Results 171 to 180 of about 1,958,325 (325)
The Role of E1 SUMO Activating Enzyme in the Development of Drosophila melanogaster [PDF]
, 2011 SUMOylation is an Ubiquitin-like post-translational modification thought to affect a diverse array of cellular processes, from chromosome segregation to nuclear translocation. The E1 SUMO-activating enzyme is required for the earliest steps of SUMO conjugation, and is composed of heterodimeric Aosl and Uba2 subunits.
openaire +2 more sources
TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models
The FEBS Journal, EarlyView.The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir +7 more
wiley +1 more source
p14ARF Interacts with the SUMO-Conjugating Enzyme Ubc9 and Promotes the Sumoylation of Its Binding Partners [PDF]
, 2005 Nadia Barboule +2 more
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Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]
, 2012 Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core
Ubiquitin and SUMO conjugation as biomarkers of acute myeloid leukemias response to chemotherapies
Life Science Alliance, 2019 This study describes the identification of a new class of biomarkers of cancer response to therapies based on protein modification by ubiquitin and SUMO and developed tools to validate them in acute myeloid leukemia patient samples.
P. Gâtel +7 more
semanticscholar +1 more source
The FEBS Journal, EarlyView.Using cryo‐EM combined with biochemical and genetic approaches, we mapped the interaction surface between NifL and NifA to gain insights into the regulation of nitrogen fixation genes in A. vinelandii. Our findings suggest that NifL, a homolog of histidine kinases lacking phosphorylation activity, evolved to act as a steric block of NifA activity ...
Marcelo Bueno Batista +6 more
wiley +1 more source
SUMO-Conjugating and SUMO-Deconjugating Enzymes from Arabidopsis [PDF]
GBM Fall meeting Hamburg 2007, 2007 Thomas Colby +2 more
openaire +2 more sources
Targeting the SUMO E1‐E2 Enzyme Interaction in Plasmodium falciparum
The FASEB Journal, 2015 Resistance to first‐line anti‐malarial drugs has accelerated the need for new drugs with novel targets for effective malaria treatment. Many of the current anti‐malarial drugs work in part by overwhelming the parasite stress response. In eukaryotes, the oxidative stress response machinery includes antioxidants as well as SUMOylation, a post ...
Jürgen Bosch +2 more
openaire +2 more sources
Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation
The FEBS Journal, EarlyView.This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley +1 more source
Journal of Integrative Plant Biology, EarlyView.Clade A protein phosphatases of type 2C PP2Cs dephosphorylate B3 RAF kinases at a conserved serine residue critical for ATP binding, thereby maintaining their basal activity. Under stress, RAFs rapidly autophosphorylate this residue for autoinhibition.
Chen Zhu +8 more
wiley +1 more source