Results 21 to 30 of about 18,308,335 (162)

Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors [PDF]

Frontiers in Physiology
Reactive sulfur species (RSS), which include various persulfides and polysulfides, are generated by multiple enzymes in vivo and play critical roles in mammalian physiological processes such as redox signaling, metabolic regulation, radical scavenging ...
Ko Hirabayashi, Eita Sasaki, Hisashi Ohno, Orie Takayama, Sota Yamada, Kenjiro Hanaoka, Kenjiro Hanaoka   +6 more
doaj   +2 more sources

3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine β-Synthase Nor Cystathionine γ-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells [PDF]

Frontiers in Pharmacology, 2017
Hypoxia-induced angiogenesis is a common phenomenon in many physiological and patho-physiological processes. However, the potential differential roles of three hydrogen sulfide producing systems cystathionine γ-lyase (CSE)/H2S, cystathionine β-synthase ...
Beibei Tao, Rui Wang, Chen Sun, Yichun Zhu   +3 more
doaj   +2 more sources

Effect of 3‐mercaptopyruvate sulfurtransferase (3‐MST) inhibitors on contractile responses in porcine coronary artery [PDF]

British Journal of Pharmacology, Volume 182, Issue 22, Page 5453-5468, November 2025.
Background and Purpose Hydrogen sulphide (H2S) is synthesised endogenously through cystathionine β‐synthase (CBS), cystathionine γ‐lyase (CSE) and 3‐mercaptopyruvate sulfurtransferase (3‐MST). Although exogenous H2S is known to produce vasodilatation, the vascular effect of H2S produced through 3‐MST is unknown. In this study, we demonstrate the effect
Maha Almaheize, Sahar Alharthi, Patricia Hemp, Jennifer Mattos, Marcus van Leer, Michael Garle, Stephen Alexander, Richard Roberts   +7 more
wiley   +2 more sources

Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide

Biochemical Journal, 2011
H2S (hydrogen sulfide) has recently been recognized as a signalling molecule as well as a cytoprotectant. We recently demonstrated that 3MST (3-mercaptopyruvate sulfurtransferase) produces H2S from 3MP (3-mercaptopyruvate). Although a reducing substance is required for an intermediate persulfide at the active site of 3MST to release H2S, the substance ...
Yoshinori, Mikami, Norihiro, Shibuya, Yuka, Kimura, Noriyuki, Nagahara, Yuki, Ogasawara, Hideo, Kimura   +5 more
openaire   +3 more sources

Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation

Pharmacological Research
Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that occur concurrently and increase the risk of cardiovascular disease. 3-mercaptopyruvate sulfurtransferase (MPST) is a cysteine-catabolizing enzyme that yields pyruvate and hydrogen ...
Paraskevas Zampas, Zhen Li, Antonia Katsouda, Aimilia Varela, Stelios Psarras, Constantinos H. Davos, David J. Lefer, Andreas Papapetropoulos   +7 more
doaj   +3 more sources

Inhibition of the 3-mercaptopyruvate sulfurtransferase-hydrogen sulfide system promotes cellular lipid accumulation. [PDF]

Geroscience, 2022
Abstract H2S is generated in the adipose tissue by cystathionine γ-lyase, cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase (3-MST). H2S plays multiple roles in the regulation of various metabolic processes, including insulin resistance. H2S biosynthesis also occurs in adipocytes.
Casili G, Randi E, Panagaki T, Zuhra K, Petrosino M, Szabo C.   +5 more
europepmc   +3 more sources

Arabidopsis thaliana 3-mercaptopyruvate sulfurtransferases interact with and are protected by reducing systems [PDF]

Journal of Biological Chemistry, 2021
The formation of a persulfide group (-SSH) on cysteine residues has gained attention as a reversible posttranslational modification contributing to protein regulation or protection. The widely distributed 3-mercaptopyruvate sulfurtransferases (MSTs) are implicated in the generation of persulfidated molecules and H2S biogenesis through transfer of a ...
Anna Moseler, Tiphaine Dhalleine, Nicolas Rouhier, Jérémy Couturier   +3 more
openaire   +3 more sources

Characterization and interaction studies of two isoforms of the dual localized 3-mercaptopyruvate sulfurtransferase TUM1 from humans. [PDF]

J Biol Chem, 2014
Background: Localization and identification of interaction partners of two splice variants of the human 3-mercaptopyruvate sulfurtransferase TUM1.
Fräsdorf B, Radon C, Leimkühler S.
europepmc   +2 more sources

The Effects of Genetic 3-Mercaptopyruvate Sulfurtransferase Deficiency in Murine Traumatic-Hemorrhagic Shock. [PDF]

Shock, 2019
ABSTRACT Introduction: Hemorrhagic shock is a major cause of death after trauma. An additional blunt chest trauma independently contributes to mortality upon the development of an acute lung injury (ALI) by aggravating pathophysiological consequences of hemorrhagic shock.
Gröger M, Wepler M, Wachter U, Merz T, McCook O, Kress S, Lukaschewski B, Hafner S, Huber-Lang M, Calzia E, Georgieff M, Nagahara N, Szabó C, Radermacher P, Hartmann C.   +14 more
europepmc   +4 more sources

Sulfurtransferases and Cystathionine Beta-Synthase Expression in Different Human Leukemia Cell Lines

Biomolecules, 2022
The studies concerned the expression of sulfurtransferases and cystathionine beta-synthase in six human leukemia cell lines: B cell acute lymphoblastic leukemia-B-ALL (REH cells), T cell acute lymphoblastic leukemia-T-ALL (DND-41 and MOLT-4 cells), acute
Halina Jurkowska, Maria Wróbel, Ewa Jasek-Gajda, Leszek Rydz   +3 more
doaj   +1 more source