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Biochemical Society Transactions, 2007
Post-translational modification of cellular proteins by the SUMO (small ubiquitin-related modifier) is involved in numerous modes of regulation in widely different biological processes. In contrast with ubiquitination, SUMO conjugation is highly specific in terms of target lysine residues, but many aspects of substrate and lysine selection by the SUMO ...
J. Anckar, L. Sistonen
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Post-translational modification of cellular proteins by the SUMO (small ubiquitin-related modifier) is involved in numerous modes of regulation in widely different biological processes. In contrast with ubiquitination, SUMO conjugation is highly specific in terms of target lysine residues, but many aspects of substrate and lysine selection by the SUMO ...
J. Anckar, L. Sistonen
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2010
Sumoylation, the covalent attachment of SUMO peptide to cellular proteins, is an essential regulator of protein function involved in a wide range of cellular events. Deregulation of the SUMO pathway is implicated in the pathogenesis of several diseases, so it is important to understand how this system is controlled.
Katharina, Maderböck, Andrea, Pichler
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Sumoylation, the covalent attachment of SUMO peptide to cellular proteins, is an essential regulator of protein function involved in a wide range of cellular events. Deregulation of the SUMO pathway is implicated in the pathogenesis of several diseases, so it is important to understand how this system is controlled.
Katharina, Maderböck, Andrea, Pichler
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SUMO Conjugation and SUMO Chain Formation by Plant Enzymes
2022SUMO conjugation is a conserved process of eukaryotes, and essential in metazoa. Similar to ubiquitylation, a SUMO-activating enzyme links to the SUMO carboxyl-terminal Gly in a thioester bond, and a SUMO-conjugating enzyme accepts activated SUMO and can transfer it to substrates.
Tomanov, Konstantin +3 more
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SUMO conjugation and deconjugation
Molecular and General Genetics MGG, 2000Ligation of the ubiquitin-like protein SUMO (Smt3p) to other proteins is essential for viability of the yeast Saccharomyces cerevisiae. Like ubiquitin (Ub), SUMO undergoes ATP-dependent activation by a specific activating enzyme. SUMO-activating enzyme is a heterodimer composed of Uba2p and Aos1p, polypeptides with sequence similarities, respectively ...
Ingrid Schwienhorst +2 more
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Molecular mechanisms in SUMO conjugation.
Biochemical Society Transactions, 2019The small ubiquitin-like modifier (SUMO) is a post-translational modifier that can regulate the function of hundreds of proteins inside the cell. SUMO belongs to the ubiquitin-like family of proteins that can be attached to target proteins by a dedicated
N. Varejão +3 more
semanticscholar +1 more source
2009
Mitosis is the stage of the cell cycle during which replicated chromosomes must be precisely divided to allow the formation of two daughter cells possessing equal genetic material. Much of the careful spatial and temporal organization of mitosis is maintained through post-translational modifications, such as phosphorylation and ubiquitination, of key ...
Debaditya Mukhopadhyay, Mary Dasso
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Mitosis is the stage of the cell cycle during which replicated chromosomes must be precisely divided to allow the formation of two daughter cells possessing equal genetic material. Much of the careful spatial and temporal organization of mitosis is maintained through post-translational modifications, such as phosphorylation and ubiquitination, of key ...
Debaditya Mukhopadhyay, Mary Dasso
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Analysis of Cellular SUMO and SUMO–Ubiquitin Hybrid Conjugates
2012Posttranslational modification of proteins with the small ubiquitin-related modifier (SUMO) has been implicated in many important physiological functions, including the regulation of transcription and DNA repair. In most cases, only a small fraction of the total cellular amounts of a given protein is sumoylated at a certain point in time.
Gerrit J. K. Praefcke +7 more
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Nature Reviews Microbiology, 2010
Listeria monocytogenes interferes with host defence pathways by inhibiting host protein sumoylation.
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Listeria monocytogenes interferes with host defence pathways by inhibiting host protein sumoylation.
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SUMO and Nucleocytoplasmic Transport
2009The transport of proteins between the nucleus and cytoplasm occurs through nuclear pore complexes and is facilitated by numerous transport factors. These transport processes are often regulated by post-translational modification or, reciprocally, transport can function to control post-translational modifications through regulated transport of key ...
Christopher Ptak, Richard W. Wozniak
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Proteostasis and SUMO in the heart
The International Journal of Biochemistry & Cell Biology, 2016Heart proteostasis relies on a complex and integrated network of molecular processes surveilling organ performance under physiological and pathological conditions. For this purpose, cardiac cells depend on the correct function of their proteolytic systems, such as the ubiquitin-proteasome system (UPS), autophagy and the calpain system.
Elisa Da Silva-Ferrada +3 more
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