Results 221 to 230 of about 1,958,325 (325)

Construction of a mouse Aos1-Uba2 chimeric SUMO-E1 enzyme, mAU, and its expression in baculovirus-insect cells [PDF]

, 2014
Tomofumi Nakayama, Eri Yuasa, Ayumi Kanemaru, Masayuki Saito, Hisato Saitoh   +4 more
openalex   +1 more source

Auto-sumoylation of the Ubc9 E2 SUMO-conjugating Enzyme Extends Cellular Lifespan

Abstract Calorie restriction (CR) provides anti-aging benefits through diverse processes, such as reduced metabolism and growth and increased mitochondrial activity. Although controversy still exists regarding CR-mediated lifespan effects, many researchers are seeking interventions that mimic the effects of CR.
Hong-Yeoul Ryu, Dong-Won Jeong, Seung Yeon Kim, Seok-Won Jeoung, Dejian Zhao, James Knight, TuKiet Lam, Jong Hwa Jin, Hyun-Shik Lee, Mark Hochstrasser   +9 more
openaire   +2 more sources

A third type of PETase from the marine Halopseudomonas lineage

Protein Science, Volume 34, Issue 10, October 2025.
Abstract The enzymatic degradation of polyethylene terephthalate (PET) offers a sustainable solution for PET recycling. Over the past two decades, more than 100 PETases have been characterized, primarily exhibiting similar sequences and structures.
Onur Turak, Andreas Gagsteiger, Ashank Upadhyay, Mark Kriegel, Peter Salein, Stefanie Böhnke‐Brandt, Seema Agarwal, Erik Borchert, Birte Höcker   +8 more
wiley   +1 more source

SUMOylation balance: a key determinant in synapse physiology. [PDF]

Front Physiol
Bertozzi A, Toscanelli W, Castellitto G, Grassi C, Colussi C.   +4 more
europepmc   +1 more source

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

British Journal of Pharmacology, Volume 182, Issue 20, Page 4876-4893, October 2025.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding, Chengqing Ning, Shao‐Ru Chen, Hao‐Ran Yin, Jing Xu, Ying Wang   +5 more
wiley   +1 more source

Identification of SUMO Proteins and Their Expression Profile During Induction of Somatic Embryogenesis in <i>Medicago truncatula</i> Gaertn. [PDF]

Int J Mol Sci
Kujawska A, Król P.
europepmc   +1 more source

SUMOylation of ZEB1 Modulates PANoptosis in Burn‐Induced Early Acute Kidney Injury

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Burn‐induced acute kidney injury (AKI) involves inflammatory programmed cell death pathways, including PANoptosis. This study investigated how SUMOylation of the transcription factor ZEB1 regulates PANoptosis in early burn‐induced AKI. Human AKI datasets were analyzed for ZEB1 expression and correlation with PANoptosis/SUMOylation genes. A rat
Juncheng Zhang, Zhengjie Huang, Qin Lin, Hongbin Zhong, Weiping Hu, Fengling Zhang, Jiyi Huang   +6 more
wiley   +1 more source

Unraveling the critical role of SUMOylation in the governing of tumor immunity. [PDF]

Front Immunol
Liu X, Ding W, Jiang L, Chen Q, Luo X.
europepmc   +1 more source

Phase 1b/2 Study of the First-in-Class SUMO-Activating Enzyme Inhibitor TAK-981 in Combination with Monoclonal Antibodies in Patients with Triple-Class Refractory Multiple Myeloma

, 2021
Sagar Lonial, Stefano Tarantolo, Ralph V. Boccia, Habte Yimer, Moshe Levy, Rafat Abonour, Meera Mohan, Vivek Roy, Jeremy T. Larsen, Saulius Girnius, Cara A. Rosenbaum, Omar Nadeem, Deborah Berg, Bo H. Chao, Allison Berger, Akito Nakamura, Yuhong Zhang, Keli Song, Christine K. Ward, Igor Proscurshim, Shaji Kumar   +20 more
openalex   +1 more source

Rice black‐streaked dwarf virus‐encoded P6 protein impairs OsPelota‐mediated antiviral RNA decay defense via promoting OsSCE1b ubiquitination and degradation in rice

Journal of Integrative Plant Biology, Volume 67, Issue 10, Page 2760-2777, October 2025.
The P6 protein encoded by rice black‐streaked dwarf virus enhances degradation of the rice SUMO E2 conjugating enzyme OsSCE1b through the ubiquitin/26S proteasome pathway; OsSCE1b degradation results in decreased SUMOylation of OsPelota, thereby suppressing RNA decay‐dependent antiviral defenses in rice. ABSTRACT Rice black‐streaked dwarf virus (RBSDV)
Yi Xie, Ming Zeng, Dan Wang, Shi‐bo Gao, Liyan Li, Lianshun Zheng, Yunge Zhang, Shifang Fei, Cui Zhang, Yaqin Wang, Xueping Zhou, Jianxiang Wu   +11 more
wiley   +1 more source