Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure [PDF]
Pharmaceutics, 2022 Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever.
Audrey Yi Zheng +2 more
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Sodium Starch Glycolate (SSG) from Sago Starch (Metroxylon sago) as a Superdisintegrant: Synthesis and Characterization [PDF]
Molecules, 2023 The characteristics of sago starch exhibit remarkable resemblances to those of cassava, potato, and maize starches. This review intends to discuss and summarize the synthesis and characterization of sodium starch glycolate (SSG) from sago starch as a ...
Okta Nama Putra +6 more
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The Influence of the Intergranular Superdisintegrant Performance on New Drotaverine Orodispersible Tablet Formulations [PDF]
Pharmaceutics, 2023 The main objective of this study consists in establishing the influence of the intergranular superdisintegrant on the specific properties of drotaverine hydrochloride fast-dissolving granules (DROT-FDGs) and orodispersible tablets (DROT-ODTs).
Robert-Alexandru Vlad +7 more
doaj +2 more sources
In Vitro/In Vivo Evaluation of Clomipramine Orodispersible Tablets for the Treatment of Depression and Obsessive-Compulsive Disorder [PDF]
Pharmaceuticals, 2023 The first and only antidepressant drug on the market with solid proof of clinically significant serotonin and noradrenaline reuptake inhibition is clomipramine (CLP). However, significant first-pass metabolism reduces its absorption to less than 62%.
Shazia Akram Ghumman +9 more
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Preparation and Evaluation of Directly Compressible Orally Disintegrating Tablets of Cannabidiol Formulated Using Liquisolid Technique [PDF]
Pharmaceutics, 2022 This study demonstrated the implementation of a liquisolid technique to formulate directly compressible orally disintegrating tablets (ODTs). Cannabidiol (CBD), a hydrophobic cannabinoid, was prepared as a liquisolid powder using microcrystalline ...
Ekapol Limpongsa +3 more
doaj +2 more sources
Formulation and In Vitro Evaluation of Pellets Containing Sulfasalazine and Caffeine to Verify Ileo-Colonic Drug Delivery [PDF]
Pharmaceutics, 2021 The ColoPulse coating is a pH-dependent coating that can be used to target drug release to the ileo-colonic region. ColoPulse coated tablets and capsules have demonstrated their targeting capabilities in vivo in more than 100 volunteers and patients ...
Annemarie Broesder +5 more
doaj +2 more sources
FORMULASI SEDIAAN ORALLY DISINTEGRATING TABLET ATENOLOL DENGAN SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRAN [PDF]
Jurnal Farmasi Sains dan Komunitas, 2017 Atenolol, a competitive beta (1)-selective adrenergic antagonists, has been widely used in hypertension therapy. Administration of conventional tablets of atenolol has limitation due to patient compliance in geriatric patients. Formulation of atenolol as
Karina Citra Rani +2 more
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Utjecaj superdezintegratora na oslobađanje efavirenca iz tableta [PDF]
Acta Pharmaceutica, 2010 Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different ...
B. Preetha +17 more
core +5 more sources
Scalable flibanserin nanocrystal-based novel sublingual platform for female hypoactive sexual desire disorder: engineering, optimization adopting the desirability function approach and in vivo pharmacokinetic study [PDF]
Drug Delivery, 2021 Flibanserin (FLB) was approved by FDA for the treatment of pre-menopausal female hypoactive sexual desire disorder (HSDD). FLB suffers from low oral bioavailability (33%) which might be due to hepatic first-pass metabolism in addition to its poor aqueous
Marianne J. Naguib, Amal I. A. Makhlouf
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Formulation and evaluation of orally disintegrating tablet of ondansetron using natural superdisintegrant [PDF]
Journal of HerbMed Pharmacology, 2015 Introduction: Difficulty in swallowing is common among all age groups, especially elderly and pediatrics. Orally disintegrating tablets may constitute an innovative dosage form that overcome the problem of swallowing and provide a quick onset of action ...
Shahtalebi Mohammad Ali +2 more
doaj +4 more sources