Self-Sorting Microscale Compartmentalized Block Copolypeptide Hydrogels [PDF]
, 2019 Multicomponent interpenetrating network hydrogels possessing enhanced mechanical stiffness compared to their individual components were prepared via physical mixing of diblock copolypeptides that assemble by either hydrophobic association or polyion ...
Bentolila, Laurent A +2 more
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Harnessing autophagy to overcome mitogen‐activated protein kinase kinase inhibitor‐induced resistance in metastatic melanoma [PDF]
, 2019 Background Patients with malignant melanoma often relapse after treatment with BRAF and/or mitogen‐activated protein kinase kinase (MEK) inhibitors (MEKi) owing to development of drug resistance.
Alexander, M. +6 more
core +1 more source
TBK1‐Associated Primary Lateral Sclerosis Followed by Right Temporal Variant Frontotemporal Dementia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We report a 58‐year‐old woman with a novel splice‐site variant in the TANK‐binding kinase 1 (TBK1:c.993–2A>C p.Ala332TyrfsTer39) who sequentially developed primary lateral sclerosis (PLS) followed by right temporal variant frontotemporal dementia (rtvFTD). Neuroimaging demonstrated right anterior temporal atrophy before cognitive symptoms, and
Tomoyasu Matsubara +18 more
wiley +1 more source
Oxidation of Sulfides to Sulfoxides by NaBrO3-NH4Cl in Aqueous Acetonitrile [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2000 NaBrO3 combined with NH4Cl is found to be an efficient reagent for the transformation of sulfides into sulfoxides in aqueous and under mild conditions.
Ahmad Shaabani +2 more
doaj
Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons [PDF]
, 2019 Previously we reported that a group of inflammatory mediators significantly enhanced resurgent currents in dorsal root ganglion neurons. To understand the underlying intracellular signaling mechanism, we investigated the effects of inhibition of ...
Cummins, Theodore R. +6 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla +13 more
wiley +1 more source
2-Bromo-1,2-diphenylethenyl 4-methylphenyl sulfoxide
Acta Crystallographica Section E, 2009 In the title compound, C21H17BrO2S, the two phenyl rings attached to the ethene group are oriented at dihedral angles of 76.19 (10) and 57.99 (8)° with respect to the Br—C=C—S plane [r.m.s. deviation 0.003&
M. Krishnaiah +4 more
doaj +1 more source
N-terminal and C-terminal domains of calmodulin mediate FADD and TRADD interaction [PDF]
, 2015 FADD (Fas–associated death domain) and TRADD (Tumor Necrosis Factor Receptor 1-associated death domain) proteins are important regulators of cell fate in mammalian cells. They are both involved in death receptors mediated signaling pathways and have been
Balog, Edward M. +7 more
core +4 more sources
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Diclofenac solution (Pennsaid) in the management of osteoarthritis of the knee : Patient implications [PDF]
, 2009 Topical diclofenac sodium (pennsaid) is a non-steroidal-anti- inflammatory drug that is used to manage the recurrent pain and symptoms of osteoarthritis of the knee. Pennsaid is applied topically, absorbed cutaneously and concentrates locally at the site
Banning, M
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