Results 231 to 240 of about 74,360 (259)

Intracellular and Extracellular Efficacy of Homoisoflavone Derivatives Against Mycobacterium Tuberculosis: Progress Toward Novel Antitubercular Agents

ChemMedChem, EarlyView.
A series of 42 homoisoflavones were synthesized and evaluated against Mycobacterium tuberculosis (Mtb). Three derivatives showed potent inhibition of Mtb strains. Evaluation in infected macrophages revealed promising intracellular activity, where one derivative featuring a nitrofuranyl and piperidine group emerges as the most promising.
Sanderson D. Calixto, Juliane S. Falcão, Stella S. Antunes, Marlon H. Araujo, Alexandre L. B. Cunha, David R. Martins, Sarah M. R. Nascimento, Thatiana L. B. V. Simão, Elena B. Lasunskaia, Nelilma C. Romeiro, Paulo R. R. Costa, Michelle F. Muzitano, Guilherme S. Caleffi   +12 more
wiley   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Accepted Article.
Over the past decades extensive scientific research in the fields of chemistry and pharmaceutical chemistry has led to the synthesis and study of numerous chemical compounds with diverse therapeutic applications. Many of these compounds feature heterocyclic aromatic structures, including six‐, five‐, and four‐membered rings.
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Multiplex Cellular Microenvironment Detection Based on Surface‐Enhanced Raman Scattering Patch

Chemistry–Methods, EarlyView.
A multiplex patch is proposed based on surface‐enhanced Raman scattering (SERS) measurement and multivariate curve resolution (MCR) analysis. The gold nanorods (AuNRs) assembly modified on the polydimethylsiloxane (PDMS) film provides the patch with high sensitivity of SERS detection, and the MCR decomposition realizes the quantification of H2O2 and pH
Xiaoyu Wu, Zhaodong Zhang, Feng Zhu, Yuanheng Kuang, Shuqi Chen, Chongling Sun, Bohua Liu, Yanyan Wang   +7 more
wiley   +1 more source

Disposition and Absolute Bioavailability of Oral Imlunestrant in Healthy Women: A Phase 1, Open‐Label Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Imlunestrant (LY3484356) is a next‐generation orally bioavailable selective estrogen receptor degrader being investigated for the treatment of estrogen receptor–positive advanced breast and endometrial cancers. This Phase 1, open‐label, 2‐part study evaluated the disposition and absolute bioavailability of [14C]‐imlunestrant in 16 US‐based ...
Amita Datta‐Mannan, Boris Czeskis, Elaine Shanks, Eunice Yuen, Stephen Hall, Vivian Rodriguez Cruz, Kenneth Cassidy   +6 more
wiley   +1 more source

Controlling Lampenflora in Heritage Sites: In Situ Testing of Polyoxometalate–Ionic Liquids in the Pommery Champagne Cellar

ChemPlusChem, EarlyView.
The article evaluates polyoxometalate–ionic liquids (POM–ILs) as biocidal agents against lampenflora in the UNESCO‐listed Pommery Champagne cellar. POM–ILs effectively inhibit microbial colonization over one year with minimal visual impact and outperform the commercial biocide Preventol RI80.
Stéphanie Eyssautier‐Chuine, Ludovic Besaury, Nathalie Vaillant‐Gaveau, Sandra Villaume, Anouck Habrant, Isabel Franco‐Castillo, Marine Rondeau, Dina Aggad, Maxime Gommeaux, Gilles Fronteau, Scott G. Mitchell   +10 more
wiley   +1 more source

In vitro and ex vivo metabolism of diallyl disulfide, a characteristic sulfur compound of garlic, in rat.

, 2001
Emmanuelle Germain, Joëlle Chevalier, Marlène Steib, Marie Hélène Siess, Caroline Teyssier   +4 more
openalex   +1 more source

Photochemistry of Resveratrol: Beyond the Reactivity of Metal‐Free Porphyrins Immobilized on Lignin

ChemPhotoChem, EarlyView.
Resveratrol photochemistry with singlet oxygen is examined at 450 nm using blue‐LED irradiation and various homogeneous and heterogeneous photosensitizers. Products of CC bond cleavage, electrocyclic ring closure, and [4 + 2] cycloaddition are identified.
Elisa De Marchi, Alessia Marino, Fabiana Fosso, Natalia Ceccotti Vlas, Davide Piccinino, Eliana Capecchi, Lorenzo Botta, Marcello Crucianelli, Raffaele Saladino   +8 more
wiley   +1 more source

The Impact of Redox Mediators on the Electrogenic and Physiological Properties of Synechocystis sp. PCC 6803 in a Biophotovoltaic System

ChemSusChem, EarlyView.
Redox mediators are essential to promote the electrogenic activity of cyanobacteria in biophotovoltaics. In this work, we systematically evaluates three representative mediators about their influence on the cyanobacterial growth, photosynthetic efficiency, and electrogenic activity. The results reveal distinct impacts of different mediators, despite of
Jianqi Yuan, Yu Bai, Claudius Lenz, Vincent Reilly‐Schott, Hans Schneider, Bin Lai, Jens Olaf Krömer   +6 more
wiley   +1 more source

Mechanochemical Approach for Metal‐Free Regioselective C5‐Sulfenylation of Imidazo[2,1‐b]Thiazoles

ChemSusChem, EarlyView.
This study presents a mechanochemical approach for the metal‐free, regioselective C5‐sulfenylation of imidazo[2,1‐b]thiazoles using bis(trifluoroacetoxy)iodo]benzene and aryl methyl sulfides. The method, performed under solvent‐free ball‐milling conditions, provides an efficient, environmentally friendly alternative to conventional synthesis, achieving
Xinya Liu, Valentin Dorokhov, Olivier Provot, Christine Tran, Pascal Retailleau, Jean‐François Soulé, Abdallah Hamze   +6 more
wiley   +1 more source

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Metabolomics in cancer research and emerging applications in clinical oncology

Ca-A Cancer Journal for Clinicians, 2021
Daniel R Schmidt, David G Kirsch, Caroline A Lewis   +2 more
exaly