Results 31 to 40 of about 18,308,335 (162)
Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain. [PDF]
Sci Rep, 2015 AbstractHydrogen polysulfides (H2Sn) have a higher number of sulfane sulfur atoms than hydrogen sulfide (H2S), which has various physiological roles. We recently found H2Sn in the brain. H2Sn induced some responses previously attributed to H2S but with much greater potency than H2S.
Kimura Y +7 more
europepmc +4 more sources
Is Development of High-Grade Gliomas Sulfur-Dependent?
Molecules, 2014 We characterized γ-cystathionase, rhodanese and 3-mercaptopyruvate sulfurtransferase activities in various regions of human brain (the cortex, thalamus, hypothalamus, hippocampus, cerebellum and subcortical nuclei) and human gliomas with II to IV grade ...
Maria Wróbel +5 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2018 Hydrogen sulfide (H2S) is a major physiologic gastrotransmitter. Its role in the regulation of the lower esophageal sphincter (LES) function remains unknown. The present study addresses this question.
Xiaopeng Bai +11 more
doaj +1 more source
3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking
Biological Chemistry, 2020 Abstract 3-Mercaptopyruvate sulfurtransferase (MPST) catalyzes the desulfuration of 3-mercaptopyruvate to generate an enzyme-bound hydropersulfide. Subsequently, MPST transfers the persulfide’s outer sulfur atom to proteins or small molecule acceptors. MPST activity is known to be involved in hydrogen sulfide generation, tRNA thiolation,
Brandán Pedre, Tobias P. Dick
openaire +2 more sources
3‐Mercaptopyruvate sulfurtransferase represses tumour progression and predicts prognosis in hepatocellular carcinoma [PDF]
Liver International, 2022 Abstract Background and Aims The prognosis of hepatocellular carcinoma (HCC) remains dismal, and its molecular pathogenesis has not been completely defined.
Meng Li +11 more
openaire +2 more sources
Metabolism of 3-mercaptopyruvate in rat tissues. [PDF]
, 1983 Metabolism of 3-mercaptopyruvate was investigated using homogenates of rat heart, liver and kidney. When 3-mercaptopyruvate was incubated with heart homogenate, L-cysteine, L-alanine, S-(2-hydroxy-2-carboxyethylthio)-L-cysteine and 3-mercaptolactate were
Kiguchi, Shozo
core +1 more source
Generation and Characterization of a CRISPR/Cas9—Induced 3-mst Deficient Zebrafish
Biomolecules, 2020 3-mercaptopyruvate sulfurtransferase (3-MST) is an enzyme capable of synthesizing hydrogen sulfide (H2S) and polysulfides. In spite of its ubiquitous presence in mammalian cells, very few studies have investigated its contribution to homeostasis and ...
Antonia Katsouda +4 more
doaj +1 more source
Production of hydrogen sulfide from D-cysteine and its therapeutic potential
Frontiers in Endocrinology, 2013 Accumulating evidence shows that H2S has physiological functions in various tissues and organs. It includes regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney and brain from ischemic insult. H2S
Norihiro eShibuya, Hideo eKimura
doaj +1 more source
Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease
Antioxidants, 2021 Cardiovascular disease is the leading cause of death in the U.S. While various studies have shown the beneficial impact of exogenous hydrogen sulfide (H2S)-releasing drugs, few have demonstrated the influence of endogenous H2S production.
Kevin M. Casin, John W. Calvert
doaj +1 more source
Journal of Advanced Research, 2021 Background: Over the last several decades, hydrogen sulfide (H2S) has been found to exert multiple physiological functions in mammal systems. The endogenous production of H2S is primarily mediated by cystathione β-synthase (CBS), cystathione γ-lyase (CSE)
Hai-Jian Sun +4 more
doaj +1 more source