Journal of Experimental Medicine, 2022 Katsouda et al. describe the impact of the sulfide species–generating enzyme MPST in energy homeostasis and metabolic health. Mpst−/− mice placed on high-fat diet exhibit attenuated mitochondrial protein import, mitochondrial dysfunction, enhanced lipid ...
A. Katsouda +14 more
semanticscholar +1 more source
Intestinal barrier tightening by a cell-penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis. [PDF]
, 2018 Patients afflicted with ulcerative colitis (UC) are at increased risk of colorectal cancer. While its causes are not fully understood, UC is associated with defects in colonic epithelial barriers that sustain inflammation of the colon mucosa caused by ...
Alexander, Walker +8 more
core +2 more sources
Supersulfide biology and translational medicine for disease control
British Journal of Pharmacology, Volume 183, Issue 1, Page 115-130, January 2026.Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu +5 more
wiley +1 more source
Purified dietary red and white meat proteins show beneficial effects on growth and metabolism of young rats compared to casein and soy protein [PDF]
, 2018 This study compared the effects of casein, soy protein (SP), red (RMP) and white meat (WMP) proteins on growth and metabolism of young rats. Compared to casein, the ratio of daily feed intake to daily body weight gain of rats was not changed by meat ...
Fu, Qingquan +8 more
core +4 more sources
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology [PDF]
, 2018 The chemical biology of thiols (RSH, e.g., cysteine and cysteine‐containing proteins/peptides) has been a topic of extreme interest for many decades due to their reported roles in protein structure/folding, redox signaling, metal ligation, cellular ...
Akaike Takaaki +13 more
core +2 more sources
Physiological Reports, Volume 13, Issue 24, December 2025.Abstract Perivascular adipose tissue (PVAT) regulates vascular tone, and high‐fat diets reportedly lead to the loss of its anti‐contractile properties. Methionine restriction recapitulates many caloric restriction metabolic effects and increases liver expression of activating transcription factor 4 (ATF4) and downstream targets with anti‐contractile ...
Adam Corken +4 more
wiley +1 more source
Scientific opinion on the acute health risks related to the presence of cyanogenic glycosides in raw apricot kernels and products derived from raw apricot kernels [PDF]
, 2016 Peer reviewedPublisher ...
core +3 more sources
Regulation of the T-type Ca²⁺ channel Cav3.2 by hydrogen sulfide: Emerging controversies concerning the role of H₂S in nociception [PDF]
, 2015 Ion channels represent a large and growing family of target proteins regulated by gasotransmitters such as nitric oxide, carbon monoxide and, as described more recently, hydrogen sulfide.
Abe +102 more
core +2 more sources
Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley +1 more source