Results 141 to 150 of about 871,767 (331)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

NTIRE 2022 Challenge on Super-Resolution and Quality Enhancement of Compressed Video: Dataset, Methods and Results [PDF]

, 2022
Ren Yang, Radu Timofte, Meisong Zheng, Qunliang Xing, Minglang Qiao, Mai Xu, Lai Jiang, Huaida Liu, Ying Chen, Youcheng Ben, Xiaofang Zhou, Chen Fu, Cheng Pei, Gang Yu, Junyi Li, Renlong Wu, Zhilu Zhang, Wei Shang, Zhengyao Lv, Yunjin Chen, Mingcai Zhou, Dongwei Ren, Kai Zhang, Wangmeng Zuo, Pavel Ostyakov, Dmitry Vyal, Shakarim Soltanayev, Sergey Chervontsev, Magauiya Zhussip, Xueyi Zou, Youliang Yan, Pablo Navarrete Michelini, Yunhua Lu, Diankai Zhang, Shaoli Liu, Si Gao, Biao Wu, Chengjian Zheng, Xiaofeng Zhang, Kaidi Lu, Ning Wang, Thuong Nguyen Canh, Thong Bach, Qing Wang, Xiaopeng Sun, Haoyu Ma, Shijie Zhao, Junlin Li, Liangbin Xie, Shuwei Shi, Yujiu Yang, Xintao Wang, Jinjin Gu, Chao Dong, Xiaodi Shi, Chunmei Nian, Dong Jiang, Jucai Lin, Zhihuai Xie, Mao Ye, Dengyan Luo, Liuhan Peng, Shengjie Chen, Xin Liu, Qian Wang, Xin Liu, Boyang Liang, Hang Dong, Yuhao Huang, Kai Chen, Xingbei Guo, Yujing Sun, Huilei Wu, Pengxu Wei, Yulin Huang, Junying Chen, Ik Hyun Lee, Sunder Ali Khowaja, Jiseok Yoon   +78 more
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Joint Natural Awareness and Spatial-Frequency Attention Lightweight Network for Super-Resolution Image Quality Assessment

, 2022
Hui Li, Tingyue Zhang, Kaibing Zhang
openalex   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Hand Motion Estimation using Super-Resolution of Multipoint Surface Electromyogram by Deep Learning [PDF]

, 2022
Keigo FUKUSHIMA, Yoshiaki YASUMURA
openalex   +1 more source

Seeing in super-resolution [PDF]

Nature Methods, 2014
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

SBHSR: single-band super-resolution method for hyperspectral images based on blind degradation and fusion of auxiliary band

Geocarto International
Despite natural image super-resolution (SR) methods have achieved great success, super-resolution methods for hyperspectral image (HSI) with rich spectral features are still a very challenging task.
Lijing Bu, Xi Xiao, Zhengpeng Zhang, Deng Mingjun   +3 more
doaj   +1 more source