Results 61 to 70 of about 4,805 (183)

Acute intermittent hypoxia in neonatal rodent central nervous system facilitates respiratory frequency through the recruitment of hypothalamic areas

Experimental Physiology, Volume 110, Issue 9, Page 1358-1376, September 1, 2025.
Abstract Moderate and acute intermittent hypoxia (IH) facilitates respiration in adults, mostly by recruiting peripheral chemo‐/baroreceptors. As central chemoreceptors are widely expressed in immature brains, we hypothesized that IH modulates respiration at birth through a purely neurogenic mechanism involving the hypothalamus.
Rosamaria Apicella, Graciela L. Mazzone, Giuliano Taccola   +2 more
wiley   +1 more source

Delving into the significance of the His289Tyr single-nucleotide polymorphism in the glutamate ionotropic receptor kainate-1 (Grik1) gene of a genetically audiogenic seizure model

Frontiers in Molecular Neuroscience
Genetic abnormalities affecting glutamate receptors are central to excitatory overload-driven neuronal mechanisms that culminate in seizures, making them pivotal targets in epilepsy research.
Sandra M. Díaz-Rodríguez, Sandra M. Díaz-Rodríguez, Sandra M. Díaz-Rodríguez, M. Javier Herrero-Turrión, M. Javier Herrero-Turrión, M. Javier Herrero-Turrión, Carlos García-Peral, Carlos García-Peral, Ricardo Gómez-Nieto, Ricardo Gómez-Nieto, Ricardo Gómez-Nieto   +10 more
doaj   +1 more source

Tectal etiology for irrepressible saccades: a case study in a Rhesus monkey [v1; ref status: indexed, http://f1000r.es/we]

F1000Research, 2013
Brain circuits controlling eye movements are widely distributed and complex. The etiology of irrepressible square wave saccades is not fully understood and is likely different for different neuropathologies.
James W Gnadt, Christopher T Noto, Jagmeet S Kanwal   +2 more
doaj   +1 more source

Association of Reduced Brain Metabolism With Motor Function and Survival in Amyotrophic Lateral Sclerosis Patients With Neurofilament Heavy (NEFH) Gene Mutation

European Journal of Neurology, Volume 32, Issue 7, July 2025.
NEFH‐ALS had brain glucose hypometabolism of the cortex‐striatum/limbic system‐brainstem circuit, correlated with motor function, cognition, and depression. Brain glucose hypometabolism could lead to impairment of motor function, which was mediated by cognition and depression.
Xinyu Song, Xueying Wang, Fan Hu, Pan Liu, Ziqin Liu, Jiping Yi, Renxu Xu, Wenfeng Cao, Yuanchao Zhang, Junling Wang, Alessandro Grecucci, Xiaoping Yi, Bihong T. Chen   +12 more
wiley   +1 more source

Tectal etiology for irrepressible saccades: a case study in a Rhesus monkey [v2; ref status: indexed, http://f1000r.es/1bu]

F1000Research, 2013
Brain circuits controlling eye movements are widely distributed and complex. The etiology of irrepressible square wave saccades is not fully understood and is likely different for different neuropathologies.
James W Gnadt, Christopher T Noto, Jagmeet S Kanwal   +2 more
doaj   +1 more source

Neuronal activity modulates the expression of secretagogin, a Ca2+ sensor protein, during mammalian forebrain development

Acta Physiologica, Volume 241, Issue 5, May 2025.
Abstract Aim Because of their stable expression, some EF‐hand Ca2+‐binding proteins are broadly used as histochemical markers of neurons in the nervous system. Secretagogin is a member of “neuron‐specific” Ca2+‐sensor proteins, yet variations in its expression due, chiefly, to neuronal activity remain ambiguous.
János Hanics, Evgenii O. Tretiakov, Roman A. Romanov, Anna Gáspárdy, Zsófia Hevesi, Robert Schnell, Tibor Harkany, Alán Alpár   +7 more
wiley   +1 more source

Editorial: The Jilted Brain: Neglected Structures and Functions

Frontiers in Systems Neuroscience, 2021
Regina A. Mangieri, Kelly A. Allers, Natalie M. Zahr   +2 more
doaj   +1 more source

Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat

Frontiers in Neuroanatomy, 2018
Individuals aged 12–20 years drink 11% of all alcohol consumed in the United States with more than 90% consumed in the form of binge drinking. Early onset alcohol use is a strong predictor of future alcohol dependence.
Qingyu Zhao, Michael Fritz, Adolf Pfefferbaum, Edith V. Sullivan, Kilian M. Pohl, Natalie M. Zahr, Natalie M. Zahr   +6 more
doaj   +1 more source

Central Involvement in Pure Autonomic Failure: Insights from Neuromelanin‐Sensitive Magnetic Resonance Imaging and 18F‐Fluorodopa‐Positron Emission Tomography

Movement Disorders, Volume 40, Issue 4, Page 716-726, April 2025.
Abstract Background Central synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), involve alpha‐synuclein accumulation and dopaminergic cell loss in the substantia nigra (SN) and locus coeruleus (LC).
Paula Trujillo, Kaitlyn R. O'Rourke, Olivia C. Roman, Alexander K. Song, Kilian Hett, Amy Cooper, Bonnie K. Black, Manus J. Donahue, Cyndya A. Shibao, Italo Biaggioni, Daniel O. Claassen   +10 more
wiley   +1 more source

Glaucoma animal models in rabbits: State of the art and perspectives—A review

Animal Models and Experimental Medicine, Volume 8, Issue 3, Page 429-440, March 2025.
Glaucoma, a visual thief, is characterized by elevated intraocular pressure (IOP) and loss of retinal ganglion cells (RGCs). Selecting suitable animals for preclinical models is of great significance in research on the prevention, early screening, and effective treatments of glaucoma.
Rong Hu, Kai Wu, Jian Shi, Juan Yu, Xiao‐lei Yao   +4 more
wiley   +1 more source