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SUMO Conjugation and SUMO Chain Formation by Plant Enzymes
2022SUMO conjugation is a conserved process of eukaryotes, and essential in metazoa. Similar to ubiquitylation, a SUMO-activating enzyme links to the SUMO carboxyl-terminal Gly in a thioester bond, and a SUMO-conjugating enzyme accepts activated SUMO and can transfer it to substrates.
Tomanov, Konstantin +3 more
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The SUMO activating enzyme subunit, SAE2, contributes SUMO protein bias for mitotic fidelity
2022Abstract Mammalian cells possess three conjugatable SUMO variants: SUMO1 and the largely indistinguishable SUMO2 and SUMO3 (designated SUMO2/3). Some SUMOylated substrates are modified by both SUMO1 and SUMO2/3, while others show biased modifications towards SUMO1 or SUMO2/3.
Alexandra K. Walker +7 more
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SUMO Ubc9 enzyme as a viral target.
IUBMB life, 2014Viruses alter specific host cell targets to counteract possible defense mechanisms aimed at eliminating infectivity and viral propagation. The SUMO conjugating enzyme Ubc9 functions as a hub for protein sumoylation, whilst also providing an interactive surface for sumoylated proteins through noncovalent interactions.
Varadaraj A., Mattoscio D., Chiocca S.
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A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly
Nature Structural & Molecular Biology, 2015SUMO chains act as stress-induced degradation tags or repair factor-recruiting signals at DNA lesions. Although E1 activating, E2 conjugating and E3 ligating enzymes efficiently assemble SUMO chains, specific chain-elongation mechanisms are unknown.
Nathalie Eisenhardt +10 more
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SUMO Chain Formation by Plant Enzymes
2016SUMO conjugation is a conserved process of eukaryotes, and essential in metazoa. Different isoforms of SUMO are present in eukaryotic genomes. Saccharomyces cerevisiae has only one SUMO protein, humans have four and Arabidopsis thaliana has eight, the main isoforms being SUMO1 and SUMO2 with about 95 % identity.
Tomanov, Konstantin +2 more
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Expression and regulation of the mammalian SUMO‐1 E1 enzyme
The FASEB Journal, 2001ABSTRACT SUMO‐1 is a small ubiquitin‐related protein. SUMO‐1 conjugation requires enzymes with sequence and biochemical similarity to ubiquitin E1 and E2 enzymes. We have examined the expression, localization, and biochemical behavior of Aos1 and Uba2, subunits of the mammalian SUMO‐1 E1 enzyme. Both of these proteins are expressed in
Y, Azuma +5 more
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Biochemical characterization of SUMO-conjugating enzymes by in vitro sumoylation assays
2019The small ubiquitin-related modifier (SUMO) is a protein of ~10kDa that is covalently conjugated to its substrate proteins in an enzymatic process called sumoylation. This posttranslational modification is an essential regulatory mechanism that plays crucial roles in many cellular pathways.
Eisenhardt, Nathalie +3 more
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Targeting the SUMO E2 Conjugating Enzyme Ubc9 Interaction for Anti-Cancer Drug Design
Anti-Cancer Agents in Medicinal Chemistry, 2009Sumoylation has been implicated in a variety of cancers, suggesting that sumoylation manipulation could be one approach for regulating tumorgenesis. Ubc9 exerts a central function for the sumoylation pathway, interacting with almost all the partners required for sumoylation.
Xinyuan, Duan, John O, Trent, Hong, Ye
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Sequence Search and Comparative Genomic Analysis of SUMO-Activating Enzymes Using CoGe
2016The growing number of genome sequences completed during the last few years has made necessary the development of bioinformatics tools for the easy access and retrieval of sequence data, as well as for downstream comparative genomic analyses. Some of these are implemented as online platforms that integrate genomic data produced by different genome ...
Lorenzo, Carretero-Paulet +1 more
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