Writing and erasing MYC ubiquitination and SUMOylation
Genes and Diseases, 2019 The transcription factor c-MYC (MYC thereafter) controls diverse transcription programs and plays a key role in the development of many human cancers. Cells develop multiple mechanisms to ensure that MYC levels and activity are precisely controlled in ...
Yingxiao Chen +3 more
doaj +1 more source
Human FASTK preferentially binds single‐stranded and G‐rich RNA
The FEBS Journal, EarlyView.Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak +7 more
wiley +1 more source
Proteomic Study of SUMOylation During Solanum tuberosum–Phytophthora infestans Interactions
Molecular Plant-Microbe Interactions, 2017 Invasive plant pathogens have developed the ability to modify the metabolism of their host, promoting metabolic processes that facilitate the growth of the pathogen at the general expense of the host.
Bertrand Colignon +6 more
doaj +1 more source
The Mdm-2 Amino Terminus Is Required for Mdm2 Binding and SUMO-1 Conjugation by the E2 SUMO-1 Conjugating Enzyme Ubc9 [PDF]
, 2001 Thomas Buschmann +3 more
openalex +1 more source
Regulation of axon repulsion by MAX-1 SUMOylation and AP-3. [PDF]
, 2018 During neural development, growing axons express specific surface receptors in response to various environmental guidance cues. These axon guidance receptors are regulated through intracellular trafficking and degradation to enable navigating axons to ...
Chen, Shih-Yu +6 more
core
The FEBS Journal, EarlyView.Enzymes from the phosphodiesterase type 4 family (PDE4) coordinate physiological events driven by the cyclic AMP s(cAMP) signaling pathway by tightly controlling cAMP dynamics in many cell types. Key to this strict regulation is the myriad of posttranslational modifications that alter PDE4 activity, cellular location, and binding partner selection ...
Madihah Hussain +2 more
wiley +1 more source
Transcriptional regulation of human topoisomerase II beta : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]
, 2006 Pages 24 and 25 are missing from the original copy.Topoisomerase II has an essential role in maintaining the DNA in the correct topological state required for various cellular processes.
Mawson, Claire
core
Unconventional structure and function of PHD domains from additional sex combs‐like proteins
The FEBS Journal, EarlyView.A plant homeodomain (PHD) at the C terminus of additional sex combs‐like (ASXL) proteins is recurrently truncated in disease. In the current study, the ASXL PHD was shown not to bind histone modifications. Instead, a complex between the ASXL PHD and methyl CpG‐binding domain proteins 5 and 6 (MBD5/6) was investigated.
Cameron J. Reddington +4 more
wiley +1 more source
SUMO1 modification of 0N4R-tau is regulated by PIASx, SENP1, SENP2, and TRIM11
Biochemistry and Biophysics ReportsTau is a microtubule-associated protein that contributes to cytoskeletal stabilization. Aggregation of tau proteins is associated with neurodegenerative disorders such as Alzheimer's disease.
Harmony Wada +2 more
doaj +1 more source