Results 61 to 70 of about 3,991 (249)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Quasi β-power increasing sequences
International Journal of Mathematics and Mathematical Sciences, 2004 We prove a theorem of Mazhar (1999) on |N¯,pn|k summability factors under weaker conditions by using a quasi β-power increasing sequence instead of an almost increasing sequence.
H. Bor, L. Debnath
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
, 2014 This is a continuation of developing mutation theory in exact WKB analysis using the framework of cluster algebras. Here we study the Schrodinger equation on a compact Riemann surface with turning points of simple-pole type.
Iwaki, Kohei, Nakanishi, Tomoki
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Quasimonotone and Almost Increasing Sequences and Their New Applications
Abstract and Applied Analysis, 2012 Recently, we have proved a main theorem dealing with the absolute Nörlund summability factors of infinite series by using -quasimonotone sequences. In this paper, we prove that result under weaker conditions. A new result has also been obtained.
Hüseyin Bor
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Power Increasing Sequences and Their Some New Applications
Abstract and Applied Analysis, 2012 In the work of Bor (2008), we have proved a result dealing with summability factors by using a quasi--power increasing sequence. In this paper, we prove that result under less and more weaker conditions. Some new results have also been obtained.
Hüseyin Bor
doaj +1 more source