Results 91 to 100 of about 129,441 (306)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Quiet Sun Explosive Events: Jets, Splashes, and Eruptions

, 2012
Explosive events are small transition region phenomena characterised by broad non-Gaussian wings in their line profiles. Images from the Solar Dynamics Observatory (SDO) give a first view of the plasma dynamics at the sites of explosive events seen in O ...
Innes, Davina, Teriaca, Luca
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

New views on the emission and structure of the solar transition region

, 2010
The Sun is the only star that we can spatially resolve and it can be regarded as a fundamental plasma laboratory of astrophysics. The solar transition region (TR), the layer between the solar chromosphere and corona, plays an important role in solar wind
Aiouaz, Aiouaz, Athay, Athay, Axford, Bartoe, Bartoe, Bartoe, Basri, Bocchialini, Bohlin, Bonnet, Brekke, Brosius, Brosius, Brosius, Brown, Brueckner, Brueckner, Brueckner, Brynildsen, Büchner, Büchner, Chae, Chae, Chae, Chen, Chen, Chen, Chuanyi Tu, Culhane, Curdt, Curdt, Curdt, Curdt, Curdt, Curdt, Dammasch, Dammasch, De Pontieu, Del Zanna, Dere, Dere, Dere, Doschek, Doschek, Doschek, Dowdy, Doyle, Doyle, Doyle, Doyle, Eckart Marsch, Evershed, Evershed, Falconer, Fang, Feldman, Feldman, Feldman, Fontenla, Fontenla, Foukal, Foukal, Foukal, Gabriel, Golub, Gontikakis, Gouttebroze, Gouttebroze, Griffiths, Gunár, Guo, Habbal, Hansteen, Hansteen, Harra, Harrison, Harrison, Hassler, He, He, He, Heinzel, Hui Tian, Hénoux, Ichimoto, Imada, Innes, Innes, Jiansen He, Jin, Jordan, Katsukawa, Kneer, Lemaire, Lemaire, Lemaire, Li, Liu, Longcope, Madjarska, Madjarska, Magara, Mariska, Mariska, Marsch, Marsch, Marsch, Marsch, Marsch, Marsch, McClymont, McIntosh, McIntosh, McIntosh, McIntosh, Metcalf, Nicolas, Nicolas, Parnell, Patsourakos, Peter, Peter, Peter, Peter, Peter, Popescu, Priest, Raju, Ravindra, Reeves, Sakao, Santos, Schmieder, Schrijver, Seehafer, Sheeley, Solanki, Stucki, Teriaca, Teriaca, Teriaca, Teriaca, Teriaca, Teriaca, Tian, Tian, Tian, Tian, Tian, Tian, Tian, Tian, Tian, Tian, Tian, Tian, Tu, Tu, Tu, Ugarte-Urra, Ugarte-Urra, Ugarte-Urra, Vernazza, Vernazza, Vial, Vial, Vial, Wang, Wang, Warren, Watanabe, Webb, Werner Curdt, Wiegelmann, Wiegelmann, Wiegelmann, Wilhelm, Wilhelm, Wilhelm, Wilhelm, Wilhelm, Xia, Xia, Xia, Xu, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang   +192 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Hydrogen Lyman emission through the solar cycle

, 2010
We present observations and results of radiance and irradiance studies completed by SoHO-SUMER during the past solar cycle. We find that the cycle variation in Ly-alpha irradiance as observed by e.g.
Curdt, W., Tian, H.
core  

Observations of a rotating macrospicule associated with an X-ray jet

, 2010
We attempt to understand the driving mechanism of a macrospicule and its relationship with a coronal jet. We study the dynamics of a macrospicule and an associated coronal jet captured by multi-spacecraft observations.
B. Inhester, Canfield, Cirtain, Culhane, Culhane, Domingo, Golub, Habbal, Howard, Kaiser, Kim, Kosugi, L. Teriaca, Moore, Nisticò, Pariat, Patsourakos, Pike, Raouafi, S. K. Solanki, S. Kamio, Savcheva, Schmieder, Shibata, Shimojo, Shimojo, Tian, W. Curdt, Wilhelm, Yokoyama, Young   +30 more
core   +1 more source

Effect of magnetized water on the germination of Cotton seeds (Gossypium hirsutum L.) under different conditions of saline stress

Kufa Journal for Agricultural Sciences, 2018
      A laboratory experiment was designed with two factors by using completely randomized design (CRD) with three replicates to determine the effect of saline stress and magnetized water on the germination of cotton seeds.
Saba Ali Alzubaidi
doaj  

Fuzzy decision-tree regression model and its application to measure some climate change factors

Frontiers in Applied Mathematics and Statistics
In this paper, we considered a new study that examines the topic of climate change based on data from two important variables: temperature and wind speed.
Ali Salman Habeeb, Hussein A. Hasan, Adnan M. Al-Sinjary   +2 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source