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Engineered Superoxide Dismutase Monomers for Superoxide Biosensor Applications
Analytical Chemistry, 2005Because of its high reaction rate and specificity, the enzyme superoxide dismutase (SOD) offers great potential for the sensitive quantification of superoxide radicals in electrochemical biosensors. In this work, monomeric mutants of human Cu,Zn-SOD were engineered to contain one or two additional cysteine residues, which could be used to bind the ...
Beissenhirtz, Moritz Karl +3 more
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Parasitology Today, 1994
Eric James here discusses the molecular forms of superoxide dismutase and looks at its potential role in the pathogenesis of parasitic infections.
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Eric James here discusses the molecular forms of superoxide dismutase and looks at its potential role in the pathogenesis of parasitic infections.
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Extracellular superoxide dismutase
The International Journal of Biochemistry & Cell Biology, 2005The extracellular space is protected from oxidant stress by the antioxidant enzyme extracellular superoxide dismutase (EC-SOD), which is highly expressed in selected tissues including blood vessels, heart, lungs, kidney and placenta. EC-SOD contains a unique heparin-binding domain at its carboxy-terminus that establishes localization to the ...
Eva, Nozik-Grayck +2 more
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Keratinocyte Superoxide Generation
Free Radical Biology and Medicine, 1998We have demonstrated using the reduction of cytochrome c, that the keratinocyte cell line H357 generates superoxide at significant rates (8.36 nmol/h/10[6] cells). The rate of superoxide release decreased as the cells reached confluence. Superoxide production was increased more than twofold following preincubation with IL-1beta, or by the addition of ...
Turner, CP, Toye, AM, Jones, OTG
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The Journal of Physical Chemistry B, 2005
Density-functional calculations indicate that the second sphere of coordination around the metal centers of manganese and iron superoxide dismutases (MnSODs and FeSODs) plays an important role in the binding of O2(-). In these systems, O2(-) prefers to bind to Mn or Fe in end-on configurations. For human and E.
Isabel A, Abreu +2 more
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Density-functional calculations indicate that the second sphere of coordination around the metal centers of manganese and iron superoxide dismutases (MnSODs and FeSODs) plays an important role in the binding of O2(-). In these systems, O2(-) prefers to bind to Mn or Fe in end-on configurations. For human and E.
Isabel A, Abreu +2 more
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Superoxide, superoxide dismutase and ischemic injury.
Current opinion in investigational drugs (London, England : 2000), 2002Oxidative stress results from an oxidant/antioxidant imbalance: an excess of oxidants relative to the antioxidant capacity. Recent evidence strongly suggests that oxidant stress plays a major role in several aspects of ischemia and reperfusion. Immunohistochemical and biochemical evidence demonstrate the significant role of reactive oxygen species, in ...
Salvemini, Daniela, CUZZOCREA, Salvatore
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Superoxidation of Retinoic Acid
Photochemistry and Photobiology, 2006Atmospheric pressure chemical ionization mass spectroscopy (APCI-MS) was used to examine the light-induced oxidation products of retinoic acid under conditions that favor and preclude its aggregation. We observed that in conditions that favor aggregation, i.e. in aqueous solutions, retinoic acid undergoes superoxidation to yield highly oxidized species.
Ilyas, Washington +2 more
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Superoxide Dismutases: Defence Against Endogenous Superoxide Radical
2008Attempts to measure the rate of O2- production, in whole cells or in intact subcellular organelles, are frustrated by the endogenous superoxide dismutase (SOD). Streptococcus faecalis contains a single manganese-SOD which was isolated and used as an antigen in the rabbit. A precipitating and inhibiting antibody was obtained and used to suppress the SOD
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Superoxide Dismutase Biosensors for Superoxide Radical Analysis
Analytical Letters, 1999ABSTRACT Some basic work has been performed on the development and optimisation of superoxide dismutase (SOD) biosensors for superoxide radical analysis. Initially we studied the possibility of obtaining a SOD biosensor using the Clark electrode as indicating sensor.
CAMPANELLA, Luigi +2 more
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A superoxide dismutase-modified electrode that detects superoxide ion
Chemical Communications, 2002A superoxide dismutase (SOD)-modified electrode, in which SOD is oriented on the gold electrode via a self-assembled monolayer of cysteine so as to allow its direct electrode reaction, possesses a bi-directional electrocatalysis for both the oxidation of superoxide ion (O2-) to O2 and the reduction of O2- to H2O2 and functions as a third generation O2-
T.Ohsaka +4 more
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