Results 81 to 90 of about 168,667 (308)

Independent Variables with Independent Sum and Difference: S1-Case

, 1993
A classic result in probability theory states that two independent real-valued random variables having independent sum and difference are either constant or normally distributed with the same variance.
Stadje, W., Eisenberg, B., Baryshnikov, Y.   +2 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Randomly Stopped Sums, Minima and Maxima for Heavy-Tailed and Light-Tailed Distributions

Axioms
This paper investigates the randomly stopped sums, minima and maxima of heavy- and light-tailed random variables. The conditions on the primary random variables, which are independent but generally not identically distributed, and counting random ...
Remigijus Leipus, Jonas Šiaulys, Svetlana Danilenko, Jūratė Karasevičienė   +3 more
doaj   +1 more source

Individual-tree basal area growth models for Scots pine, pubescent birch and Norway spruce on drained peatlands in Finland.

Silva Fennica, 1997
Models for individual-tree basal area growth were constructed for Scots pine ( L.), pubescent birch ( Ehrh.) and Norway spruce ( (L.) Karst.) growing in drained peatland stands.
Hökkä, Hannu, Alenius, Virpi, Penttilä, Timo   +2 more
doaj   +1 more source

Small deviation probabilities for sums of independent positive random variables

, 2020
We examine an asymptotic behavior at zero of distributions and densities of a sum of several independent positive random variables under certain assumptions on the decay rate of their distributions at zero. We consider the cases, when the distributions
Rozovsky, Leonid V.
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

On the sum of independent zero-truncated poisson random variables

, 2006
: The objective of this article is to derive the density function and cumulative distribution function for random variables which may be written as the sum of independent (either identical or non-identical) zerotruncated Poisson random variables.
van Nieuwenhuyse, Inneke, Springael, Johan   +1 more
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Limit distributions of maximum vertex degree in a conditional configuration graph

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2018
We consider configuration graphs with N vertices. The degrees of the vertices are independent identically distributed  random variables following the power-law distribution with positive parameter τ.
Irina Cheplyukova
doaj   +1 more source