Results 11 to 20 of about 9,691 (231)

Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease

Antioxidants, 2023
3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-mercaptopyruvate
Swetha Pavani Rao, Prakashkumar Dobariya, Harshini Bellamkonda, Swati S. More   +3 more
doaj   +2 more sources

Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain

Redox Biology, 2023
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1) was discovered as an enzyme that detoxifies cyanide by conversion to thiocyanate (rhodanide) using thiosulfate as substrate; this rhodanese activity was subsequently identified to be almost exclusively ...
Yang Luo, Laurent Chatre, Shaden Melhem, Zayana M. Al-Dahmani, Natalie Z.M. Homer, Anneke Miedema, Leo E. Deelman, Matthew R. Groves, Martin Feelisch, Nicholas M. Morton, Amalia Dolga, Harry van Goor   +11 more
doaj   +2 more sources

Effect of 3‐mercaptopyruvate sulfurtransferase (3‐MST) inhibitors on contractile responses in porcine coronary artery

British Journal of Pharmacology, Volume 182, Issue 22, Page 5453-5468, November 2025.
Background and Purpose Hydrogen sulphide (H2S) is synthesised endogenously through cystathionine β‐synthase (CBS), cystathionine γ‐lyase (CSE) and 3‐mercaptopyruvate sulfurtransferase (3‐MST). Although exogenous H2S is known to produce vasodilatation, the vascular effect of H2S produced through 3‐MST is unknown. In this study, we demonstrate the effect
Maha Almaheize, Sahar Alharthi, Patricia Hemp, Jennifer Mattos, Marcus van Leer, Michael Garle, Stephen Alexander, Richard Roberts   +7 more
wiley   +2 more sources

Regulation of CyR61 expression and release by 3-mercaptopyruvate sulfurtransferase in colon cancer cells

Redox Biology, 2022
Cysteine-rich angiogenic inducer 61 (CYR61, also termed CCN family member 1 or CCN1), is a matricellular protein encoded by the CYR61 gene. This protein has been implicated in the regulation of various cancer-associated processes including tumor growth ...
Kelly Ascenção, Bassma Lheimeur, Csaba Szabo   +2 more
doaj   +2 more sources

Glioblastoma cell motility depends on enhanced oxidative stress coupled with mobilization of a sulfurtransferase

Cell Death and Disease, 2022
Cell motility is critical for tumor malignancy. Metabolism being an obligatory step in shaping cell behavior, we looked for metabolic weaknesses shared by motile cells across the diverse genetic contexts of patients’ glioblastoma.
Mirca S. Saurty-Seerunghen, Thomas Daubon, Léa Bellenger, Virgile Delaunay, Gloria Castro, Joris Guyon, Ahmed Rezk, Sylvie Fabrega, Ahmed Idbaih, Fabien Almairac, Fanny Burel-Vandenbos, Laurent Turchi, Eric Duplus, Thierry Virolle, Jean-Michel Peyrin, Christophe Antoniewski, Hervé Chneiweiss, Elias A. El-Habr, Marie-Pierre Junier   +18 more
doaj   +2 more sources

Role of the 3-mercaptopyruvate sulfurtransferase in colon/colorectal cancers

European Journal of Cell Biology
The 3-mercaptopyruvate sulfurtransferase (MPST) is a protein persulfidase, occurring mainly in mitochondria. Although function of this protein in cancer cells has been already studied, no clear outcome can be postulated up to now.
Katarina Matyasova, Andrea Soltysova, Petr Babula, Olga Krizanova, Veronika Liskova   +4 more
doaj   +2 more sources

Cysteine Signalling in Plant Pathogen Response. [PDF]

Plant Cell Environ
ABSTRACT The amino acid cysteine is the precursor for a wide range of sulfur‐containing functional molecules in plants, including enzyme cofactors and defence compounds. Due to its redox active thiol group cysteine is highly reactive. Synthesis and degradation pathways are present in several subcellular compartments to adjust the intracellular cysteine
Moormann J, Heinemann B, Angermann C, Koprivova A, Armbruster U, Kopriva S, Hildebrandt TM.   +6 more
europepmc   +2 more sources

Structural and functional characterization of sulfurtransferase from Frondihabitans sp. PAMC28461. [PDF]

PLoS ONE
Sulfurtransferases transfer of sulfur atoms from thiols to acceptors like cyanide. They are categorized as thiosulfate sulfurtransferases (TSTs) and 3-mercaptopyruvate sulfurtransferases (MSTs). TSTs transfer sulfur from thiosulfate to cyanide, producing
Hackwon Do, Dieu Linh Nguyen, Yong-Yoon Ahn, Yewon Nam, YoonJi Kang, HoeJung Oh, Jisub Hwang, Se Jong Han, Kitae Kim, Jun Hyuck Lee   +9 more
doaj   +2 more sources

The Role of Thiosulfate Sulfurtransferase in Oxidative Stress for Type 2 Diabetes Mellitus

Сахарный диабет
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with oxidative stress, leading to insulin resistance. Thiosulfate sulfurtransferase (TST) is mitochondrial enzyme involved in the reaction with cyanide, endogenous hydrogen sulfide (H₂S), and ...
M. M. Mawajdeh, T. A. Allwsh
doaj   +2 more sources

Thiosulfate sulfurtransferase prevents hyperglycemic damage to the zebrafish pronephros in an experimental model for diabetes

Scientific Reports, 2022
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, was initially discovered as a cyanide detoxification enzyme. However, it was recently also found to be a genetic predictor of resistance to obesity-related type 2 diabetes ...
Zayana M. Al-Dahmani, Xiaogang Li, Lucas M. Wiggenhauser, Hannes Ott, Paul D. Kruithof, Sergey Lunev, Fernando A. Batista, Yang Luo, Amalia M. Dolga, Nicholas M. Morton, Matthew R. Groves, Jens Kroll, Harry van Goor   +12 more
doaj   +2 more sources