Results 101 to 110 of about 168,667 (308)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Lundberg-type inequality for an inhomogeneous renewal risk model
Modern Stochastics: Theory and Applications, 2015 We obtain a Lundberg-type inequality in the case of an inhomogeneous renewal risk model. We consider the model with independent, but not necessarily identically distributed, claim sizes and the interoccurrence times.
Ieva Marija Andrulytė +3 more
doaj +1 more source
A Note on the Sum of Uniform Random Variables
, 2009 An inductive procedure is used to obtain distributions and probability densities for the sum $S_n$ of independent, non equally uniform random variables. Some known results are then shown to follow immediately as special cases.
PIROZZI, ENRICA +2 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Limit theorems for random Dirichlet series: boundary case
Modern Stochastics: Theory and ApplicationsBuraczewski et al. (2023) proved a functional limit theorem (FLT) and a law of the iterated logarithm (LIL) for a random Dirichlet series ${\textstyle\sum _{k\ge 2}}\frac{{(\log k)^{\alpha }}}{{k^{1/2+s}}}{\eta _{k}}$ as $s\to 0+$, where $\alpha \gt -1/2$
Alexander Iksanov, Ruslan Kostohryz
doaj +1 more source
Weak convergence to the t-distribution [PDF]
We present a new limit theorem for random means: if the sample size is not deterministic but has a negative binomial or geometric distribution, the limit distribution of the normalised random mean is a t-distribution with degrees of freedom depending on ...
Mark Trede, Christian Schluter
core
Necessary and sufficient conditions for weak convergence of random sums of independent random variables [PDF]
, 1993 summary:Let $\{X_n,\, n\geq 1\}$ be a sequence of independent random variables such that $EX_n=a_n$, $E(X_n-a_n)^2=\sigma _n^2$, $n\geq 1$. Let $\{N_n,\, n\geq 1\}$ be a sequence od positive integer-valued random variables. Let us put $S_{N_n}=\sum_{k=1}^
Krajka, A., Rychlik, Z.
core