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Superdisintegrants used in pharmaceutical technology
Česká a slovenská farmacie, 2018Disintegrants are substances which promote disintegration of the solid dosage form in the dissolution medium or body fluids. Efficient disintegration is an important prerequisite for ensuring release of the active substance and its good bioavailability.
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Comparative study of natural disintegrants, selection criteria for superdisintegrants
World Journal of Pharmaceutical Sciences, 2022Natural super disintegrants have been used for fast dissolving tablets because they are biodegradable, chemically inert, non-harmful, more affordable and widely available. The natural polymer improves the properties of the tablet as it is commonly used as diluents and binders.
Sonu Kanaujiya, Sunil Kumar
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Water content determination of superdisintegrants by means of ATR-FTIR spectroscopy
Journal of Pharmaceutical and Biomedical Analysis, 2012Water contents of superdisintegrant pharmaceutical excipients were determined by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy using simple linear regression. Water contents of the investigated three common superdisintegrants (crospovidone, croscarmellose sodium, sodium starch glycolate) varied over a wide range (0-24%,
G, Szakonyi, R, Zelkó
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Recent Strategic Developments in the Use of Superdisintegrants for Drug Delivery
Current Pharmaceutical Design, 2020Improving drug bioavailability in the pharmaceutical field is a challenge that has attracted substantial interest worldwide. The controlled release of a drug can be achieved with a variety of strategies and novel materials in the field. In addition to the vast development of innovative materials for improving therapeutic effects and reducing side ...
Phuong H.L. Tran, Thao T.D. Tran
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International Journal of Biological Macromolecules, 2014
Psyllium husk (Plantago ovata, Family: Plantaginaceae) contains a high proportion of hemicellulose, composed of a xylan backbone linked with arabinose, rhamnose, and galacturonic acid units (arabinoxylans). Polysaccharide was isolated from Psyllium husk using solvent precipitation method.
Harshal, Pawar, Chhaya, Varkhade
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Psyllium husk (Plantago ovata, Family: Plantaginaceae) contains a high proportion of hemicellulose, composed of a xylan backbone linked with arabinose, rhamnose, and galacturonic acid units (arabinoxylans). Polysaccharide was isolated from Psyllium husk using solvent precipitation method.
Harshal, Pawar, Chhaya, Varkhade
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A new approach to determining the performance of superdisintegrants
Journal of Bioactive and Compatible Polymers, 2014Superdisintegrants are used in some tablet formulations to improve water penetration and disintegration, leading to improved drug dissolution rates. The extremely fast speeds at which superdisintegrants perform their functions have made it difficult to evaluate differences in their disintegration properties.
Joshi, Yogesh N. +3 more
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Investigation of Dissolution Enhancement of Itraconazole by Solid Dispersion in Superdisintegrants
Drug Development and Industrial Pharmacy, 2000Solid dispersions of itraconazole (ITR) in lactose, microcrystalline cellulose (MCC), and three superdisintegrants (Primogel, Kollidon CL, and Ac-Di-Sol) and their formulation into tablets were investigated with an objective of enhancing the dissolution rate of ITR from tablet formulations. X-ray diffraction (XRD) and differential scanning calorimetry (
K P, Chowdary, S S, Rao
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Drug Development and Industrial Pharmacy, 2007
The objective of this study was to formulate directly compressible rapidly disintegrating tablets of fenoverine with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration.
Sunil Kumar, Battu +3 more
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The objective of this study was to formulate directly compressible rapidly disintegrating tablets of fenoverine with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration.
Sunil Kumar, Battu +3 more
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Superdisintegrant: The Prerequisite for the development of Orodispersible Tablets
Research Journal of Pharmacy and TechnologyDisintegration and then dissolution yield the compositions' medicinal efficacy. The proper disintegrant must be used in tablets and capsules in order to provide the best bioavailability. Disintegrants are the ingredients that break down tablets or capsules quickly into tiny pieces so they dissolve faster than they would if they didn't have them ...
Ranu Biswas +5 more
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DEVELOPMENT AND EVALUATION OF METFORMIN TABLETS: EFFECT OF SUPERDISINTEGRANTS
INDIAN DRUGSMetformin is an oral antihyperglycemic medication used to treat type 2 diabetes. BCS-III classification of medications includes metformin hydrochloride, which has a high solubility and a low permeability. This study’s objective was to develop wet granulated metformin hydrochloride tablets using various synthetic superdisintegrants.
Sankar Veintramuthu +2 more
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