Results 111 to 120 of about 9,691 (231)

Generation and Characterization of a CRISPR/Cas9—Induced 3-mst Deficient Zebrafish

Biomolecules, 2020
3-mercaptopyruvate sulfurtransferase (3-MST) is an enzyme capable of synthesizing hydrogen sulfide (H2S) and polysulfides. In spite of its ubiquitous presence in mammalian cells, very few studies have investigated its contribution to homeostasis and ...
Antonia Katsouda, Maria Peleli, Antonia Asimakopoulou, Andreas Papapetropoulos, Dimitris Beis   +4 more
doaj   +1 more source

MTA‐TST Axis‐Mediated Apoptosis Activation: A Multi‐Omics Insight Into High‐Protein Diet's Anti‐Adiposity Effect

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
High protein diet reduced visceral adipose tissue through MTA‐TST‐Bak/Casp‐3 axis, suggesting that MTA has the potential to be developed as a functional substance for obesity prevention and control. ABSTRACT To explore the mechanism of a high‐protein diet (named high protein and rich fat diet, HPRFD) with weight loss effect regulating visceral fat ...
Xinli Yang, Yueyue Wang, Zhe Shi, Aiting Wang, Jianglan Long, Dan Yan   +5 more
wiley   +1 more source

Gasotransmitters, poisons, and antimicrobials: it's a gas, gas, gas! [PDF]

, 2013
We review recent examples of the burgeoning literature on three gases that have major impacts in biology and microbiology. NO, CO and H2S are now co-classified as endogenous gasotransmitters with profound effects on mammalian physiology and, potentially,
Jesse, H.E., Poole, R.K., Tinajero-Trejo, M.   +2 more
core   +1 more source

Cystathionine gamma‐lyase‐mediated hypoxia inducible factor 1‐alpha expression drives clear cell ovarian cancer progression

The Journal of Pathology, Volume 266, Issue 3, Page 352-367, July 2025.
Abstract Clear cell ovarian cancer (CCOC) is the second most common ovarian cancer subtype, accounting for 5%–11% of ovarian cancers in North America. Late‐stage CCOC is associated with a worse prognosis compared to other ovarian cancer histotypes, a challenge that has seen limited progress in recent decades.
Amal M EL‐Naggar, Yuqin Li, Busra Turgu, Yuchen Ding, Longyijie Wei, Shary Yuting Chen, Genny Trigo‐Gonzalez, Forouh Kalantari, Rodrigo Vallejos, Branden Lynch, Janine Senz, Amy Lum, J Maxwell Douglas, Clara Salamanca, Shelby Thornton, Yimei Qin, Kiran Parmar, Sandra E Spencer, Samuel Leung, Michelle M M Woo, Paul J Yong, Hai‐Feng Zhang, Christopher S Hughes, Gian Luca Negri, Yemin Wang, Gregg B Morin, Poul H Sorensen, David G Huntsman   +27 more
wiley   +1 more source

Role of Cystathionine Gamma-Lyase in Immediate Renal Impairment and Inflammatory Response in Acute Ischemic Kidney Injury [PDF]

, 2016
Hydrogen sulfide (H2S) is known to act protectively during renal ischemia/reperfusion injury (IRI). However, the role of the endogenous H2S in acute kidney injury (AKI) is largely unclear.
Anders, Juliane, Balogh, Andras, Filipovic, Milos R., Gollasch, Maik, Ishii, Isao, Kassmann, Mario, Kramer, Stephanie, Marko, Lajos, Mueller, Dominik N., N'diaye, Gabriele, Park, Joon-Keun, Przybyl, Lukasz, Szijarto, Istvan A.   +12 more
core   +2 more sources

Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase

Biochemical Pharmacology, 2020
Hydrogen sulfide (H2S) is a physiological mediator that regulates cardiovascular homeostasis. Three major enzymes contribute to the generation of endogenously produced H2S, namely cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST).
Maria Peleli, Sofia-Iris Bibli, Zhen Li, Athanasia Chatzianastasiou, Aimilia Varela, Antonia Katsouda, Sven Zukunft, Mariarosaria Bucci, Valentina Vellecco, Constantinos H Davos, Noriyuki Nagahara, Giuseppe Cirino, Ingrid Fleming, David J Lefer, Andreas Papapetropoulos   +14 more
openaire   +4 more sources

S‐Propargyl‐Cysteine Attenuates Stroke Heterogeneity via Promoting Protective Autophagy Across Multiple Neural Cell Types: Insights From Single‐Cell Sequencing

CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Stroke is one of the major contributors to mortality and long‐term disability. Treatments aiming at regulating endogenous protective mechanisms to reduce neurological injury after ischemic stroke are still urgently needed. Herein, we investigated the neuroprotective potential of S‐propargyl‐cysteine (SPRC), a novel water‐soluble donor of H2S, and its ...
Xiaoming Xin, Lei Miao, Lei Ci, Yun Wang, Zhiguo Zhang, Lingguo Meng, Jia Qi, Yicheng Mao, Yi‐Zhun Zhu   +8 more
wiley   +1 more source

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells

Biomolecules, 2020
3-mercaptopyruvate sulfurtransferase (3-MST) has emerged as one of the significant sources of biologically active sulfur species in various mammalian cells.
Fiona Augsburger, Elisa B. Randi, M. Jendly, Kelly Ascenção, N. Dilek, C. Szabó   +5 more
semanticscholar   +1 more source

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]

, 2012
Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Afonso, Azad, Besteiro, Betin, Betin, Bhattacharya, Boya, Cabrera, Dalle-Donne, Deretic, Dolai, Dolai, Garami, Geng, Goldman, Graef, Graham H. Coombs, Hosokawa, Jeremy C. Mottram, Kim, Kimura, Kimura, Kirisako, Kirisako, Krebiehl, Köchl, Lee, Lemasters, Li, Manjithaya, Mariño, Mariño, Mariño, Medina-Acosta, Misslitz, Mortensen, Mottram, Mörck, Mörck, Nair, Okamoto, Read, Roderick A.M. Williams, Sacks, Schapira, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Tanida, Tanida, Williams, Williams, Williams, Williams, Wong, Xie, Yoshimoto, Youle   +58 more
core   +1 more source

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source