Results 71 to 80 of about 9,691 (231)
Parasitology Research, 2022 In Leishmania sp., the enzymes of de novo cysteine biosynthesis pathway require sulfide. Other organisms utilize sulfide through the sulfide reduction pathway, but Leishmania lacks the gene that encodes these enzymes.
V. Kant +5 more
semanticscholar +1 more source
Escherichia coli Uses Separate Enzymes to Produce H2S and Reactive Sulfane Sulfur From L-cysteine
Frontiers in Microbiology, 2019 Hydrogen sulfide (H2S) has been proposed to have various physiological functions, and it may function through reactive sulfane sulfur. Since the two sulfur forms often coexist, they are normally considered interchangeable.
Kai Li +7 more
doaj +1 more source
H2S, Polysulfides, and Enzymes: Physiological and Pathological Aspects
Biomolecules, 2020 We have been studying the general aspects of the functions of H2S and polysulfides, and the enzymes involved in their biosynthesis, for more than 20 years.
Noriyuki Nagahara, Maria Wróbel
doaj +1 more source
GeroScience, 2022 H2S is generated in the adipose tissue by cystathionine γ-lyase, cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase (3-MST). H2S plays multiple roles in the regulation of various metabolic processes, including insulin resistance.
Giovanna Casili +5 more
semanticscholar +1 more source
Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics [PDF]
, 2016 Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H(2)S) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H(2)S) producing ...
Druzhyna, Nadiya +7 more
core +1 more source
Lifespan‐Extending Endogenous Metabolites
Aging Cell, Volume 25, Issue 2, February 2026.Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley +1 more source
Antioxidants, 2022 Recently, a CRISPR-Cas9 genome-editing system was developed with introduced sequential ‘driver’ mutations in the WNT, MAPK, TGF-β, TP53 and PI3K pathways into organoids derived from normal human intestinal epithelial cells.
Kelly Ascenção +5 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 1, January 2026.ATIs in cereal seeds link to celiac disease, asthma, and immune response. Here, we report the first study exploring genetic factors affecting ATI levels in barley. GWAS identified multiple QTNs influencing ATI accumulation with notable variation. Eight QTNs are associated with lower ATI levels; a key gene was identified.
Dalia Z. Alomari +8 more
wiley +1 more source
Identification of sulfurtransferase enzymes in Azotobacter vinelandii [PDF]
FEBS Letters, 1991 Rhodanese and 3‐mercaptopyruvate sulphurtransferase have been identified in A. vinelandii. Two distinct active fractions of the two sulphurtransferases were obtained after FPLC ion‐exchange chromatography of material partially purified from crude extracts. Rhodanese has been purified to homogeneity, and it consists of one polypeptide chain of M r ca 25
Pagani, S. +3 more
openaire +2 more sources
NRF2 signalling in cytoprotection and metabolism
British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami +4 more
wiley +1 more source