Results 61 to 70 of about 145 (85)
Supersulfides to Regulate Electrophilic Stress
Yakugaku ZasshiEnvironmental electrophiles modify thiol groups of proteins in organs, disrupting cellular functions carried out by the modified proteins and increasing the risk of various diseases. The transcription factor NF-E2-related factor 2 (Nrf2) plays a crucial role in detoxifying electrophiles by forming glutathione adducts and subsequently excreting them ...
Yun-Gi Kim, Yoshito Kumagai
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Regulation of innate immune and inflammatory responses by supersulfides
International ImmunologyAbstractInnate immunity plays an important role in host defense against microbial infections. It also participates in activation of acquired immunity through cytokine production and antigen presentation. Pattern recognition receptors such as Toll-like receptors and nucleotide oligomerization domain-like receptors sense invading pathogens and associated
Takaaki Akaike +2 more
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New aspects of redox signaling mediated by supersulfides in health and disease
Free Radical Biology and MedicineOxygen molecules accept electrons from the respiratory chain in the mitochondria and are responsible for energy production in aerobic organisms. The reactive oxygen species formed via these oxygen reduction processes undergo complicated electron transfer reactions with other biological substances, which leads to alterations in their physiological ...
Seiryo Ogata +2 more
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Quantitative profiling of supersulfides naturally occurring in dietary meats and beans
Analytical BiochemistrySulfur is essential in the inception of life and crucial for maintaining human health. This mineral is primarily supplied through the intake of proteins and is used for synthesizing various sulfur-containing biomolecules. Recent research has highlighted the biological significance of endogenous supersulfides, which include reactive persulfide species ...
Takaaki Akaike, Hideshi Ihara
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Redox Regulation of Xenobiotics by Reactive Sulfur and Supersulfide Species
Antioxidants and Redox SignalingSignificance: Routine exposure to xenobiotics is unavoidable during our lifetimes. Certain xenobiotics are hazardous to human health, and are metabolized in the body to render them less toxic. During this process, several detoxification enzymes cooperatively metabolize xenobiotics.
Takaaki Akaike +2 more
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Supersulfides support bone growth by promoting chondrocyte proliferation in the growth plates
Journal of Oral BiosciencesWhile chondrocytes have mitochondria, they receive little O2 from the bloodstream. Sulfur respiration, an essential energy production system in mitochondria, uses supersulfides instead of O2. Supersulfides are inorganic and organic sulfides with catenated sulfur atoms and are primarily produced by cysteinyl tRNA synthetase-2 (CARS2).
Kazuyoshi Baba +2 more
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