Nuclear processes associated with plant immunity and pathogen susceptibility [PDF]
, 2015 Plants are sessile organisms that have evolved exquisite and sophisticated mechanisms to adapt to their biotic and abiotic environment. Plants deploy receptors and vast signalling networks to detect, transmit and respond to a given biotic threat by ...
Huitema, Edgar +3 more
core +3 more sources
DLD‐HLNP/P@IR780 for efficient lung‐parenchyma accumulation to treat idiopathic pulmonary fibrosis
VIEW, EarlyView.DLD‐HLNP/P@IR780 was synthesized to target to lung and treat IPF by releasing pirfenidone. It could effectively traverse pulmonary ECB and accumulate in lung parenchyma by IR780 binding to CD300LF and MRC1 which are abundantly and specifically expressed on pulmonary endothelial cell and pulmonary macrophages.
Mengzhu Wang +3 more
wiley +1 more source
Activity, stability and 3-D structure of the Cu(II) form of a chitin-active lytic polysaccharide monooxygenase from Bacillus amyloliquefaciens [PDF]
, 2016 The enzymatic deconstruction of recalcitrant polysaccharide biomass is central to the conversion of these substrates for societal benefit, such as in biofuels.
Aachmann +48 more
core +2 more sources
SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends
Advances in Experimental Medicine and Biology, 2019 SUMO is a ubiquitin-like protein that covalently binds to lysine residues of target proteins and regulates many biological processes such as protein subcellular localization or stability, transcription, DNA repair, innate immunity, or antiviral defense ...
Ahmed El Motiam +5 more
semanticscholar +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
MMS21/HPY2 and SIZ1, two Arabidopsis SUMO E3 ligases, have distinct functions in development.
PLoS ONE, 2012 The small ubiquitin related modifier (SUMO)-mediated posttranslational protein modification is widely conserved among eukaryotes. Similar to ubiquitination, SUMO modifications are attached to the substrate protein through three reaction steps by the E1 ...
Takashi Ishida +3 more
doaj +1 more source
Role of the Bifunctional Aminoacyl-tRNA Synthetase EPRS in Human Disease [PDF]
, 2020 Aminoacyl-tRNA synthetases (AARS) are a class of enzymes that catalyze the charging of tRNAs with cognate amino acids, a critical step that contributes to the fidelity of protein synthesis.
Kudlapur, Nathan
core
Slx5/Slx8-dependent ubiquitin hotspots on chromatin contribute to stress tolerance [PDF]
, 2019 Chromatin is a highly regulated environment, and protein association with chromatin is often controlled by post-translational modifications and the corresponding enzymatic machinery.
Habermann, B. +6 more
core +3 more sources
Liquid–Liquid Phase Separation in Major Hallmarks of Cancer
Cell Proliferation, EarlyView.Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie +10 more
wiley +1 more source
The polySUMOylation axis promotes nucleolar release of Tof2 for mitotic exit
Cell ReportsSummary: In budding yeast, the nucleolus serves as the site to sequester Cdc14, a phosphatase essential for mitotic exit. Nucleolar proteins Tof2, Net1, and Fob1 are required for this sequestration.
Emily Gutierrez-Morton +5 more
doaj +1 more source