Brain 3-Mercaptopyruvate Sulfurtransferase (3MST): Cellular Localization and Downregulation after Acute Stroke [PDF]
PLoS ONE, 2013 3-Mercaptopyruvate sulfurtransferase (3MST) is an important enzyme for the synthesis of hydrogen sulfide (H2S) in the brain. We present here data that indicate an exclusively localization of 3MST in astrocytes. Regional distribution of 3MST activities is
Peter T-H Wong, Heng Zhao, Yee-Kong Ng
exaly +5 more sources
Hydrogen sulfide/polysulfides signaling and neuronal diseases [PDF]
NeurotherapeuticsHydrogen sulfide (H2S) and polysulfides including H2Sn (n = 2 or more) regulate neuronal activity, vascular tone, oxytosis/ferroptosis, oxygen sensing, cancer growth and senescence.
Hideo Kimura
exaly +4 more sources
Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide [PDF]
Scientific Reports, 2017 AbstractVery recent studies indicate that sulfur atoms with oxidation state 0 or −1, called sulfane sulfurs, are the actual mediators of some physiological processes previously considered to be regulated by hydrogen sulfide (H2S). 3-Mercaptopyruvate sulfurtransferase (3MST), one of three H2S-producing enzymes, was also recently shown to produce sulfane
Tasuku Ueno, Takuya Terai, Hideo Kimura
exaly +3 more sources
Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity [PDF]
Scientific Reports, 2023 Hydrogen sulfide (H2S) and polysulfides (H2Sn, n ≥ 2) are signaling molecules produced by 3-mercaptopyruvate sulfurtransferase (3MST) that play various physiological roles, including the induction of hippocampal long-term potentiation (LTP), a synaptic ...
Hiroki Furuie +13 more
doaj +2 more sources
Folia Pharmacologica Japonica, 2019 Hydrogen sulfide (H2S) has been reported to play an important role in biological systems. More recently, sulfane sulfur (sulfur with 0 or -1 charge) molecules have been also reported to be involved in various biological phenomena such as regulation of redox signaling and antioxidant functions.
Kenjiro Hanaoka, Honami Echizen
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Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo [PDF]
Redox Biology, 2022 Increased oxidative stress and inflammation are implicated in the pathogenesis of Alzheimer's disease. Treatment with hydrogen sulfide (H2S) and H2S donors such as sodium hydrosulfide (NaSH) can reduce oxidative stress in preclinical studies, however ...
Swetha Pavani Rao +8 more
doaj +2 more sources
Hydrogen Sulfide and Polysulfides as Biological Mediators
Molecules, 2014 Hydrogen sulfide (H2S) is recognized as a biological mediator with various roles such as neuromodulation, regulation of the vascular tone, cytoprotection, anti-inflammation, oxygen sensing, angiogenesis, and generation of mitochondrial energy.
Hideo Kimura
exaly +3 more sources
Effects of Weight-Bearing Exercise on Health-Related Physical Fitness and Sleep Indicators in Pre- and Postmenopausal Women [PDF]
운동과학, 2022 PURPOSE This study aimed to determine the effects of weight-bearing exercise on health-related physical fitness and sleep index in pre- and postmenopausal women.
Ji-Eun Lee +3 more
doaj +1 more source
Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease
Antioxidants, 2023 3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-mercaptopyruvate
Swetha Pavani Rao +3 more
doaj +1 more source