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Basic Introduction and Mechanism of Action of Superdisintegrants
International Journal of Recent Research and Review, 2023The ideal dispersion of an oral solid dose form is into the primary particles from which it was made. The proper disintegrant must be used in tablets and capsules that require quick disintegration in order to achieve maximum bioavailability. Solid dose forms are more effective when superdisintegrants are utilised.
Aarti Mehta +3 more
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Natural Superdisintegrant: Opportunity in Oral Drug Delivery System
Asian Journal of Pharmacy and Technology, 2021The present work concerned with formulation and evaluation of fast disintegrating tablet of Topiramate by using natural superdisintegrants like Trigonellafoenum graceum (fenugreek) powder, Plantago ovata powder, dehydrated banana powder, soy polysaccharide, linseed powder. Topiramate is an antiepileptic drug and also used in migraine.
Rina G. Maskare +6 more
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Chitin–silicon dioxide coprecipitate as a novel superdisintegrant
Journal of Pharmaceutical Sciences, 2008Chitin-silica represents a potentially useful superdisintegrant in many pharmaceutical applications. The "intimate" association between chitin and silica, without evidence of chemical reaction, creates an insoluble, hydrophilic, highly absorbent inert material.
Iyad, Rashid +3 more
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Characterization of chitin–metal silicates as binding superdisintegrants
Journal of Pharmaceutical Sciences, 2009When chitin is used in pharmaceutical formulations, processing of chitin with metal silicates is advantageous, from both an industrial and pharmaceutical perspective, compared to processing using silicon dioxide. Unlike the use of acidic and basic reagents for the industrial preparation of chitin-silica particles, coprecipitation of metal silicates is ...
Iyad, Rashid +5 more
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Superdisintegrants used in pharmaceutical technology
Česká a slovenská farmacie, 2018Disintegrants are substances which promote disintegration of the solid dosage form in the dissolution medium or body fluids. Efficient disintegration is an important prerequisite for ensuring release of the active substance and its good bioavailability.
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Comparative study of natural disintegrants, selection criteria for superdisintegrants
World Journal of Pharmaceutical Sciences, 2022Natural super disintegrants have been used for fast dissolving tablets because they are biodegradable, chemically inert, non-harmful, more affordable and widely available. The natural polymer improves the properties of the tablet as it is commonly used as diluents and binders.
Sonu Kanaujiya, Sunil Kumar
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Water content determination of superdisintegrants by means of ATR-FTIR spectroscopy
Journal of Pharmaceutical and Biomedical Analysis, 2012Water contents of superdisintegrant pharmaceutical excipients were determined by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy using simple linear regression. Water contents of the investigated three common superdisintegrants (crospovidone, croscarmellose sodium, sodium starch glycolate) varied over a wide range (0-24%,
G, Szakonyi, R, Zelkó
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Recent Strategic Developments in the Use of Superdisintegrants for Drug Delivery
Current Pharmaceutical Design, 2020Improving drug bioavailability in the pharmaceutical field is a challenge that has attracted substantial interest worldwide. The controlled release of a drug can be achieved with a variety of strategies and novel materials in the field. In addition to the vast development of innovative materials for improving therapeutic effects and reducing side ...
Phuong H.L. Tran, Thao T.D. Tran
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International Journal of Biological Macromolecules, 2014
Psyllium husk (Plantago ovata, Family: Plantaginaceae) contains a high proportion of hemicellulose, composed of a xylan backbone linked with arabinose, rhamnose, and galacturonic acid units (arabinoxylans). Polysaccharide was isolated from Psyllium husk using solvent precipitation method.
Harshal, Pawar, Chhaya, Varkhade
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Psyllium husk (Plantago ovata, Family: Plantaginaceae) contains a high proportion of hemicellulose, composed of a xylan backbone linked with arabinose, rhamnose, and galacturonic acid units (arabinoxylans). Polysaccharide was isolated from Psyllium husk using solvent precipitation method.
Harshal, Pawar, Chhaya, Varkhade
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A new approach to determining the performance of superdisintegrants
Journal of Bioactive and Compatible Polymers, 2014Superdisintegrants are used in some tablet formulations to improve water penetration and disintegration, leading to improved drug dissolution rates. The extremely fast speeds at which superdisintegrants perform their functions have made it difficult to evaluate differences in their disintegration properties.
Joshi, Yogesh N. +3 more
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