Results 1 to 10 of about 9,691 (231)

Thiosulphate sulfurtransferase: Biological roles and therapeutic potential [PDF]

Redox Biology
Mitochondria are central to eukaryotic cell function, driving energy production, intermediary metabolism, and cellular homeostasis. Dysregulation of mitochondrial function often results in oxidative stress, a hallmark of numerous diseases, underscoring ...
Yang Luo, Shaden Melhem, Martin Feelisch, Laurent Chatre, Nicholas M. Morton, Amalia M. Dolga, Harry van Goor   +6 more
doaj   +5 more sources

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284. [PDF]

FEBS Lett
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Di Napoli G, Fissore A, Salladini E, Raccuia E, Oliaro-Bosso S, Ruggiero A, Berisio R, Medina M, Velazquez-Campoy A, Adinolfi S, Marengo M.   +10 more
europepmc   +3 more sources

Ring Finger Protein 2 Promotes Oxidative Stress and Mitochondrial Dysfunction in Doxorubicin‐Induced Cardiotoxicity Via the Mercaptopyruvate Sulfurtransferase/Hydrogen Sulfide Pathway [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Doxorubicin, a broad‐spectrum chemotherapy drug, is often associated with dosage‐dependent cardiotoxicity, which results in its limited clinical application.
Yi Zhong, Di Fan, Peiyi Zhang, Xiaoxiang Mao, Baoqing Liu, Cheng Wang, Qiubai Li   +6 more
doaj   +3 more sources

Role of 3-mercaptopyruvate sulfurtransferase in cancer: Molecular mechanisms and therapeutic perspectives [PDF]

Translational Oncology
The occurrence and development of tumor is mediated by a wide range of complex mechanisms. Subsequent to nitric oxide and carbon monoxide, hydrogen sulfide (H2S) holds the distinction of being the third identified gasotransmitter.
Ka Zhang, Yi-Wen Zhu, Ao-Qi Tang, Ze-Tao Zhou, Yi-Lun Yang, Zi-Hui Liu, Yan Li, Xiao-Yi Liang, Zhi-Fen Feng, Jun Wang, Tong Jiang, Qi-Ying Jiang, Dong-Dong Wu   +12 more
doaj   +3 more sources

The Biological Consequences of the Knockout of Genes Involved in the Synthesis and Metabolism of H₂S in Drosophila melanogaster [PDF]

Antioxidants
Here, we describe the effects of double knockout (KO) of the cbs and cse genes, which are responsible for H2S synthesis through the transsulfuration pathway, and KO of the sulfurtransferase gene (dtst1) in Drosophila melanogaster females. The analysis of
Victoria Y. Shilova, David G. Garbuz, Lyubov N. Chuvakova, Alexander P. Rezvykh, Sergei Y. Funikov, Artem I. Davletshin, Svetlana Y. Sorokina, Ekaterina A. Nikitina, Olga Gorenskaya, Michael B. Evgen’ev, Olga G. Zatsepina   +10 more
doaj   +2 more sources

Oxidative Stress and Iron Addiction: A Comparative Study of 1321N1 Astrocytoma and T98G Glioblastoma Cells with Differential Expression of L-Cysteine-Metabolizing Enzymes [PDF]

Biomolecules
Gliomas are central nervous system primary tumors that are distinguished by heterogeneity, broad-based infiltration, and metabolic reprogramming that sustains proliferation, invasion, and therapy refractoriness.
Halina Jurkowska, Ewa Jasek-Gajda, Konrad Kaleta, Leszek Rydz, Dominika Szlęzak, Maria Wróbel   +5 more
doaj   +2 more sources

Methanogenesis marker 16 metalloprotein is the primary coenzyme M synthase in Methanosarcina acetivorans. [PDF]

PLoS Genetics
2-mercaptoethanesulfonate (Coenzyme M, CoM) is an organic sulfur-containing cofactor used for hydrocarbon metabolism in archaea and bacteria. In archaea, CoM serves as an alkyl group carrier for enzymes belonging to the alkyl-CoM reductase family ...
Grayson L Chadwick, Madison C Williams, Katie E Shalvarjian, Dipti D Nayak   +3 more
doaj   +2 more sources

Dual Roles of Reducing Systems in Protein Persulfidation and Depersulfidation [PDF]

Antioxidants
The oxidative modification of specific cysteine residues to persulfides is thought to be the main way by which hydrogen sulfide (H2S) exerts its biological and signaling functions. Therefore, protein persulfidation represents an important thiol-switching
Zhichao Liu, Nicolas Rouhier, Jérémy Couturier   +2 more
doaj   +2 more sources

Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes [PDF]

Biomolecules
Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective ...
Konrad Kaleta, Klaudia Janik, Leszek Rydz, Maria Wróbel, Halina Jurkowska   +4 more
doaj   +2 more sources

Expression of 3-Mercaptopyruvate Sulfurtransferase in the Mouse [PDF]

Molecules, 2016
3-Mercaptopyruvate sulfurtransferase (MST) is one of the principal enzymes for the production of hydrogen sulfide and polysulfides in mammalians, and emerging evidence supports the physiological significance of MST.
Masahiro Tomita, Noriyuki Nagahara, Takaaki Ito   +2 more
doaj   +3 more sources