Results 61 to 70 of about 4,081 (158)

Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction

EMBO Reports
Brain aging is an intricate process that inevitably leads to functional deterioration. However, its molecular drivers remain unclear. Here, we show that the age-related decline in LINC complex expression on the neuronal nuclear envelope impairs axon ...
Koichi Hasegawa, Noriyuki Hama, Mina Amemiya, Chao Zeng, Yasuyuki Ito, Sadafumi Suzuki, Keiichiro Nakamura, Junpei Kondo, Chiharu Takeda, Yuji Kurihara, Kazuho Ikeda, Yuki Fujita, Yasushi Okada, Atsushi Toyoda, Michiaki Hamada, Ken-ichiro Kuwako   +15 more
doaj   +1 more source

Herb‐Based Extracellular Vesicles for Infectious Disease

Small Structures, Volume 7, Issue 5, May 2026.
Chinese herbal medicine‐derived extracellular vesicles‐like particles (CHM‐EVLPs) are presented as innovative nanomedicines for infectious diseases. This review highlights their diverse therapeutic effects, including pathogen clearance, immune modulation, microbiota regulation and tissue barrier repairment, unlocking a powerful natural material against
Erjia Weng, Zhi‐Chao Sun, Yuntao Liu, Ran Liao, Ran Lin, Yan Zhang, Xi Zhang, Minghua Tang, Kaichun Yang, Xiaolu Wang, Wen Huang, Zhongde Zhang, Xiaotu Xi, Jun Wu   +13 more
wiley   +1 more source

Rényi Entropy for the $\sun1$ WZW model on the torus

, 2015
v4.
openaire   +2 more sources

Altered Brain Structure in an ATRX‐Deficient Mouse Model of Autism Spectrum Disorder

Autism Research, Volume 19, Issue 4, April 2026.
ABSTRACT Mutations in the ATRX gene are a primary cause of alpha‐thalassemia intellectual disability X‐linked (ATRX) syndrome, which is characterized by intellectual disability, autism, and a range of brain structural abnormalities, including microcephaly.
Katherine Quesnel, Jacob Ellegood, Jason P. Lerch, Nathalie G. Bérubé   +3 more
wiley   +1 more source

Quantum spin models for the SU(n)1 Wess–Zumino–Witten model

Nuclear Physics B, 2014
We propose 1D and 2D lattice wave functions constructed from the SU(n)1 Wess–Zumino–Witten (WZW) model and derive their parent Hamiltonians. When all spins in the lattice transform under SU(n) fundamental representations, we obtain a two-body Hamiltonian
Hong-Hao Tu, Anne E.B. Nielsen, Germán Sierra   +2 more
doaj   +1 more source

Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides

Cells, 2018
The mammalian nuclear lamina proteins—prelamin A- and B-type lamins—are post-translationally modified by farnesylation, endoproteolysis, and carboxymethylation at a carboxy-terminal CAAX (C, cysteine; a, aliphatic amino acid; X, any amino ...
Xiang Lu, Karima Djabali
doaj   +1 more source

Samp1 Mislocalization in Emery-Dreifuss Muscular Dystrophy

Cells, 2018
LMNA linked-Emery-Dreifuss muscular dystrophy (EDMD2) is a rare disease characterized by muscle weakness, muscle wasting, and cardiomyopathy with conduction defects.
Elisabetta Mattioli, Marta Columbaro, Mohammed Hakim Jafferali, Elisa Schena, Einar Hallberg, Giovanna Lattanzi   +5 more
doaj   +1 more source

P53 | CIRCADIAN DEPENDENT MOTILITY: THE ROLE FOR THE PERINUCLEAR ACTIN CAP

European Journal of Histochemistry
The circadian rhythm is responsible for the regulation of the daynight cycle by release of several factors, including the master regulator glucocorticoids (GCs). Previous studies reveal that the GCs dampen the transcriptional response to EGFR activation,
doaj   +1 more source

A computational pipeline for identifying gene targets and signalling pathways in cancer cells to improve lymphocyte infiltration and immune checkpoint therapy efficacyResearch in context

EBioMedicine
Summary: Background: Tumour-infiltrating lymphocytes (TILs) are crucial for effective immune checkpoint blockade (ICB) therapy in solid tumours. However, ∼70% of these tumours exhibit poor lymphocyte infiltration, rendering ICB therapies less effective.
Sahar Nasr, Lin Li, Mohammad Asad, Mahroo Moridi, Megan Wang, Franz J. Zemp, Douglas J. Mahoney, Edwin Wang   +7 more
doaj   +1 more source

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source