Results 61 to 70 of about 43,261 (267)

Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease

Neurobiology of Disease, 2009
The triple transgenic mouse (3xTgAD), harboring human APPSwe, PS1M146V and TauP301L genes, develops age-dependent forebrain intraneuronal Aβ and tau as well as extraneuronal plaques.
Cassia R. Overk, Christy M. Kelley, Elliott J. Mufson   +2 more
doaj   +1 more source

Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice

Nature Communications, 2022
Solié, Contestabile et al. show that the superior colliculus to ventral tegmental area (VTA) pathway encodes orienting behavior toward conspecifics, and modulates VTA dopamine neurons projecting onto dorsolateral striatum perturbing social interaction.
Clément Solié, Alessandro Contestabile, Pedro Espinosa, Stefano Musardo, Sebastiano Bariselli, Chieko Huber, Alan Carleton, Camilla Bellone   +7 more
doaj   +1 more source

Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits. [PDF]

, 2014
BackgroundThere are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect of the visual scene.
Feldheim, David A, Feller, Marla B, Gonzalez, Cristina, Huberman, Andrew D, Sweeney, Neal T, Triplett, Jason W, Wei, Wei   +6 more
core   +2 more sources

Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility

Autism Research, EarlyView.
ABSTRACT Auditory hypersensitivity is a prominent symptom in Fragile X syndrome (FXS), the most prevalent monogenic cause of autism and intellectual disability. FXS arises through the loss of the protein encoded by the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene, FMRP, required for normal neural circuit excitability.
Dorit Möhrle, Demi Ma, Wenyue Xue, Jun Yan, Ning Cheng   +4 more
wiley   +1 more source

Sensorimotor maps can be dynamically calibrated using an adaptive-filter model of the cerebellum.

PLoS Computational Biology, 2019
Substantial experimental evidence suggests the cerebellum is involved in calibrating sensorimotor maps. Consistent with this involvement is the well-known, but little understood, massive cerebellar projection to maps in the superior colliculus.
Emma D Wilson, Sean R Anderson, Paul Dean, John Porrill   +3 more
doaj   +1 more source

Supermultipotency and unpredictability in the developing superior colliculus. [PDF]

Trends Neurosci
A recent study by Cheung, Pauler, Koppensteiner et al. combining lineage tracing with single-cell RNA sequencing (scRNA-seq) has revealed unexpected features of the developing superior colliculus (SC). Extremely multipotent individual progenitors generate all types of SC neurons and glial cells that were found to localize in a non-predetermined pattern,
Rudenko A, Kim IJ.
europepmc   +3 more sources

A Core Head, Neck, and Neuroanatomy Syllabus for Physical Therapy Student Education

Clinical Anatomy, EarlyView.
ABSTRACT Head, neck, and neuroanatomy are essential components of physical therapy education due to their broad clinical applications. Detailed syllabi exist for medical students, yet none have been developed for physical therapy. This study aimed to produce an International Federation of Associations of Anatomists core head, neck, and neuroanatomy ...
Stephanie J. Woodley, Brooke Willoughby, Alexandra L. Webb, Natasha A. M. S. Flack, Laura Y. Whitburn   +4 more
wiley   +1 more source

The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice

Nature Communications, 2021
Goal-oriented movement is a fundamental animal behaviour. Here, the authors show that neurons in the superior colliculus project to the substantia nigra pars compacta, regulating dopaminergic signaling and specifically appetitive locomotion in mice.
Meizhu Huang, Dapeng Li, Xinyu Cheng, Qing Pei, Zhiyong Xie, Huating Gu, Xuerong Zhang, Zijun Chen, Aixue Liu, Yi Wang, Fangmiao Sun, Yulong Li, Jiayi Zhang, Miao He, Yuan Xie, Fan Zhang, Xiangbing Qi, Congping Shang, Peng Cao   +18 more
doaj   +1 more source

Exploration of the functional consequences of fixational eye movements in the absence of a fovea. [PDF]

, 2020
A recent theory posits that ocular drifts of fixational eye movements serve to reformat the visual input of natural images, so that the power of the input image is equalized across a range of spatial frequencies.
Agaoglu, Mehmet N, Chung, Susana TL
core  

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source