Results 191 to 200 of about 264,714 (243)

Development of an <i>in vitro</i> metabolic dysfunction-associated steatohepatitis model to investigate altered drug metabolizing enzymes, transport proteins, and hepatobiliary disposition. [PDF]

Front Pharmacol
Murphy WA, Kyburz S, Ho H, Loop MS, Fallon JK, Tiley JB, Kralj T, Brouwer KLR.   +7 more
europepmc   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

High-Temperature Properties of Hot Mix Asphalt Modified with Different Nanomaterials. [PDF]

Nanomaterials (Basel)
AlHamdo YMH, Albayati AHK, Al-Kheetan MJ.   +2 more
europepmc   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Tigloylgomisin P Inhibits Endothelial Inflammation by Regulating the NF-κB and Smad1/5/9 Pathways. [PDF]

J Lipid Atheroscler
Shin M, Ku J, Immanuel J, Kwon N, Yun S.
europepmc   +1 more source

C6-Alkoxy substituted penicillins are potent non-covalently binding inhibitors of the SARS-CoV-2 main protease. [PDF]

RSC Med Chem
Muntean DG, Treyde W, Kinena L, Salah E, Choudhry H, Duarte F, Brewitz L, Schofield CJ.   +7 more
europepmc   +1 more source

Effect of dimethyl sulfoxide pretreatment on bonding of universal adhesives to pulp chamber dentin. [PDF]

J Oral Biol Craniofac Res
Parveen Karishma Y, Nagpal R, Singh UP, Saumya S, Deshwal S.   +4 more
europepmc   +1 more source

Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity. [PDF]

Cell Death Dis
Xia C, Sun X, Shao J, Min J, Wei C, Zhao F, Fu C, Zhang Q.   +7 more
europepmc   +1 more source