Results 71 to 80 of about 163,760 (356)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Randomly Stopped Sums, Minima and Maxima for Heavy-Tailed and Light-Tailed Distributions
AxiomsThis paper investigates the randomly stopped sums, minima and maxima of heavy- and light-tailed random variables. The conditions on the primary random variables, which are independent but generally not identically distributed, and counting random ...
Remigijus Leipus +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Silva Fennica, 1997 Models for individual-tree basal area growth were constructed for Scots pine ( L.), pubescent birch ( Ehrh.) and Norway spruce ( (L.) Karst.) growing in drained peatland stands.
Hökkä, Hannu +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Limit distributions of maximum vertex degree in a conditional configuration graph
Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2018 We consider configuration graphs with N vertices. The degrees of the vertices are independent identically distributed random variables following the power-law distribution with positive parameter τ.
Irina Cheplyukova
doaj +1 more source
Efficient Importance Sampling for Large Sums of Independent and\n Identically Distributed Random Variables [PDF]
, 2021 Nadhir Ben Rached +3 more
openalex +1 more source
Approximation Results for Sums of Independent Random Variables
Revstat Statistical Journal, 2020 In this article, we consider Poisson and Poisson convoluted geometric approximation to the sums of $n$ independent random variables under moment conditions. We use Stein's method to derive the approximation results in total variation distance. The error bounds obtained are either comparable to or improvement over the existing bounds available in the ...
openaire +4 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source