Results 41 to 50 of about 1,751 (191)

Recent Trends in developments of Superdisintegrants: An Overview

Journal of Drug Delivery and Therapeutics, 2022
Fast dissolving tablets are solid unit dosage forms that dissolve or disintegrate quickly in the mouth without using water. To provide this type of character in a dosage form, different excipients are required. Superdisintegrants are a class of novel agents that have emerged in recent years. Improving drug bioavailability in the pharmaceutical field is
D.N. Prasad, Dhruv Dev, Nisha Rani
openaire   +2 more sources

Role of Superdisintegrants in Rapid Dissolving Oral Films

International Journal of Pharmaceutical Sciences Review and Research, 2022
Rapid dissolving oral film is the most advanced solid oral drug delivery system, that dissolve or disintegrate with in few seconds once placed in mouth without taking water or chewing. Drug directly reaches into systemic circulation therefore avoids first pass metabolism so bioavailability of medication may be improved. Now a days most of the pediatric,
Shruthi BK, Dr V. Chandrakala, S. Srinivasan   +2 more
openaire   +1 more source

Optimization of Chitosan and Cellulose Acetate Phthalate Controlled Delivery of Methylprednisolone for Treatment of Inflammatory Bowel Disease [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: Inflammatory bowel disease (IBD) is a chronic, relapsing and often life-long disorder. The best way to tackle IBD is to develop a site targeted drug delivery. Methylprednisolone is a potent anti-inflammatory steroid.
Swati Jagdale, Apoorva Chandekar
doaj   +1 more source

Enhancement of the Solubility and Dissolution Rate of Telmisartan by Surface Solid Dispersions Employing Superdisintegrants, Hydrophilic Polymers and Combined Carriers

Scientia Pharmaceutica, 2022
Telmisartan (Tel) is a potent antihypertensive drug with a very poor aqueous solubility, especially in pH ranging from 3 to 9 (i.e., biological fluids) that results in poor bioavailability.
Reem A. Aldeeb, Mohamed Farid El-Miligi, Mohamed El-Nabarawi, Randa Tag, Hany M. S. Amin, A. A. Taha   +5 more
doaj   +1 more source

Physicochemical interactions between drugs and superdisintegrants

Journal of Pharmacy and Pharmacology, 2008
Abstract We have evaluated the interactions between superdisintegrants and drugs with different physicochemical characteristics, which may affect the in-vivo absorption e.g. after mucosal administration. The binding of sodium salicylate, naproxen, methyl hydroxybenzoate (methylparaben), ethyl hydroxybenzoate (ethylparaben), propyl ...
Nelly, Fransén, Malin, Morin, Erik, Björk, Katarina, Edsman   +3 more
openaire   +2 more sources

Re‐evaluation of polyvinylpyrrolidone (E 1201) and polyvinylpolypyrrolidone (E 1202) as food additives and extension of use of polyvinylpyrrolidone (E 1201)

EFSA Journal, Volume 18, Issue 8, August 2020., 2020
Abstract The present opinion deals with the re‐evaluation of polyvinylpyrrolidone (E 1201, PVP) and polyvinylpolypyrrolidone (E 1202, PVPP) when used as food additives. One request for extension of use of PVP (E 1201) in foods for special medical purposes was also considered in this assessment.
EFSA Panel on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Karl‐Heinz Engel, Paul Fowler, Peter Fürst, Rainer Gürtler, Ursula Gundert‐Remy, Trine Husøy, Melania Manco, Wim Mennes, Peter Moldeus, Sabina Passamonti, Romina Shah, Dina Hendrika Waalkens‐Berendsen, Detlef Wölfle, Matthew Wright, Polly Boon, Riccardo Crebelli, Alessandro Di Domenico, Metka Filipič, Alicja Mortensen, Ruud Woutersen, Henk Van Loveren, Alessandra Giarola, Federica Lodi, Ana Maria Rincon, Alexandra Tard, Maria Jose Frutos Fernandez   +29 more
wiley   +1 more source

Formulation and Optimization of Monolithic Fixed‐Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2020, Issue 1, 2020., 2020
The treatment of type II DM involves the use of combination of drugs, especially at the chronic stage. However, the pill burden of this combination therapy combined with swallowing difficulties, occurring at a later stage of DM, has been the major challenge for successful treatment outcomes.
Anteneh Belayneh, Fantahun Molla, Getu Kahsay, Jaleh Varshosaz   +3 more
wiley   +1 more source

Development and In Vitro Evaluation of Buccal Effervescent Tablet Containing Ropinirole Hydrochloride

Polytechnic Journal, 2019
The buccal delivery is an attractive route to improve the clinical efficacy of ropinirole hydrochloride (RH) for the treatment of Parkinson and restless syndrome since this drug undergoes extensive first-pass effect, which has only 50% bioavailability ...
Shahla S. Smail, Naz J. Ibrahim, Nozad R. Hussein   +2 more
doaj   +1 more source

Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To formulate diclofenac sodium as fast dissolving tablets (FDTs) using fenugreek gum as a natural superdisintegrant which also possess anti-inflammatory activity.
M. Uday Kumar, M. Kishore Babu
doaj   +1 more source

Optimising the release rate of naproxen liqui-pellet: a new technology for emerging novel oral dosage form [PDF]

, 2019
Liqui-pellet is a new dosage form stemming from pelletisation technology and concept from liquisolid technology. In spite of liqui- pellet overcoming a major hurdle in liquisolid technology through achieving excellent flow property with high liquid load ...
Ghafourian, Taravat, Lam, Matthew, Nokhodchi, Ali   +2 more
core   +2 more sources