, Xu +3 more
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