Results 11 to 20 of about 18,308,335 (162)

Role of the 3-mercaptopyruvate sulfurtransferase in colon/colorectal cancers

European Journal of Cell Biology
The 3-mercaptopyruvate sulfurtransferase (MPST) is a protein persulfidase, occurring mainly in mitochondria. Although function of this protein in cancer cells has been already studied, no clear outcome can be postulated up to now.
Oľga Križanová, Andrea Soltysova, Petr Babula   +2 more
exaly   +6 more sources

Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase. [PDF]

Biochem Pharmacol, 2020
Hydrogen sulfide (H2S) is a physiological mediator that regulates cardiovascular homeostasis. Three major enzymes contribute to the generation of endogenously produced H2S, namely cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST).
Peleli M, Bibli SI, Li Z, Chatzianastasiou A, Varela A, Katsouda A, Zukunft S, Bucci M, Vellecco V, Davos CH, Nagahara N, Cirino G, Fleming I, Lefer DJ, Papapetropoulos A.   +14 more
europepmc   +9 more sources

Unraveling the role of 3-mercaptopyruvate sulfurtransferase-derived hydrogen sulfide in triple-negative breast cancer chemoresistance [PDF]

Frontiers in Pharmacology
BackgroundTriple-negative breast cancer (TNBC) frequently develops resistance to chemotherapy. Cancer-supporting roles of the endogenous gaseous mediator hydrogen sulfide (H2S) have been identified.
Sousanna Hakim, Danira A. Habashy, Kelly Ascenção, Rana A. Youness, Rana A. Youness, Carole Bourquin, Carole Bourquin, Csaba Szabo, Mohamed Z. Gad, Reham M. Abdelkader   +9 more
doaj   +3 more sources

3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics. [PDF]

Br J Pharmacol, 2020
Background and PurposeDuring angiogenesis, quiescent endothelial cells (ECs) are activated by various stimuli to form new blood vessels from pre‐existing ones in physiological and pathological conditions. Many research groups have shown that hydrogen sulfide (H2S), the newest member of the gasotransmitter family, acts as a proangiogenic factor. To date,
Abdollahi Govar A, Törő G, Szaniszlo P, Pavlidou A, Bibli SI, Thanki K, Resto VA, Chao C, Hellmich MR, Szabo C, Papapetropoulos A, Módis K.   +11 more
europepmc   +9 more sources

The Crystal Structure of Leishmania major 3-Mercaptopyruvate Sulfurtransferase [PDF]

Journal of Biological Chemistry, 2003
Leishmania major 3-mercaptopyruvate sulfurtransferase is a crescent-shaped molecule comprising three domains. The N-terminal and central domains are similar to the thiosulfate sulfurtransferase rhodanese and create the active site containing a ...
Magnus S. Alphey, Roderick A.M. Williams, Jeremy C. Mottram, Graham H. Coombs, William N. Hunter   +4 more
openaire   +2 more sources

Cerebral endothelial 3-mercaptopyruvate sulfurtransferase improves ischemia-induced cognitive impairment via interacting with protein phosphatase 2A [PDF]

Acta Pharmaceutica Sinica B
The catalytic activity of 3-mercaptopyruvate (3MP) sulfurtransferase (MPST) converts 3MP to hydrogen sulfide (H2S). However, the regulatory mechanisms governing MPST and its impact on the brain remain largely unexplored.
Li Zhu, Yi Huang, Jing Jin, Rongjun Zou, Rui Zuo, Yong Luo, Ziqing Song, Linfeng Dai, Minyi Zhang, Qiuhe Chen, Yunting Wang, Wei Wang, Rongrong He, Yang Chen   +13 more
doaj   +2 more sources

Brain 3-Mercaptopyruvate Sulfurtransferase (3MST): Cellular Localization and Downregulation after Acute Stroke. [PDF]

PLoS ONE, 2013
3-Mercaptopyruvate sulfurtransferase (3MST) is an important enzyme for the synthesis of hydrogen sulfide (H2S) in the brain. We present here data that indicate an exclusively localization of 3MST in astrocytes. Regional distribution of 3MST activities is
Heng Zhao, Su-Jing Chan, Yee-Kong Ng, Peter T-H Wong   +3 more
doaj   +2 more sources

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts [PDF]

Biomolecules, 2020
Down syndrome (trisomy of human chromosome 21) is a common genetic disorder. Overproduction of the gaseous mediator hydrogen sulfide (H2S) has been implicated in the pathogenesis of neurological and metabolic deficits associated with Down syndrome ...
Theodora Panagaki, Elisa B. Randi, Csaba Szabo   +2 more
doaj   +2 more sources

Hydrogen Sulfide From Cysteine Desulfurase, Not 3-Mercaptopyruvate Sulfurtransferase, Contributes to Sustaining Cell Growth and Bioenergetics in E. coli Under Anaerobic Conditions [PDF]

Frontiers in Microbiology, 2019
Endogenous hydrogen sulfide (H2S), which is primarily generated by 3-mercaptopyruvate sulfurtransferase (3-MST) in Escherichia coli (E. coli) under aerobic conditions, renders bacteria highly resistant to oxidative stress.
Jun Wang, Xin Guo, Heng Li, Haizhen Qi, Jing Qian, Shasha Yan, Junling Shi, Weining Niu   +7 more
doaj   +2 more sources

The expression of mercaptopyruvate sulfurtransferase serves as a potential biomarker for prognostic stratification and immunotherapy in certain cancers [PDF]

Frontiers in Oncology
Introduction3 - Mercaptopyruvate Sulfurtransferase (3 - MST) is an enzyme encoded by the Mercaptopyruvate Sulfurtransferase (MPST) gene. The enzyme is associated with a variety of cancers such as lung adenocarcinoma.
Boran Cui, Boran Cui, Chenchen Xia, Li Yang, Xiaoyu Xi, Xinxin Gong, Yixi Liu, Cai Tian, Xiaoli Du, Jiexian Du, Zengfang Hao   +10 more
doaj   +2 more sources