Results 61 to 70 of about 23,784 (226)

Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease

Neurobiology of Disease, 2009
The triple transgenic mouse (3xTgAD), harboring human APPSwe, PS1M146V and TauP301L genes, develops age-dependent forebrain intraneuronal Aβ and tau as well as extraneuronal plaques.
Cassia R. Overk, Christy M. Kelley, Elliott J. Mufson   +2 more
doaj   +1 more source

Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice

Nature Communications, 2022
Solié, Contestabile et al. show that the superior colliculus to ventral tegmental area (VTA) pathway encodes orienting behavior toward conspecifics, and modulates VTA dopamine neurons projecting onto dorsolateral striatum perturbing social interaction.
Clément Solié, Alessandro Contestabile, Pedro Espinosa, Stefano Musardo, Sebastiano Bariselli, Chieko Huber, Alan Carleton, Camilla Bellone   +7 more
doaj   +1 more source

Cortical and subcortical somatosensory regulation of dopaminergic neurons: role of the superior colliculus [PDF]

, 2011
Dopaminergic (DA) neurons exhibit a short-latency, phasic response to unexpected biologically salient stimuli, including rewards. Despite extensive research on this DA signal, very little is known about the sources of sensory ...
Bertram, Craig
core  

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Detecting biological motion signals in human and monkey superior colliculus: a subcortical-cortical pathway for biological motion perception

Nature Communications
Most vertebrates, including humans, are highly adept at detecting and encoding biological motion, even when it is portrayed by just a few point lights attached to the head and major joints.
Xiqian Lu, Zhaoqi Hu, Yumeng Xin, Tianshu Yang, Ying Wang, Peng Zhang, Ning Liu, Yi Jiang   +7 more
doaj   +1 more source

Sensorimotor maps can be dynamically calibrated using an adaptive-filter model of the cerebellum.

PLoS Computational Biology, 2019
Substantial experimental evidence suggests the cerebellum is involved in calibrating sensorimotor maps. Consistent with this involvement is the well-known, but little understood, massive cerebellar projection to maps in the superior colliculus.
Emma D Wilson, Sean R Anderson, Paul Dean, John Porrill   +3 more
doaj   +1 more source

Adaptation of Binaural Processing in the Adult Brainstem Induced by Ambient Noise [PDF]

, 2012
Interaural differences in stimulus intensity and timing are major cues for sound localization. In mammals, these cues are first processed in the lateral and medial superior olive by interaction of excitatory and inhibitory synaptic inputs from ipsi- and ...
Siveke, Ida, Grothe, Benedikt, Leibold, Christian, Schiller, Evelyn   +3 more
core   +1 more source

Navicular and fifth metatarsal base stress fractures: An illustrated anatomical review

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract The navicular bone and the proximal fifth metatarsal (M5) play a vital role in maintaining the structural integrity and biomechanical stability of the foot's medial and lateral columns, respectively. Both bones' unique anatomical configuration, intricate mechanical environment and limited vascular supply make specific locations particularly ...
Xiuqi Liu, Choon Chiet Hong, Francisco Reina, Anna Carrera, Enric Alcolea‐Madera, Jorge Javier Del Vecchio, Miki Dalmau‐Pastor   +6 more
wiley   +1 more source

A Role for the Superior Colliculus in Decision Criteria [PDF]

SSRN Electronic Journal, 2018
Simple decisions arise from the evaluation of sensory evidence. But decisions are determined by more than just evidence. Individuals establish internal decision criteria that influence how they respond. Where or how decision criteria are established in the brain remains poorly understood. Here, we show that neuronal activity in the superior colliculus (
Trinity B, Crapse, Hakwan, Lau, Michele A, Basso   +2 more
openaire   +2 more sources

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source