Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease [PDF]
Antioxidants, 2023 3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-mercaptopyruvate
Prakashkumar Dobariya +2 more
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Activation of 3-Mercaptopyruvate Sulfurtransferase by Glutaredoxin Reducing System [PDF]
Biomolecules, 2020 Glutaredoxin (EC 1.15–1.21) is known as an oxidoreductase that protects cysteine residues within proteins against oxidative stress. Glutaredoxin catalyzes an electron transfer reaction that donates an electron to substrate proteins in the reducing system
Noriyuki Nagahara
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Expression of 3-Mercaptopyruvate Sulfurtransferase in the Mouse [PDF]
Molecules, 2016 3-Mercaptopyruvate sulfurtransferase (MST) is one of the principal enzymes for the production of hydrogen sulfide and polysulfides in mammalians, and emerging evidence supports the physiological significance of MST.
Masahiro Tomita +2 more
doaj +6 more sources
Novel Characterization of Antioxidant Enzyme, 3-Mercaptopyruvate Sulfurtransferase-Knockout Mice: Overexpression of the Evolutionarily-Related Enzyme Rhodanese [PDF]
Antioxidants, 2019 The antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase (MST, EC 2.8.1.2) is localized in the cytosol and mitochondria, while the evolutionarily-related enzyme, rhodanese (thiosulfate sulfurtransferase, TST, EC 2.8.1.1) is localized in the ...
Takaaki Ito +2 more
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Role of 3-mercaptopyruvate sulfurtransferase in cancer: Molecular mechanisms and therapeutic perspectives [PDF]
Translational OncologyThe occurrence and development of tumor is mediated by a wide range of complex mechanisms. Subsequent to nitric oxide and carbon monoxide, hydrogen sulfide (H2S) holds the distinction of being the third identified gasotransmitter.
Yi-Wen Zhu, Zhi-Fen Feng, Ao-Qi Tang
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Regulation of CyR61 expression and release by 3-mercaptopyruvate sulfurtransferase in colon cancer cells [PDF]
Redox Biology, 2022 Cysteine-rich angiogenic inducer 61 (CYR61, also termed CCN family member 1 or CCN1), is a matricellular protein encoded by the CYR61 gene. This protein has been implicated in the regulation of various cancer-associated processes including tumor growth ...
Kelly Ascenção +2 more
doaj +4 more sources
Cysteine Aminotransferase (CAT): A Pivotal Sponsor in Metabolic Remodeling and an Ally of 3-Mercaptopyruvate Sulfurtransferase (MST) in Cancer [PDF]
Molecules, 2020 Metabolic remodeling is a critical skill of malignant cells, allowing their survival and spread. The metabolic dynamics and adaptation capacity of cancer cells allow them to escape from damaging stimuli, including breakage or cross-links in DNA strands ...
Ana Hipólito +3 more
doaj +5 more sources
Targeting 3-mercaptopyruvate sulfurtransferase selectively eliminates colorectal cancer stem cells [PDF]
Redox BiologyCancer stem cells (CSCs) contribute to therapeutic resistance, metastatic progression, and tumor recurrence, yet the metabolic pathways that sustain their survival remain incompletely understood.
Kelly Ascenção +2 more
doaj +2 more sources
Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo [PDF]
Redox Biology, 2022 Increased oxidative stress and inflammation are implicated in the pathogenesis of Alzheimer's disease. Treatment with hydrogen sulfide (H2S) and H2S donors such as sodium hydrosulfide (NaSH) can reduce oxidative stress in preclinical studies, however ...
Swetha Pavani Rao +8 more
doaj +2 more sources
The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway against experimental osteoarthritis [PDF]
Arthritis Research & Therapy, 2020 Background Osteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood.
Sonia Nasi +8 more
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