Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure [PDF]
Pharmaceutics, 2022 Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever.
Audrey Yi Zheng +2 more
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Formulation of Ebastine Fast-Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters [PDF]
The Scientific World Journal, 2022 Ebastine is a long-acting, nonsedating, second-generation antihistaminic drug that prevents histamine action, mainly in immediate hypersensitivity.
Bhawana Dhakal +8 more
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Development and Evaluation of an Orodispersible Tablet Formation for the Delivery of a Hydrophobic Drug [PDF]
Advances in Pharmacological and Pharmaceutical SciencesOrodispersible tablet (ODT) is a promising avenue for drug delivery, offering a dosage form that can be disintegrated instantaneously in the mouth and released the drug that dissolves or disperses in the saliva without the addition of water.
Razan Haddad, Ahmed R. Gardouh
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Palatable Levocetirizine Dihydrochloride Solid Dispersed Fast-Dissolving Films: Formulation and In Vitro and In Vivo Characterization [PDF]
The Scientific World Journal, 2022 One of the most important issues for bitter-tasting drugs such as levocetirizine dihydrochloride (LCD) is the production of palatable dosage forms. LCD also has a delayed onset of action following oral administration.
Sana Saleh Al-Kubati +2 more
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Studies on jackfruit seed starch as a novel natural superdisintegrant for the design and evaluation of irbesartan fast dissolving tablets [PDF]
Integrative Medicine Research, 2017 Background: In the present investigation, an attempt was made to isolate starch from jackfruit seed powder and utilize it as a superdisintegrant to design fast dissolving tablets of irbesartan.
Vidyadhara Suryadevara +4 more
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Novel nanocrystal-based solid dispersion with high drug loading, enhanced dissolution, and bioavailability of andrographolide [PDF]
International Journal of Nanomedicine, 2018 Yueqin Ma,1,2,* Yang Yang,2,* Jin Xie,1 Junnan Xu,1 Pengfei Yue,1 Ming Yang1 1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, 2Department of Medicine and ...
Ma Y, Yang Y, Xie J, Xu J, Yue P, Yang M
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Development of Diclofenac Sodium 3D Printed Cylindrical and Tubular-Shaped Tablets through Hot Melt Extrusion and Fused Deposition Modelling Techniques [PDF]
Pharmaceuticals, 2023 The present study aimed to develop 3D printed dosage forms, using custom-made filaments loaded with diclofenac sodium (DS). The printed tablets were developed by implementing a quality by design (QbD) approach.
Tryfon Digkas +9 more
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Superdisintegrant Selection for Tramadol Dispersible Tablets
Revista de Ciências Farmacêuticas Básica e Aplicada, 2010 The selection of a suitable superdisintegrant for a rapidly disintegrating dosage form is of the utmost importance, since disintegration time (DT) is a critical parameter.
Swati C. Jagdale +3 more
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Modeling the Impact of Excipients Selection on Nitrosamine Formation towards Risk Mitigation
Pharmaceutics, 2023 Risk control for nitrosamine impurities in drug products is currently a major challenge in the industry. Nitrosamines can form during drug product manufacturing and storage through the reaction of nitrites with amine-containing APIs or impurities.
Alberto Berardi +2 more
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Superdisintegrants: Brief Review
Journal of Drug Delivery and Therapeutics, 2022 Oral disintegrating tablets are a new trend in novel drug delivery systems that have seen a surge in popularity in recent decades. To improve the efficacy of solid dosage forms, super disintegrants are used. This is accomplished by reducing the disintegration time, which improves the rate of drug dissolution. Disintegrants are substances or combination
D.N. Prasad, Dhruv Dev, Jasmine Dhiman
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